Hi, I was just recently prescribed Levothyroxine at 100 mcg a day. My last TSH was 5.96. The first Endo that I saw almost started me on a 25 dose when TSH was like 5.25 and then she consulted with an Endo who specializes in bone and they decided not to. If those Drs had a problem with a 25 dose then wouldnt a 100 mcg a day be too high? Im 44 yrs old and very overweight. I don't know if that factors in, but I assume it does in configuring dosages.