After over 2 years of various doses and types of thyroid medication with only transitory success I have decided to tackle my adrenals. I bought some pregnisilone while on holiday in Turkey for 75p a box of 20 5mg tablets and am not sure how to take it. I have started with 2.5mg daily which I am taking at night with all my other meds. I tried to increase to 5mg but felt very jittery. How long untill I start to feel better and how long untill I try to increase again. Do I take my thyrogold in the morning as usual at the same dose as before or do I start with a low dose of thyroid meds and work up with the steroid med. How do I know if its working.