I'm sure this has been posted before but re-reading it this morning and feeling a range of emotions.. Happy that there is something in writing that I can show my doctors... But frustrated because I know that it won't be acknowledged. Thinking of printing this and taking it to my recurrent miscarriage clinic appointment on Monday.
I'm on 25mg levothyroxine at the moment but think I should be on 50mg when I'm pregnant due to my high levels of antibodies and borderline tsh levels.
The paper described below is a summary of all the studies published on the relationship between thyroid antibodies and miscarriage.
Association between thyroid autoantibodies and miscarriage and preterm birth: meta-analysis of evidence
BMJ 2011; 342 doi: dx.doi.org/10.1136/bmj.d2616
To evaluate the association between thyroid autoantibodies and miscarriage and preterm birth in women with normal thyroid function. To assess the effect of treatment with levothyroxine on pregnancy outcomes in this group of women.
30 articles with 31 studies (19 cohort and 12 case-control) involving 12 126 women assessed the association between thyroid autoantibodies and miscarriage. Five studies with 12 566 women evaluated the association with preterm birth. Of the 31 studies evaluating miscarriage, 28 showed a positive association between thyroid autoantibodies and miscarriage. Meta-analysis of the cohort studies showed more than tripling in the odds of miscarriage with the presence of thyroid autoantibodies (odds ratio 3.90, 95% confidence interval 2.48 to 6.12; P<0.001). For case-control studies the odds ratio for miscarriage was 1.80, 1.25 to 2.60; P=0.002). There was a significant doubling in the odds of preterm birth with the presence of thyroid autoantibodies (2.07, 1.17 to 3.68; P=0.01). Two randomised studies evaluated the effect of treatment with levothyroxine on miscarriage. Both showed a fall in miscarriage rates, and meta-analysis showed a significant 52% relative risk reduction in miscarriages with levothyroxine (relative risk 0.48, 0.25 to 0.92; P=0.03). One study reported on the effect of levothyroxine on the rate of preterm birth, and noted a 69% relative risk reduction (0.31, 0.11 to 0.90).
The presence of maternal thyroid autoantibodies is strongly associated with miscarriage and preterm delivery. There is evidence that treatment with levothyroxine can attenuate the risks.