I suspect many here will add this to the "state the obvious" collection of papers!
Is anyone reading this in the least surprised by the impact? Certainly the backing up of performance by fMRI adds to the study as compared to our personal experiences and that is good.
However, I do think it is important that what we might consider absolutely day-follows-night should, so far as possible, be backed up with properly conducted studies.
(I have deep reservations as to the ethics of this study. Is it right to knowingly reduce a life-sustaining medicine sufficiently to have significant effects on the subjects?)
J Neuroendocrinol. 2019 Mar 15:e12707. doi: 10.1111/jne.12707. [Epub ahead of print]
Partial withdrawal of levothyroxine treated disease leads to brain activations and effects on performance in a working memory task: A pilot study.
Göbel A1, Heldmann M1,2, Göttlich M1, Georges R3, Nieberding R3, Sartorius A4, Brabant G3, Münte TF1,2.
1 Department of Neurology, University of Lübeck, Lübeck, Germany.
2 Department of Psychology II, University of Lübeck, Lübeck, Germany.
3 Department of Internal Medicine I, University of Lübeck, Lübeck, Germany.
4 Central Institute of Mental Health, Mannheim, Germany.
Hypothyroidism is associated with memory impairments.
The aim of this study was to evaluate the effects of partial withdrawal of levothyroxine on working memory tasks and brain function.
Fifteen subjects under long-term levothyroxine substitution due to complete hypothyroidism participated in this study. A functional MRI was performed using a working memory task (n-back task) and neuropsychological tests were performed before and 52-54 days after the induction of subclinical hypothyroidism by reducing pretest levothyroxine dosage by 30%.
Reaction time of subjects under partial levothyroxine withdrawal was significantly longer and less accurate in solving the working memory tasks. FMRI revealed significant activation changes after medication withdrawal in the cerebellum, insula, parietal, frontal, temporal and occipital lobes, lingual gyrus and the cuneus.
Partial withdrawal of levothyroxine may lead to deficits in a working memory task and to an activation of brain areas associated with working memory ability. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
fMRI ; Hypothyroidism; memory; n-back task; thyroid
Added 14:52 16/03/2019
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