I have been taking Thyroid medication for a number of years now, & have always suffered with my weight. I've been on numerous diets, but nothing seems to work because of my hypothyroidism. I should mention that several members of my family have hypothyroidism & also diabetes is in the family. Over the past 2 years I have developed trouble with my knees. I exercise 2 to 3 times a week, but it is difficult to motivate myself as my energy levels are very low. I work full time, & I also keep an eye on my elderly mother, who I visit every day. I get very little me time, so I am constantly tired. Just before I started having knee trouble my medication was reduced from 150mcg to 125mcg, & I wondered whether this could have any bearing on it.