MCAS , thyroid and menopause

[Swinkie]

Does anyone else have MCAS issues exasebated by the Menopause?

Any tips re hormones, specialists etc?

[bookish]

HI, I would think that anyone with MCAS would have worsened symptoms due to hormonal changes as mast cell release is so strongly oestrogen linked. There seem to be quite a few connections between the thyroid and mast cells (and also between Small Fibre Neuropathy/fibromyalgia, Sjogren's and Dysautonomia - nerve cells and mast cells can trigger each other, hence pain and weird sensations). When oestrogen is higher there are multiple effects in the body. My very basic understanding is that neurotransmitters in nerves and blood vessels need to be in balance - particularly noradrenaline and histamine - and these are strongly influenced by thyroid hormones (T3 and T1AM). Many people notice mast cell degranulation/high histamine issues shortly before a period (flushing, itching, food reactions, blood pressure changes etc.). Variations in the COMT gene have also been linked to fibro. COMT enzyme function (responsible for dopamine, adrenaline and oestrogen metabolism) can be supported by magnesium which will help the liver to clear oestrogen. (And COMT impacts on MTHFR which you also need to be functioning to get a happy liver and detox ability). I have a histamine issue (as yet undiagnosed) along with the above and am using magnesium oil spray or flakes in a footbath/bath plus quercetin along with being careful about histamine raising foods etc, but I'm sure you are doing all that. Hopefully you are not using HRT.

Have a look at healinghistamine.com/allerg... and purehealthclinic.co.uk/?s=MCAS. Best wishes

[bookish]

Hi again, sorry, forgot to ask how you were diagnosed - who by and tests etc. Thank you. You might get more replies if you lock your post - many people don't like to reply to public ones (I don't, usually). Cheers

[Swinkie in reply to bookish]

Thank you for your interesting reply.

I'm doing all the MCAS, low histamine diet, supliments, the medications etc and having adrenals and T3 re checked.

I was diagnosed by my local hospital gastroenterology consultant, but they refuse to do the Triptase test when I'm anaphylactic in A&E which I need to get referred to a Specialist unit, even with a letter and notes on my medical records from their resident gastro.

I've heard that Professor Suranjith Seneviratne

Consultant in Clinical Immunology and Allergy at the Royal Free Hospital and University College London sees private patients for diagnosis of MCAS

I know some people see Tina Peers re hormones and wondered if anyone on here had seen her.

How to I lock my post please?

Once again, thank you for taking your time to reply.

[bookish in reply to Swinkie]

My pleasure, just sorry that I can't help more. I'm afraid I have no knowledge of either of those specialists. I do hope you can get some more support.

Re. locking posts - at the bottom of a new post you should see two options, one of which is 'Only Community Members'. It is better to hit that when you make a post, and people will know because a little padlock appears next to the number of replies at the top of the post. If you have a look at the Posting Guidelines in the Pinned Posts section on the right hand side of any message, there is more about it there.

Best wishes to you x