Ncbi.nih gov Article about T3/T4 combination therapy

[Pascha1]

Just found this article, sorry if it's been posted before

ncbi.nlm.nih.gov/pmc/articl...

[diogenes Remembering]

This is all very well and good, but there is a gaping hole in how useful statstical analysis can be done. It's all very well controlling patients in dosage and so on, but the fact remains that everyone is an individual. One's combination of TSH, FT4 and FT3 results are unique in that they interact together either in health or on treatment (T4 only or T4/T3 combination or NDT). The three results in a patient panel are not random. Given this close related combination, it is simply wrong to combine a random panel of patients together, however well controlled, and try to get meaningful statistical results out of them by simple statistics. The possibilities for artificial correlations or noncorrelations are huge. It's called the Simpson Paradox. The result depends strongly on the mix of patients and their particular dosage regime. To get anything useful, new statistical methods have to be applied. It is this failure of all trials that has led to the inconclusiveness of trials for T4/T3 combination therapy and the likely false links of TSH versus AF and OP. This is a difficult subject, but inadequate analysis has led to false conclusions.

[Hidden]

Hi Pascha. Just read the article. In table 1 toward the bottom the authors have listed criteria for choosing patients for their trial re dosing with both T4 and T3. Under 'Not currently useful' is 'symptom profile.' So we're back to labs trumping symptoms (sorry for using the "T" word). Makes me wonder who funded the trials!!! Along with the general non-supportive tone of the article regarding usefulness of adding T3 this comment, IMO, puts this research back in the dark ages. Unbelievable. And the ncbi.nlm.nih.gov is the main source of medical info in the US. The national institutes of health have the stamp of approval for most of our guidelines in the US. Very discouraging. IMO this article's research will make it that much harder for us to find an endo willing to march to his own drummer. I just hope my new endo doesn't move out of Atlanta. Then I would have to start my search all over again. With a few exceptions I am disgusted with the US healthcare system. Either way-making money (US system) or saving money (NHS system) we're s#@$%^&! There is also a small paragraph about how levo is one of the top drugs prescribed in the US. Big Pharma has long tentacles. I could go on with my critique but it will just raise my pacemaker rate. 😡