Abaris

[Sooty101]

Hello everyone, I'm still on the quest for wellness. I was wondering if anyone had tried Abaris which is a TRH . Quite new on the market I think. I'm piling the weight on as I can't treat my thyroid without reacting to the meds. I was looking further upstream at TRH. I live in the UK so probably wouldn't be able to get hold of any...and I'd probably react to it anyway., but was wondering if anyone had tried it?

[jimh111]

As far as I know you can't get it in the UK. Many people have a TSH that stays lower than expected so perhaps a few weeks on TRH might kick the pituitary back into life.

[Sooty101 in reply to jimh111]

Thanks Jimh for your reply. Do you think you could explain a little more what you mean. I was hoping to take TRH in order to stimulate the pituitary gland. Sorry feeling a bit foggy today

[Alanna012 in reply to jimh111]

Are you suggesting that only an initial dose until one sees some stimulatory effect might be all that is necessary, and one wouldn't necessarily have to keep taking it on a regular basis? The pituitary will 'wake up' and take over somehow?

That would be good as I note it only has 30 pills per bottle!!

Thanks for drawing attention to this product Sooty101

[Sooty101 in reply to Alanna012]

Hi Alanna, I've no idea how it works but that would be great wouldn't it!!

[Alanna012 in reply to Sooty101]

It certainly would!

[Lalatoot]

drugs.com/pro/thyrotropin-r...

This article explains more. I haven't read it all so hope it is helpful.

[Sooty101 in reply to Lalatoot]

Yes this is IV injection via prescription, thanks for the link. Abaris is, I believe the first TRH to be available to the public (if you live in the right country). It's a start and it will be interesting to see how things go.

[jimh111]

Unfortunately the studies I've seen some time ago are old and diffiicult to follow. They do show that as expected TRH increases TSH along with T3 and T4, The increase in TSH declines with repeated TRH doses and it is not clear if this is just due to higher fT3, fT4 levels or the TSH response to TRH becomes blunted.

What we can be more sure of is that if TSH is suppressed for a long time by e.g. Graves' or high doses of LT3 or LT4 the 'axis' becomes down-regulated - TSH remains lower than it should be for give fT3, fT4. The axis takes something like 3 to 18 months to recover for most but not all people. This is a problem because most of us cannot be off thyroid hormone for that length of time. The other issue is the studies are poor, they define recovery of the axis as TSH, fT3 or fT4 returning to their reference intervals not back to the sort of level they would have been before.

Another consideration is that the degree of TRH stimulation determines the bioactivity of TSH, not all TSH are equal! TSH is a group of isoforms with varying bioactivity. TST also seems to stimulate T4 to T3 conversion.

My thoughts are a little TRH might allow a reduced hormone intake giving time for the axis to recover, allowing patients to survive on lower overall hormone doses because local T4 to T3 conversion has been stimulated.

We really don't know if TRH therapy would be successful. My view is that a down-regulated axis is the most common cause of severe hypothyroidism in patients who have TSH, fT3, fT4 levels seemingly normal (but all low normal). I think this is the most important aspect of hypothyroidism that needs to be studied now.

[Sooty101]

Thank you Jimh, all interesting stuff. I'm waiting for the axis to mend after benzo withdrawal, but It's hard not to keep looking for that something to help things along. .