High Blood Pressure ... Thyroxine and Ramipril - Thyroid UK

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High Blood Pressure ... Thyroxine and Ramipril

Muelerama profile image
10 Replies

Despite being on 10 mg of Ramipril and 175mg thyroxine.. both taken in the morning ... I can't understand why my blood pressure should be so high..I regularly walk for an hour and a half everyday and run up to 10 miles every Saturday without any effort... I've also started a pure plant based diet from December last year to try and improve things... I'm not severely overweight at 13 stone for a 6-ft 2 male, but I am getting on at 59 😉

My GP is also puzzled why why my calcium levels in my blood are negligible.. we've been testing my bloods for the last 3 months and it's still low...

My parathyroid was tested last month and that is fine.

It's been suggested by "greygoose" to take ramipril a few hours after taking thyroxine... Which I will be doing from today.. sounds like a really good idea..Thank you Greygoose.👍

Any other suggestions most welcome.

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Muelerama
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SlowDragon profile image
SlowDragonAdministrator

Low calcium suggests low vitamin D. Calcium naturally rises when we improve vitamin D

Low vitamin D is EXTREMELY common when on Levothyroxine

For full Thyroid evaluation you need TSH, FT4 and FT3 plus both TPO and TG thyroid antibodies tested. Also EXTREMELY important to test vitamin D, folate, ferritin and B12

Low vitamin levels are extremely common, especially if you have autoimmune thyroid disease (Hashimoto's) diagnosed by raised Thyroid antibodies

Ask GP to test vitamin levels

Do you have autoimmune thyroid disease also called Hashimoto's? Diagnosed by high thyroid antibodies

You may need to get full Thyroid testing privately as NHS refuses to test TG antibodies if TPO antibodies are negative

Recommended on here that all thyroid blood tests should ideally be done as early as possible in morning and before eating or drinking anything other than water .

Last dose of Levothyroxine 24 hours prior to blood test. (taking delayed dose immediately after blood draw).

This gives highest TSH, lowest FT4 and most consistent results. (Patient to patient tip, best not mentioned to GP or phlebotomist)

GP will only prescribe to bring vitamin D up to 50nmol.

Aiming to improve by self supplementing to at least 80nmol and around 100nmol may be better .

Once you Improve level, very likely you will need on going maintenance dose to keep it there.

Test twice yearly via vitamindtest.org.uk

Vitamin D mouth spray by Better You is good as avoids poor gut function.

It's trial and error what dose each person needs. Frequently with Hashimoto's we need higher dose than average

Local CCG guidelines

clinox.info/clinical-suppor...

Government recommends everyone supplement October to April

gov.uk/government/news/phe-...

Magnesium

betterbones.com/bone-nutrit...

medicalnewstoday.com/articl...

livescience.com/61866-magne...

sciencedaily.com/releases/2...

Bone pain

easy-immune-health.com/pain...

Vitamin K2 mk7

betterbones.com/bone-nutrit...

intechopen.com/books/cell-s...

If vitamin D is low, B vitamins may be too. As explained by Dr Gominack

drgominak.com/sleep/vitamin...

Muelerama profile image
Muelerama in reply to SlowDragon

Wow, thanks SlowDragon. That's a shopping list for when I go back in the beginning of February.

Cheers 👍

SlowDragon profile image
SlowDragonAdministrator in reply to Muelerama

NHS unlikely to test Ft3 unless TSH is suppressed

Can see from your profile that you had total thyroidectomy

Research shows 20% Patients with no thyroid can not regain full health on just Levothyroxine

ncbi.nlm.nih.gov/pmc/articl...

Many people after TT need the addition of small doses of T3 prescribed alongside Levothyroxine

Naturally your thyroid use to make 80% T4 and 20% T3

Professor Toft recent article saying, T3 may be necessary for many especially after thyroidectomy

rcpe.ac.uk/sites/default/fi...

Vegan diet is extremely difficult to maintain good iron levels. And virtually impossible to maintain good B12 levels without supplementing daily

todaysdietitian.com/newarch...

Anyone relying solely on Levothyroxine replacement is likely low it vitamins anyway

If not supplementing get tested FIRST before starting on any B vitamins

Private testing via Medichecks if GP or endo won't test everything

High cholesterol is linked to being under treated/low FT3

Have you had cholesterol tested?

Muelerama profile image
Muelerama in reply to SlowDragon

Yes I have had cholesterol done and am on a daily statin and have been for about 8 years...

I also take Lansaprazole as I have suffered with my stomach acid for over 15 years.

I have been informed that Lansaprazole interferes with vitamin b12 uptake so I am taking b12 at night.

SlowDragon profile image
SlowDragonAdministrator in reply to Muelerama

Most hypothyroid patients have low stomach acid

Virtually identical symptoms to high stomach acid...but totally different treatment

You can NOT simply stop any ppi

How close in time to taking Levothyroxine do you take PPI

Should be at least 4 hours away. As should Magnesium, vitamin D, calcium and HRT

Thousands of posts on here about low stomach acid

healthunlocked.com/search/p...

Links about low stomach acid

articles.mercola.com/sites/...

thyroidpharmacist.com/artic...

stopthethyroidmadness.com/s...

healthygut.com/articles/3-t...

naturalendocrinesolutions.c...

Ppi causes low vitamin levels

pulsetoday.co.uk/clinical/m...

gov.uk/drug-safety-update/p...

SlowDragon profile image
SlowDragonAdministrator in reply to Muelerama

NHS link about statins not recommended for anyone whi is still hypothyroid

nhs.uk/conditions/statins/c...

If you have an underactive thyroid (hypothyroidism), treatment may be delayed until this problem is treated. This is because having an underactive thyroid can lead to an increased cholesterol level, and treating hypothyroidism may cause your cholesterol level to decrease, without the need for statins. Statins are also more likely to cause muscle damage in people with an underactive thyroid.

SlowDragon profile image
SlowDragonAdministrator in reply to Muelerama

Long term PPI can lead to low magnesium....and this can badly affect ability to utilise vitamin D

sciencedaily.com/releases/2...

I had similar issue of low vitamin D due to inappropriate prescription for propranolol for 20 years. Propranolol lowers magnesium

Low magnesium can mean it's difficult to start vitamin D supplements until improve low magnesium first

plug profile image
plug

Hi,

I'm also on Ramipril, I take 125mg of thyroxine when I wake, then wait at least 30 minutes before eating or drinking. I then take a 80mg slow release propranolol ,however this is after a 4 hour interval. Before going to bed I then take the Ramipril. This seems to work for me and I have been able to reduce my dose of Ramipril from 10 mg down to 5mg with agreement of the GP. My blood pressure especialy the diastolic had been stubbornly high, I walk each day and are within weight guidelines for my height. BP is now low to moderate where it always was prior to developing hypertension.

Hope you find this helpful.

Muelerama profile image
Muelerama in reply to plug

Hi Plug, I'm interested to know what was your average BP before and after the new regime of taking thyroxine and ramipril at different times?

plug profile image
plug in reply to Muelerama

Hiya,

Before it was usually 156 + over 95+. The diastolic is always the bigger issue for me. Now it is down to low numbers 107 over 77, which is where it always was prior to going hypertensive.

I do have a small aortic aneursymn so I make sure not to overdo things and take time out when needed.

I also found not thinking about BP throughout the day helped, I check it morning and bedtime unless I have a very bad headache and eye pain, which for me is a indicator that it's up. Like you i'm in my fifties and also walk 1-2 hours a day, getting out and about in the fresh air is great and helps loads.

Good luck hope you can get it down to better numbers.

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