Hypothyroidism is one of the most common endocrinopathies worldwide, and its incidence is increasing rapidly. It is frequently found to coexist with both type 1 and type 2 diabetes mellitus.[4,5] Cross-talk between thyroid and diabetes has been the topic of many reviews, which discuss the potential of hyperthyroidism to exacerbate diabetes, and of antidiabetic therapy (metformin) to improve thyroid function. The potential role of hypothyroidism in precipitating hypoglycemia has not been highlighted adequately in current literature. This brief communication aims to discuss the link between hypothyroidism and hypoglycemia, and suggest simple caveats for clinical practice.