cytokine storm

[Billyboy2u]

Coronavirus doctors and experts are now finding that patients are now suffering problems with other organs as well as the lungs

However it all caused by cytokine storm now when I was submitted to hospital some 2 years ago with readings way off the charts. I was told I was having a storm too.

Is there some kind of connection here and maybe the treatment could be the same ?

I was put on 20 mg Carbimazole and 200 mg Levothyroxine and in around 8 days I felt much better as it stopped my cytokine storm !!!

ie are those on Levo and Carbimazole treatment who catch Coronavirus survivors surviving more than normal ?

[greygoose]

I was put on 20 mg Carbimazole and 200 mg Levothyroxine and in around 8 days I felt much better as it stopped my cytokine storm !!!

Not quite sure that's how it works. What you're describing is known as 'block and replace'. The Carbi stops the thyroid from working, and the levo replaces the thyroid hormone. I'm not sure either of them have any effect on cytokines. Are you sure they said at the hospital that you had a 'cytokine storm'? It's usually called a 'thyroid storm'.

I don't think there's any connection between hyperthyroidism and Corona virus. And, I really don't think that carbi and levo would cure Corona virus. But, if I'm wrong, I'd be very interested to learn more. Anybody?

[Hidden in reply to greygoose]

Well, there's a connection between hyperthyroidism and viral infections, definitely. I've been doing some digging to try to figure out if we are more at risk from Coronavirus than healthy folk. Certainly the immune system and thyroid hormones are intimately connected.

sciencedirect.com/science/a...

I got access to the full paper via Sci-Hub, which also states:

Previous reports indicate that alterations in TH levels can affect the immune system[34]. Patients with hyperthyroidism frequently manifest unbalanced immuneresponses, including abnormal antibody production (either increased or decreased)[35], increased migration of polymorphonuclear leukocytes [36], lymphocyte proliferation[ 37] and increased reactive oxygen species (ROS ) production by macrophages, specifically hydrogen peroxide and superoxide [38,39]. Additionally, these patients may show reduced levels of pro- inflammatory markers and lower antioxidant enzyme activity. Incontrast, patients with hypothyroidism display an opposite phenotype [40,41]. However, in some cases, contrasting results have been reported and therefore it is difficult to establish a clear correlation between immune function and hyper- or hypo thyroid conditions [35,42,43]. Patients with hypothyroidism show immune deficits and significantly increase susceptibility to infections [44-47]. For example, Ho etal. reported that patients with severe sepsis, septic shock and hemorrhagic shock had a 12.0% incidence of concurrent hypothyroidism [48]. Furthermore it has been described that in HIV-infected patients there is an increase in the prevalence of hypothyroidism [49].

Also came across this, which shows that Natural Killer cell functionality is impaired in Graves' patients:

jci.org/articles/view/112826

Natural killer (NK) cells were assessed in patients with hyperthyroxinemia due to Graves' disease or treatment with thyroxine (T4). Cytolytic activity was measured with 51Cr-labeled K562 tumor cells and NK enumeration was by flow cytometry using NKH-1 monoclonal antibody to identify the relevant surface marker. Activity was uniformly decreased in association with hyperthyroxinemia, regardless of the underlying pathology; however, there was no reduction in the number of NKH-1+ cells. NK activity was enhanced by addition of interleukin 2 (IL-2) in both control and patients' cells although the value in the latter instance failed to reach the basal control level. Production of IL-2 by lymphocytes from hyperthyroxinemic subjects, in response to phytohemagglutinin, was also reduced. Since NK cells are thought to act as a defense against viral infections and some malignancies and may play a role in autoregulation of the immune system, this effect of T4 may have significant biological implications.

Lots of interesting papers floating around out there!

[greygoose in reply to Hidden]

Yes, but that wasn't the question. The question was: could carbimazole and levothyroxine be a cure for corona virus. There's not really any connection there.

[Hidden in reply to greygoose]

Sorry to bother going to the trouble of finding those papers for you. Won't bother again!

[greygoose in reply to Hidden]

I'm sorry, I didn't know you'd done it just for me. I wasn't asking the question. It isn't my thread.

[Billyboy2u]

It was just a thought. As it’s the storm that kills you. When your Amun system goes into over drive. I was told my system was doing that too. However after the meds started working I was fine and told since your amine system has calmed down now you should feel better ?

Since that’s what happens with the corona virus I just linked the 2.

[greygoose in reply to Billyboy2u]

It's the excess thyroid hormones in a thyroid storm that kill you, not the cytokines. And, you felt better because the carbi lowered your levels of thyroid hormone by stopping your thyroid production of hormones.