Doubling of thyroxine dose - is this wise? - Thyroid UK

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Doubling of thyroxine dose - is this wise?

SparklyT profile image
6 Replies

Hello, hoping for some advice!

About 8 weeks ago my TSH was over 100 and my free T4 was 3.0. My consultant put me on 50mcg of thyroxine and my results 8 weeks later were a TSH of 15.2 (range 0.25-5) and Free T4 of 14.6 (range 9-23).

My consultant has recommended doubling my TSH to 100mcg. I however think is too high a dose - the last time I was on this level my TSH became completely suppressed, and my Free T4 went to 33.5! I lost 4kgs in 2 weeks and became very jittery!

The background to this is that I need to get my levels stable before I start on a second round of IVF. I need to get my TSH to below 2 ideally and my free T4 in range.

I have therefore started taking 75mcg as opposed to the 100mcg he recommends (by splitting the pills), and am having no ill effects. However, I'm wondering should I just follow his advice to take the 100mcg and that perhaps it was the fact that I went straight from 100mcg from nothing last time that caused me this ill effects and my swing to overactive.

Be grateful for any thoughts.

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SparklyT
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6 Replies
jimh111 profile image
jimh111

75 mcg seems appropriate based on the above numbers.

Clutter profile image
Clutter

Sparkly, I think 75mcg is right too. If you feel symptomatic you could increase to 75/100 alternate days after 4 weeks. Better to do it gradually than overshoot and become hyper. I was over replaced and FT4 was >32 for 7 months. Not a good time at all.

in reply toClutter

I fully agree with above Sparkly.

Only you know how you feel and increasing slowly can only have better long lasting consequences.

I find recording my temperature every am & pm helps to monitor under or over medication and gives me confidence.

Good luck

Flower007

Kel8 profile image
Kel8

I think it's always better to increase gradually. I was diagnosed with around the same results as you but although I ended up on 150mcg levo, I had to go up very slowly as always feel hyper for about 2 weeks when I increase. You may end up needing the 100 but best to see how you get on with the 75 first. Good luck.

SparklyT profile image
SparklyT in reply toKel8

Thanks very much for this. Did you wait the standard 6 weeks before each increase, or did you go quicker than this?

Kel8 profile image
Kel8 in reply toSparklyT

Yes, I waited the standard 6 weeks each time. I found I had a pattern of - increase then feel hyper for a 1-2 weeks, better for a couple of weeks and then back to feeling hypo so I knew I needed to increase again.

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