Paper from Stop the Thyroid Madness facebook page today with a paper on T4/T3 combination therapy.
Due to progress in basic and clinical research, we now
have a better but by no means full understanding why
T4 monotherapy may not work in all patients and why
T4+T3 combination therapy may work in some patients. It
is biologically plausible that particular polymorphisms in
thyroid hormone transporters and deiodinases are causally
related to persistent complaints during T4 monotherapy,
but proof that T4+T3 combination therapy will alleviate
such complaints is lacking.