Today Thyroid have published a paper studying the forms of TSH in women. In fertie women, there seems often to be a form of TSH which is unusally large (its also found temporarily in newborns but disappears quite quickly). Exactly how active it is compared with normal TSH I do not know. Also there were quite a large number of cases where anti-mouse antibodies interfered with the test. So a warning that TSH values can be spurious in different circumstances.
Hyperthyrotropinemia in Females of Reproductive Age
Naoki Hattori, Kohzo Aisaka, Kazuhisa Chihara, and Akira Shimatsu
Interesting. Doctors tend to be unaware that TSH comes as a group of isoforms with differing bioactivity. From hypothyroid patients' point of view depression, starvation, severe illness or a down-regulated axis can produce TSH isoforms with reduced activity leading to low normal fT3 / fT4 with a normal TSH. This gives 'normal' blood test results but considerable hypothyroid signs and symptoms. A form of central hypothyroidism that is not recognised.
Just to clarify as I am not sure I understood correctly.The women tested had fertility problems and 17 %of them had these macro Tsh particles. They only tested women with a Tsh of over 2.5. The mice are lost on me completely.
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New research Nov 2015 showing TSH to T4 NOT linear link but multi loop systems involved creating huge variants TSH over rated.
