A drug called Colchicine for hypo symptoms

[Koola]

A general practitioner told me that a drug called Colchicine, which is used to treat gout, is helpful for people suffering from hypo symptoms, like painful joints, legs etc.

Any opinions?

[greygoose]

If symptoms are caused by lack of a certain hormone, then you need to replace that hormone to get relief. You can only replace a hormone with a hormone, not a drug, or anything else. But, doctors would far rather prescribe drugs than hormones.

Same with nutrients. Painful joints are often caused by low nutrient levels, but they don't want to test the nutrients nor treat deficiencies, because that doesn't bring in any money for Big Pharma.

Beware of doctors peddling drugs! They may not stand on street corners, but they're just as dangerous.

[Koola in reply to greygoose]

Thanks for your answer.

He didn't say I should replace hormones but that Colchicine would help with pain. It seemed strange to me that a drug for gout would help with thyroid problems.... yet I posted this on an off chance that it might have helped someone somewhere.

Afterwards, he said that if it didn't help I should take iodine drops. I often read that iodine worsened hypothyroidism, So I just asked if he was sure. Now I think you better sit down before I tell you his answer: oh yes, and you could stop all hormones and just take iodine, there's a new formula and it will do it....

I didn't bother to answer that one. that was replacingT

He's not even pushing drugs, he's just ignorant but won't, can't admit it. He came to the iodine bit because I told him that the only times I feel without pain is when I'm swimming in the sea. But that's due to being weightless in the water and therefore no strain on muscles, i.e. I not only can swim but jump up and down 20 or 30 times, whereas on land 3 times is max.

I shudder to think about his other patients and how he advises them. and he's got such a great reputation on this island!

[greygoose in reply to Koola]

Well, I just googled it and it's a plant extract that is anti-inflammatory, so yes, it would help with pain. But just mask it, not cure the root cause.

But, as to his views on iodine, this man is dangerous! But, he's not alone. There are other doctors that think that way, god help us. I always ask: what exactly do you think the iodine is going to do? And I either don't get an answer, or they say: make the thyroid work better. But they have no idea how it's supposed to do that. Well, as I always say, doesn't matter how many eggs you add to the batter, if the oven is on the blink, you ain't gonna get a cake!

[helvella Administrator Thyroid UK]

Not an opinion!

But a hint of something possibly interesting.

Thyroid Hormone-Dependent Regulation of Galanin Synthesis in Neurons and Glial Cells after Colchicine Administration

Subject Area: Endocrinology , Neurology and Neuroscience

Laura Calzà; Luciana Giardino; Tomas Hökfelt

Neuroendocrinology (1998) 68 (6): 428–436.

doi.org/10.1159/000054393

Abstract

Galanin and galanin message-associated peptide (GMAP) synthesis is up-regulated in neurons and glial cells in the adult rat brain by different experimental manipulations, including intracerebroventricular colchicine. We have previously reported that the galanin expression is severely attenuated in some neurons in adult hypothyroidism. In order to further investigate the role of thyroid hormone for the in vivo regulation of galanin gene expression, we have studied the effect of intraventricular administration of colchicine on prepro-galanin (ppGAL) mRNA expression in the brain of normal and hypothyroid, adult male rats. While ppGAL mRNA levels were markedly elevated in a great number of glial cells in the white and gray matter in normal rats, this effect was almost completely abolished in hypothyroid rats. In contrast, colchicine-induced up-regulation of galanin/GMAP expression occurs in the hypothalamic paraventricular nucleus both of euthyroid and hypothyroid rats, although with a slightly different time course.

journals.sagepub.com/doi/10...

One the right side of that link, there area few citations which I have not followed through.

[Koola in reply to helvella]

Thanks for info, Helvella, but this is way above my concentration faculties at the moment... or maybe at any given moment?

I did read that gout can affect thyroid and bring about hypothyroidism, but since I got it already, stopped enquiring.

[Sparklingsunshine]

Colchicine is an anti inflammatory which is used mainly for gout but can be used for other inflammatory conditions. I was prescribed it by the cardiologist I saw in July as I had a bout of Pericarditis. Inflammation of the fluid around the heart.

I was also prescribed Prednisolone steroids which did the trick so I never took the Colchicine It can really affect your stomach lining and cause GERD so they often have to prescribe PPI drugs like Omeprazole for you to take alongside it. And PPI's can adversely affect your ability to absorb B vitamins, notably B12.

