Crosstalk between the neuroendocrine system and bone homeostasis

[helvella]

Immensely frustrating that the abstract is so sparse and that is all we can access.

At present, I simply hope we can get away from the extremely simplistic view that low TSH, in itself, causes bone problems. But all we can really see is that it is complicated.

Crosstalk between the neuroendocrine system and bone homeostasis

Yuhu Zhao, Xiaole Peng, Qing Wang, Zhiyu Zhang, Liangliang Wang, Yaozeng Xu, Huilin Yang, Jiaxiang Bai, Dechun Geng

Endocrine Reviews, bnad025, doi.org/10.1210/endrev/bnad025

Published: 17 July 2023

Abstract

The homeostasis of bone microenvironment is the foundation of bone health and comprises two concerted events: bone formation by osteoblasts and bone resorption by osteoclasts. In the early 21st century, leptin, an adipocytes-derived hormone was found to affect bone homeostasis through hypothalamic relay and sympathetic nervous system, involving neurotransmitters like serotonin and norepinephrine. This discovery has provided a new perspective regarding the synergistic effects of endocrine and nervous systems on skeletal homeostasis. Since then, more studies were conducted, gradually uncovering the complex neuroendocrine regulation underlying bone homeostasis. Intriguingly, bone is also considered as an endocrine organ that can produce regulatory factors which in turn exert effects on neuroendocrine activities. After decades of exploration into bone regulation mechanisms, separate bioactive factors have been extensively investigated, whereas few studies have systematically shown a global view of bone homeostasis regulation. Therefore, we summarized the previously studied regulatory patterns from nervous system and endocrine system to bone. This review will provide readers with a panoramic view of the intimate relationship between the neuroendocrine system and bone, compensating for current understanding of the regulation patterns of bone homeostasis, and probably developing new therapeutic strategies for its related disorders.

Abstract only available:

academic.oup.com/edrv/advan...

[wellness1]

Along the same lines, How Bones Communicate With the Rest of the Body.

smithsonianmag.com/science-...

[helvella in reply to wellness1]

Very similar in many ways.

Neither makes any mention of thyroid hormones, nor TSH, in what I can see. Which probably means both that TSH isn't the sole factor that so many medics seem to think/claim. And that the papers have rather missed or avoided thyroid hormone/TSH issues.

[wellness1 in reply to helvella]

"...bone is also considered as an endocrine organ..."

I agree, no mention of thyroid hormones seems a glaring omission. When I read articles such as these, I'm excited about future possibilities. Scientists seem on the cusp of important discoveries that will take medicine beyond reductive thinking about TSH, as one example. On the other hand, medicine, as it is often practiced now, carves up the body into specialties/body parts. More systemic thinking will be necessary to understand these complex relationships and overcome that mindset.

[helvella in reply to wellness1]

It was only a modest number of years ago that our skin was recognised as being an endocrine organ.

[Tythrop]

"On the other hand, medicine, as it is often practiced now, carves up the body into specialties/body parts. "This observation is so wise . Everything is connected isn't it .

Ref tsh : I have this thing called "disesse related tsh downregulation" aka Hysteresis of HPT axis ( diagnosed on this site by Diogenese) . So my tsh is permanently supressed to eke out supply of t4 as Thyroid gland adversely effected by anti- tpo antibodies .This TSH downregulation-thing makes me interested in the link,if any, between tsh and bones.Specifically :does the downreg of tsh adversely impact on my bones ? (By coincidence , I have a family history of thyroid probs AND osteoarthritis..so is there a link? )

Or is it the old chestnut that it's really not tsh but T4 and ir T3 that is the effective link ,and the blinkered medical profession can't see beyond tsh .

So I'm wondering if you happen to know from your enlightened position, what tsh does other than turn up or down thyroid's production of t4/3. ?

[helvella in reply to Tythrop]

I've seen various claims over the years but never a good and well-researched explanation.

I often look at the inverse situation.

The amount of TSH that needs to be released to get a blood TSH of 5, 10 or higher is MASSIVELY greater than the amount needed to reach, say, the typical "healthy" point of around 1.

And that is considerably greater than the amount needed to get a blood TSH of, say, 0.3 (possible lower end of reference interval) and which is usually accepted even if it takes a bit of discussion. Which is a bit more than required to get a "just detectable" blood TSH of 0.01 or -.001 (or whatever).

Yet we are asked to believe that living indefinitely with a TSH of up to 10 has so little effect that it warrants only occasional re-tests, if you are lucky. Whereas the difference between 0.3 and 0.01 causes your bones to disappear in five minutes.

That is, if TSH has ANY effects of its own, other than within the thyroid axis, why totally ignore huge amounts? By totally, I do mean very close to literally that. I it is extremely difficult to find it mentioned even in research papers and never in clinical documents.

[Tythrop in reply to helvella]

This is so interesting...its strange that the idea of tsh has such "power" in the medical world and yet there is so little evidence to back.it up....there must be PHD. in there somewhere