I have a TSH of 8 and my GP prescribed levothyroxine 50 mg. I took the first dose yesterday morning before breakfast. No other advice given. Within hours I had diarrhoea, nausea and eventually vomiting and had no sleep at all last night. I was cleaning cupboards at 2 in the morning and came into work at 5 am. I am still not even tired and very restless Any advice out there? Has anyone else reactive so violently on day 1?