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Thyroid UK
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Hyperthyroidism and ankle swelling?

I have relapsed for 3rd time with hyperthyroidism i.e. November 2017. Each time I have experienced rapid heart rate. Until recently just before being prescribed betablockers when sitting my heart rate ranged from 95 to 115. When standing still it ranged from 125 to 166.

Whilst beta blockers have helped to slow heart rate i find that they wear off 4 hours before next tablet has to be taken.

(Currently on 10mg of propranolol 3 times a day & 20mg of carbimazole.)

Since Nov 2017 as well as thyroid symptoms I have also had swelling in my left ankle. I mentioned to Dr back in Nov 2017 and he requested that i have a CA125 test which came back abnormal (0-35 is normal range) but my result was 66. As it was out of range Dr then sent me for a pelvic ultrasound scan which involved checking ovaries, kidneys, liver, tummy and aorta. All was normal.

The thing is I am still experiencing this swollen ankle. I saw Dr again about it, asking could it be because of my thyroid and could there be any link to the rapid heart beat. He didnt say but instead sent me for repeat CA125. The result was confirmed this week i.e. 46 and I was told this is is satisfactory. I don't have actual results of thyroid test redid last week but was advised I'm hyperthyroid but that results whilst still out of range, had improved.

Has anyone else experienced swollen ankle? Could it be thyroid condition that is causing it?

In the meantime I dont know where to go next with this.

5 Replies


I'm sorry you've had no replies. Google "Pretibial myxoedema" images to see whether the swelling is similar.

Ask your GP receptionist for a printout of your thyroid results and ranges and post them in a new question for advice.


Hi Clutter thanks very much for your reply. I checked the images but mine looks more like swelling and has no skin like rash. Up until my relapse in Nov I was at gym 6 times a week so was really fit and was surprised at the swelling appearing. Thats why i wondered if it was related to thyroid condition.

I saw GP today and he thinks it is now just down to something that women over 40 can generally be bothered with. He said there is no treatment for it and advised not to take water tablets.

Then later today my endo consultant phoned so I asked her about it and she said that she has seen cases of patients with ankle swelling but it is not a common symptom. It was reassuring to hear that in those cases she has seen swelling disappear once thyroid has become normal. Fingers crossed!

She was able to confirm blood test results which have improved since January. T4 was 41 & now 28. TSH was fully suppressed and now 0.27. She said that my condition is caused by antibodies but when i asked what antibodies test result was she said that she hadn't tested for this. She has based it on history.

This site is so interesting and more informative I think than any information I have got from Drs.




You're still hyperthyroid to have T4 28 but it's good news that TSH has risen. It sometimes takes months/years for TSH to respond.

I hope the swelling subsides when T4 drops into range.



Hi Karenc27

Sorry - I didn't look in on the site yesterday so missed your post.

Yes, I had swelling in both feet and ankles when seriously ill with Graves. I was given water tablets to help with getting rid of the fluid in addition to heart meds and carbimazole. I also had pretibial myxoedema which was like really flaky, dry, itchy rash on my shins. My consultant said it was all related to my heart being unable to function properly because it was going at 200 miles per hour! Or was it because I was a woman over 40 years of age at the time 😜 ?

Once my levels came down to within normal ranges, the swelling disappeared and never returned.

I am pleased that your levels are heading in the right direction. I’m pretty sure the swelling will go down as your levels continue to improve.

I wish you well.


Mrs Graves, thanks so much for your message. As you have experienced it its so encouraging to hear that it really does go away. I hope you are doing well and keeping on top of your thyroid condition.


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