I can see Colchicine helping with conditions like arthritis, especially rheumatoid, as it damps down inflammation but I'm struggling to see it helping with thyroid related aches and pains as they are caused by low levels of thyroid hormones, not inflammation. I would be wary of taking it personally.

[Brightness14]

It's likely low FT3 nothing else I have the same when my FT3 is too low. GP's peddling drugs forget it.

[Blissful]

Have been on T3/T4 Combo since Spring 2021. No improvement at all, feeling steadily worse.

That's from your bio - have you still had no improvement? I hope you were properly diagnosed for Graves? Do you also have Hashimotos? I'm sure RAI causes havoc for the body.

he's got such a great reputation on this island!

I live on a Greek island too - could you send me a message with this doctor's name/location - due to Uni-pharma not supplying T3 any more, my local pharmacy advised I see an Endo who, having determined a need for T3 will then be able to "find it" for you. (perhaps using the "brown envelope" system - (I would like to avoid your chap!).

My own feeling is that living near the sea means we actually get a decent amount of iodine (in the air)

readersdigest.ca/health/bea...

apart from the obvious benefit of feeling weightless when swimming, maybe you are short on magnesium and that has major impact on everything.

[Kriticat in reply to Blissful]

I'm on Crete and have been told by a doctor and an endocrinologist that Greece has so many people with thyroid problems because of excess iodine in the soil as a result of the fallout from chernobyl. I haven't had my iodine tested, but if that's true, taking extra iodine could be dangerous.

[Blissful in reply to Kriticat]

I think that's very plausible - that event caused no end of issues in north eastern Greece as well (due to proximity).

I live on Crete as well - I'm not sure there's a credible iodine test here. I'm not a big fan of testing everything anyway!

The doc who said to Koola "oh yes, and you could stop all hormones and just take iodine, there's a new formula and it will do it...." is clearly a dangerous idiot.

[Kriticat in reply to Blissful]

I was surprised, as the lake district had a big problem too, in the opposite direction! But i gueas there was falllout for days! I am all for testing, as I was initially prescribed selenium, which I'm high in, and actually needed zinc! But you are right, I have asked for iodine test, and the lab called round various places but couldn't do it.... which seems strange if we might all have excess! But yes, there are a huge number of dangerous idiots posing as health professionals!

[Blissful in reply to Kriticat]

I was surprised, as the lake district had a big problem too

The wind changed direction - the Welsh sheep farmers were badly affected and going back to the late 1950's Sellarfield/ Windscale in Cumbria had been experiencing a fire and small leaks.

Just to say since you are the locale, in mid May there was fallout from a US weapon that went off in Ukraine - there have been negative agricultural consequences (e.g. virtually total grape harvest failure)!

[Kriticat in reply to Blissful]

Wow, I didn't know that, I thought it was the late spring... it was cold here in the south until mid June and our grapes have failed. In fact almost everything has this year, so could be related!

[Blissful in reply to Kriticat]

I'm sure it's related - I've successfully been growing my food organically for 30 years but like you, virtually everything has failed! (I'm mid north).

[Koola]

Hi Blissful

will send message soon, as soon as a little bit more energy appears on the horizon... usually evenings,

which island are you on?

[Blissful in reply to Koola]

Thank you. I'm on Crete.

[Koola in reply to Blissful]

The doc I mentioned isn't an endo.

Don't know how long you've been living in Greece, so maybe you 've already found out what a friend told me many years ago: "here, everything is negotiable" .

If your a doctor's "client: i.e. patient, they'll have no objection to prescribing whatever you need or think you need. (Unless it's a drug with 2 red stipes on it, like morphine, but even that can be had...)

[Blissful in reply to Koola]

Thank you Koola.

+3 decades here - all "systems" are inherently open to corruption - they've been "designed" that way.

[arTistapple]

Just thinking. Really, being a doctor is only one step up from a Mother cleaning and putting a plaster on a child’s cut, only the Mother is supplying genuine care, knowledge and attention as well. A much better arrangement than paying huge amounts of money to a person who just remembers facts and no idea under what circumstances etc in which to apply them. I wonder if they ever wonder what on Earth they are doing? No sign as far as I can see.

[Blissful in reply to arTistapple]

I wonder if they ever wonder what on Earth they are doing?

I'm sure some do and then they get out of the "profession" because they realise their brainwashing has been involved with HARMING people rather than helping people HEAL.

[arTistapple in reply to Blissful]

Oh dear these are the ones we should probably be keeping in the profession.