This study blows the unscientific reference ranges used for diagnosis and treatment out of the water. Worth sharing with doctors who cling to outdated guidelines.
“High individuality causes laboratory reference ranges to be insensitive to changes in test results that are significant for the individual. (...)
A condition with abnormal serum TSH but with serum T4 and T3 within laboratory reference ranges is labeled subclinical thyroid disease. Our data indicate that the distinction between subclinical and overt thyroid disease (abnormal serum TSH and abnormal T4 and/or T3) is somewhat arbitrary. For the same degree of thyroid function abnormality, the diagnosis depends to a considerable extent on the position of the patient’s normal set point for T4 and T3 within the laboratory reference range.”