Reducing Anti-Thyroidperoxidaseabs in Graves’ disease.

[Alexkjones]

Hi. Does anyone have any advise on how to lower Anti-Thyroidperoxidaseabs antibodies? Had my blue horizon results in and they are higher than last time. They are at 283 KIU/L and they need to be under 34 ! My Anti-Thyroglobulin Abs antibodies are good at 15 kU/l which is well inside the range which needs to be under 115. So its just the Thyroidperoxidaseabs antibodies I need to get down. Open to any ideas on how to do this. 2 years ago my levels where 196. So I’m heading in the wrong direction. Alex

[greygoose]

TPO antibodies are for Hashi's. Do you have Hashi's as well as Grave's? How was your Grave's diagnosed? Do you have high TRAB or TSI?

Why do you think you need to reduce your TPO antibodies? It won't get rid of your Hashi's. TPO antibodies don't attack the thyroid, like so many people seem to thing, they just clean up traces of TPO that leak into the blood during the attack, but they don't do the attacking. And, with or without them, your immune system will continue to attack your thyroid.

[Alexkjones in reply to greygoose]

Thanks for replying. I was diagnosed with graves antibodies by Endo when my tsh was at 0.02 originally but at a later test they did value was zero! Am I right in thinking thats tsi? so these readings from blue hotizon are not related to that right ? I’m not Hashi according to Endo. So what are the 2 readings in the blue horizon results about? Thanks for your help. Alex

[greygoose in reply to Alexkjones]

I don't think your endo knows much about thyroid. So, if I were you, I'd check up on those 'Grave's antibodies'. It might have been TSI, but it might have been TRAB. Then again, it might have been TPO antibodies! Because endos have a nasty tendancy to confuse Grave's with Hashi's.

Those antibody results are saying you have Hashi's. And I'd trust them rather than your endo. You need to clear that up.

[Alexkjones in reply to greygoose]

Very interesting as I had thought I might have Hashi based on my fluctuating weight between the ages of 18-34. Always struggled with my weight but then lost weight and went hyperthyroid. Endo assured me I didn’t have Hashi. So from the blue horizon results that suggests Hashi to you right? I’m seeing Endo in June so will ask her more details then. I have asked before but she said I had the graves antibodies from the special tests they did. What antibodies should I have tested? All of the ones you metion? Tpo, tsi and trab? Alex

[greygoose in reply to Alexkjones]

It's meaningless to just say 'Grave's antibodies', because there's no guarantee that she actually knows what Grave's antibodies are. All antibodies have a name, because they are very specific in their action. So, you need to press to get the name of the antibodies she tested when she diagnosed you.

Grave's antibodies are TSI or TRAB.

Hashi's antibodies are TPOab and TgAB.

You've had the TPOab and TgAB tested and the TPOab are positive. No point in retesting them. They say you have Hashi's.

The question is: did she actually test TSI or TRAB at diagnosis, or did she test TPOab thinking it was for Grave's. As rediculous as that sounds, it happens.

Hashi's can have 'hyper-like' periods, when the dying cells dump their store of hormone into the blood stream, causing FT4/3 levels to rise steeply, and therefore the TSH drops. Many doctors just see the suppressed TSH and automatically think 'Grave's'. But, whilst suppressed is suppressed, and can't get any lower, and will be suppressed with both Grave's and a Hashi's 'hyper' swing, the FT4/3 levels will be different. With a Hashi's 'hyper' swing, the FT4 will typically go up to around 30/35, and the FT3 to around 12. With Grave's, they would be much higher. But, there is so much reliance on the TSH test, that doctors don't tend to look much further than that, or even do the right tests. So, what you need to know is exactly what tests were done that lead to your diagnosis, and exactly what the results were. Not redo them.

Sorry if I'm repeating myself, I'm at that age!

[Alexkjones in reply to greygoose]

That makes perfect sense. I think from memory it was tsi. I know the level was about 4 I think. My t4 at diagnosis was much higher at like 60-70 and t3 was way up too and heart rate etc. I’m gunna do some more homework before I see her in June. Thanks for your knowledgeable advise like always. Alex

[greygoose in reply to Alexkjones]

Ok, so if it was TSI, that's ok. And your FT4 was high. It is possible to have Grave's and Hashi's at the same time - after all, they are both autoimmune diseases. But, I don't know how that works in practice.

[Alexkjones in reply to greygoose]

I’m guessing high Thyroidperoxidaseabs antibodies can be due to graves and or Hashi. ? Still. Is there nothing I can do to lower them? Alex

[greygoose in reply to Alexkjones]

Why do you want to lower them? What do you think they're doing to you?

I'm not sure if you get high TPOab with Grave's. Googling that point gives some very confusing answers.

[ling]

I do not have the info you seek. But I do think you are on the right track in seeking to reduce the high antibodies level. They should be an indication of disease activity and could be wreaking some havoc in your body, the effects of which may show up further down the road. So it would be a good idea to find out more about how to bring the antibodies level down. All the best