I have a Dr. appt on Wednesday 3/9. She finally (out of the blue) decided to test me for TPO antibodies...and lo and behold it was off the charts (in the 300s!!). I am looking forward to my appt because I have known for years that I have Hashimotos but finally had the test done. Ive been on 100 mg of levothyroxine for at least 8 years and I have now started noticing some changes that i thought were menopause related (Im 52). My legs are SUPER achy, Im fatigued, forgetful (cant remember why I walked into a room), and very moody. All of which were attributed to my menopause. Not sure if she will change my med dose or completely switch but anything is better than the symptoms. I am hoping that once my dosage is regulated my legs will be better. I used to run on the treadmill...not I dread even walking on it.