Why should what is claimed to be someone with normal thyroid function improve when taking levothyroxine? And worsen when it is stopped? Is it the very definition of normal thyroid function they are using?
Case Rep Psychiatry. 2015;2015:678040. doi: 10.1155/2015/678040. Epub 2015 May 11.
Levothyroxine Augmentation in Clozapine Resistant Schizophrenia: A Case Report and Review.
Seddigh R1, Azarnik S2, Keshavarz-Akhlaghi AA1.
• 1Mental Health Research Center, Iran University of Medical Sciences, Tehran, Iran.
• 2Shahid Rajaie Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
There are many reports that show different thyroid abnormalities in schizophrenia without clear establishment of their role in etiology and treatment outcome of schizophrenia. Among these reports, there are only a few that consider a role for thyroid hormones as augmenting agents in the treatment with antipsychotic drugs. This case report outlines symptom subsidence of a patient with clozapine refractory paranoid schizophrenia and normal thyroid function who added levothyroxine to clozapine and found that symptoms of psychosis returned once levothyroxine was discontinued. Although this observation needs to be confirmed in controlled clinical trials, we aimed to discuss possible hypothesized mechanisms underlying this observation.
PMID: 26078905 [PubMed]