This study shows that anxiety and depression scores are higher in people homozygous for DIO2 polymorphism when on T4, (but not if they are not given T4) and quality of life is poorer.
Another study showing effect of DIO2 polymorphi... - Thyroid UK
Another study showing effect of DIO2 polymorphism when on T4
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Mollyfan
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Thank you!
You have most likely also seen this study, but adding for anyone who hasn't....
academic.oup.com/jcem/artic...
Common Variation in the DIO2 Gene Predicts Baseline Psychological Well-Being and Response to Combination Thyroxine Plus Triiodothyronine Therapy in Hypothyroid Patients
Vijay Panicker, Ponnusamy Saravanan, Bijay Vaidya, Jonathan Evans, Andrew T. Hattersley, Timothy M. Frayling, Colin M. Dayan
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