Over the years, we have seen many, many test results posted here. Among them, there have been both Total T4 and Free T4.
In the UK, we mostly see Free T4 without Total T4. Some of the private tests in the UK include Total T4 (I think always with Free T4 as well) and it also appears to be reasonably common in some other countries.
The paper I quote below emphasises one of the problems with testing Total T4. That is, some people need far higher levels of Total T4 simply in order to keep Free T4 at an appropriate level.
Of course, Total T4 can still change over time and that change might be of some interest. But if you check against any reference range, it will look far, far too high. I think we can all imagine having our doses adjusted on this false basis.
Thyroid. 2018 Apr 20. doi: 10.1089/thy.2017.0564. [Epub ahead of print]
Homozygous Mutation in Human Serum Albumin and Its Implication on Thyroid Tests.
Mimoto MS1, Karaca A2, Scherberg N3, Dumitrescu AM4, Refetoff S5.
Author information
1 University of Chicago, Endocrinology, Diabetes and Metabolism , 5841 S. Maryland Avenue, MC 1027 , Chicago, Illinois, United States , 60637 ; mizuho.mimoto@uchospitals.edu.
2 Massachusetts General Hospital, 2348, Endocrine Unit, Boston, Massachusetts, United States ; akaraca@mgh.harvard.edu.
3 The University of Chicago, Department of Medicine, Chicago, Illinois, United States ; nscherbe@medicine.bsd.uchicago.edu.
4 The University of Chicago, Department of Medicine , 5841 S. Maryland Ave MC3090 , Chicago, Illinois, United States , 60637 ; alexd@uchicago.edu.
5 The University of Chicago, Medicine , 5841 South Maryland Avenue , MC 3090 , Chicago, Illinois, United States , 60637-1470 ; srefetof@uchicago.edu.
Abstract
An individual with familial dysalbuminemic hyperthyroxinemia (FDH) due to a homozygous mutation (c.653G>A, p.R218H) in the human serum albumin (HSA) gene is reported. The patient was identified during evaluation of abnormal thyroid tests in a large family with multiple levels of consanguinity. He showed a greater increase in total T4 relative to that observed in heterozygous family members. The higher affinity of mutant HSA for T4, together with the large molar excess of HSA relative to thyroid hormones in serum, results in preferential association of T4 with the mutant rather than wildtype HSA in heterozygous individuals. The two-fold greater amount of T4 bound to the mutant HSA in the homozygote, relative to heterozygotes, is an adaptive requirement to maintain a normal free T4 concentration.
PMID: 29676214
DOI: 10.1089/thy.2017.0564