T3 Liothyronin timing

[Wired123]

Hi all

My Endo asked me to increase my T3 from 2 x 5mcg per day (on waking and an hour after lunch) to 3 x 5mcg.

Doctor suggested dose was 10mcg at waking and 5mcg after lunch. The alternative was 5mcg each at those times and then final 5mcg just before getting into bed at night.

I chose the latter option of 3 equal doses and have to say taking T3 at night does not in any way impact my sleep, perhaps even putting me in a slightly deeper sleep.

However I do feel I struggle a bit to wake in the morning and am not “ready to go”, sometimes wake up, use the loo and then go back to lie down again with no intention of getting to my desk to work - luckily I’m wfh at the mo!

Is it worth now trying out the doctor’s other recommendation of 10mcg in the morning and then 5mcg after lunch?

I miss the full of energy jumping out of bed feeling I got in the morning during my first 6 months on T3.

[DippyDame]

It's trial and error!

There are no "rules".

We are all different, it depends on what works best for you...

Find what works for you and stick with that.

I need high dose T3-only to function and take my full dose at bedtime...that works for me, but it probably won't for others.

[Wired123 in reply to DippyDame]

Thanks. I just wanted to get a few opinions/experiences before I make the switch. I agree it’s trial and error, we are all different. Have a pretty busy week next week at work so will hold off making changes that could cause me problems. So perhaps next Saturday will be the day i trial the other dosing schedule.

Keen to hear everyone’s thoughts.

[fuchsia-pink in reply to Wired123]

Absolutely agree with DippyDame - do what works for you. I take my 20 mcg all in the morning, with my levo, because it's easy and I'd otherwise forget to do it consistently (but tell the endo that it's 2 split doses cos that's what he want to hear). Try different things and see what is best for you x

[Wired123 in reply to fuchsia-pink]

All in one go would be ideal with my Levo.

However there are some on here who say taking Levo throughout the day is better for them.

[shaws Administrator in reply to Wired123]

Whatever we decide to do it is for a whole lifetime due to our body not able to produce the thyroid hormones for some reason or another.

There are two important thyroid hormones: named levothyroxine (T4) and inactive - has to convert to (liothyronine) T3 - active thyroid hormone

or

liothyronine (T3) that goes directly into all of our T3 receptor cells and heart and brain contain the most without which our body/brain cannot function.

Thereafter it sends out 'waves; throughout the day.

tpauk.com/main/article/the-...

25mcg of T4 (levothyroxine) is equal to 100mcg of T3 (liothyronine)

[DippyDame in reply to fuchsia-pink]

It beggars belief that in the 21st century we are reduced to telling medics what they want to hear.I was reduced to buying T3 and self medicating because they couldn't/ wouldn't consider prescribing T3, but insisted that I use Levo, which after 20 years had reduced me to a wreck.

High dose T3 changed that.

Turns out I have a form of thyroid hormone resistance.

Without support here I would never have discovered this, and would probably be dead now!!

[shaws Administrator]

The two main thyroid hormones:-

i.e. liothyronine and levothyroxine

liothyronine is the 'active thyroid hormone' (T3) and levothyroxine (T4) the 'inactive hormone' that has to convert to T3.

25mcg of liothyroxine (i.e. T3) is the active thyroid hormone and is needed in our millions of T3 receptor cells from head to toe and brain and heart have the most.

25mcg of levothyroxine is approx 100mcg.levothyroxine (T4) is an inactive hormone and is supposed to convert to T3.The brain and heart contain the most T3 receptor cells.

google.com/search?client=fi...