Carcinogenic risk and Bisphenol A exposure: A focus on molecular aspects in endoderm derived glands

The other day I posted about bisphenol and till receipts. This paper suggests some extremly important possible effects of Bisphenol A. Doesn't seem like something I want floating around my pockets...

As always, it is research paper - nothing is definite.

healthunlocked.com/thyroidu...

Mol Cell Endocrinol. 2017 Jan 19. pii: S0303-7207(17)30040-0. doi: 10.1016/j.mce.2017.01.027. [Epub ahead of print]

Carcinogenic risk and Bisphenol A exposure: A focus on molecular aspects in endoderm derived glands.

Cuomo D1, Porreca I2, Cobellis G3, Tarallo R4, Nassa G5, Falco G6, Nardone A7, Rizzo F4, Mallardo M8, Ambrosino C9.

Author information

1IRGS, Biogem, Via Camporeale, 83031 Ariano Irpino, Avellino, Italy; Department of Science and Technology, University of Sannio, via Port'Arsa 11, 82100 Benevento, Italy.

2IRGS, Biogem, Via Camporeale, 83031 Ariano Irpino, Avellino, Italy.

3Department of Experimental Medicine, Sez. Bozzatti, II University of Naples, 80138 Napoli, Italy.

4Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry "Schola Medica Salernitana", University of Salerno, 84081 Baronissi, SA, Italy.

5Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry "Schola Medica Salernitana", University of Salerno, 84081 Baronissi, SA, Italy; Genomix4Life srl, Department of Medicine, Surgery and Dentistry "Schola Medica Salernitana", University of Salerno, Baronissi, SA, Italy.

6Department of Biology, University of Naples "Federico II", Napoli, Italy.

7Department of Public Health, University of Naples "Federico II", Napoli, Italy.

8Molecular Medicine and Medical Biotechnologies, University of Naples "Federico II", Napoli, Italy.

9Department of Science and Technology, University of Sannio, via Port'Arsa 11, 82100 Benevento, Italy. Electronic address: coambros@unisannio.it.

Abstract

Epidemiological and experimental evidence associates the exposure to Bisphenol A with the increase of cancer risk in several organs, including prostate. BPA targets different pathways involved in carcinogenicity including the Nuclear Receptors (i.e. estrogen and androgen receptors), stress regulated proteins and, finally, epigenetic changes. Here, we analyse BPA-dependent carcinogenesis in endoderm-derived glands, thyroid, liver, pancreas and prostate focusing on cell signalling, DNA damage repair pathways and epigenetic modifications. Mainly, we gather molecular data evidencing harmful effects at doses relevant for human risk (low-doses). Since few molecular data are available, above all for the pancreas, we analysed transcriptomic data generated in our laboratory to suggest possible mechanisms of BPA carcinogenicity in endoderm-derived glands, discussing the role of nuclear receptors and stress/NF-kB pathways. We evidence that an in vitro toxicogenomic approach might suggest mechanisms of toxicity applicable to cells having the same developmental origin. Although we cannot draw firm conclusions, published data summarized in this review suggest that exposure to BPA, primarily during the developmental stages, represents a risk for carcinogenesis of endoderm-derived glands.

Copyright © 2017. Published by Elsevier B.V.

KEYWORDS:

Bisphenol A; Nuclear receptors; Pancreatic cancer; Prostate cancer; Stress/NF-kB pathway; Thyroid cancer

PMID: 28111205

DOI: 10.1016/j.mce.2017.01.027

ncbi.nlm.nih.gov/pubmed/281...

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  • Having a clean up of unanswered posts. :)

    xx