Because of the solid and sensible advice and information I have been given via this forum, and because my last free T3 result was considerably lower in range compared to my free T4 result (3.8 (3.5-5.5) vs 18.7 (10-19.8)), I have decided to trial a combination T3/T4 therapy and see if that makes me feel better. Many thanks to all of you who have got me this far and given me the necessaries to talk to my GP so that she understands why I would like to do this.
My question is this: what possible side effects should I expect and how long might they last? I will be taking 100 mcg levothyroxine and 12.5 mcg Tiromel per day; I currently take 150 mcg levothyroxine only. In addition, I have been advised that to begin with, at least, I should split the Tiromel dose so would it be best to take half in the morning and half at lunchtime?
My last question (I have so many!) is how long it might take for me to start feeling better. At the moment, although my free T4 would appear to be fine I am slowly sinking into a state of depression, of which I have a history (and bipolar disorder on top of that, it's quite the collection) and am feeling emotionally disconnected to my children and husband, everybody really. There's a feeling of desperate despair and I am mentally exhausted, although the body seems more or less content to carry on. I do believe strongly that this latest depressive bout is connected to my low T3. Now I think about it, I was diagnosed with hypothyroidism at 19 and had my first major depressive episode at 20. Maybe they're connected, maybe not. Both mental illnesses and thyroid disorders run in my family.