Hope: prebiotic by Novensis out end of April (hopefully)

[LFHell]

I took part in a research study recently for a prebiotic sugar found in breast milk that increases bifido bacteria. I just wanted to update you that altho it was a double blind trial, i could tell i was taking the real thing the first month (100% sure) because my gut felt soooo happy! Also the placebo was maltodextrin which she said was innocous but i felt shit on it and missed some near the end - i googled it and its an artificial sugar and one study linked it to IBD - as most emuslfiers/sweeteners are - they all damage the gut biome.

[We have poisoned by supermarket and then they wonder why we have IBS?? That is my opinion!!]

"The links to the prebiotic studies are below.

onlinelibrary.wiley.com/doi...

Human milk oligosaccharide supplementation in irritable bowel syndrome patients: A parallel, randomized, double‐blind, placebo‐controlled study - Iribarren - 2020 - Wiley Online Library

Supplementation with a mix of 2’-O-fucosyllactose and Lacto-N-neotetraose (2’FL/LNnT) in IBS patients was well tolerated and increased bifidobacteria abundance. Supplementation with 2’FL/LNnT can res...

onlinelibrary.wiley.com

pubmed.ncbi.nlm.nih.gov/335...

The prebiotics are called human milk oligosaccharides and are currently only being sold for infants, but a new product should be on the shelves in the next few months from a company called Novonesis. Nestle and DSM will also likely follow with similar products."

Researcher

[Aegis52]

Hello there. That looks very interesting. I have tried Alflorex which improved symptoms of constipation initially. Is this new product more effective that increasing the Inulin content of one’s diet, and are there side-effects? My view of probiotics was changed by a scholarly study done in rats which suggested that long term use of probiotics hade adverse effects on the colon and anti inflammatory markers in the blood. Notwithstanding, I’ ll look out for this product. Best wishes

[Aegis52]

This is the study to which I alluded in my posting.

sciencedirect.com/science/a...

A bit disturbing!

[xjrs in reply to Aegis52]

I read that study but they also say:

It is becoming increasingly clear that the effect of a probiotic strain is species- and strain-specific and it cannot be extrapolated to all probiotics..

there is an increasing tendency to work with multi-strain probiotics, which health effects are derived from single strain characteristics...

our probiotic mix contained lactobacilli strains with different immunomodulatory properties..

inflammatory cytokines, increased IL-10 tissue level possibly as a result of the body attempting to decrease an excessive inflammatory response accompanied by increased abundance of various groups of bacterial families associated with the promotion of gastrointestinal inflammation and/or other diseases including diabetes or stroke.

the choice of an appropriate probiotic mixture should not be based on the number of strains in the product but rather on evidence gained from well-designed research experiments of probiotic efficacy during specified treatment period

Alflorex is a single strain probiotic which is based on Bifdobacterium and not Lactobacilli. When I looked into long term use of Bifdobacterium it suggested it reduced inflammation rather than being pro-inflammatory. As the study says it is down to the specific characteristics of the bacteria in the probiotic.

[Aegis52 in reply to xjrs]

Thanks for the comments. Could you possibly furnish me with the links to the studies relating to long term use of bifidium, please? Best wishes

[xjrs in reply to Aegis52]

I didn't record the studies, but I've just done the search again.

frontiersin.org/journals/mi...

It has been reported that intervention with Bifidobacterium infantis conditioned medium in mice significantly reduced their colon permeability, while the long-term use alleviated the inflammatory response in IL-10 deficient mice, restored colon permeability to a normal level, and reduced the secretion of interferon in the colon

pmc.ncbi.nlm.nih.gov/articl...

pmc.ncbi.nlm.nih.gov/articl...

e-century.us/files/ijcem/10...

Long-term use of Bifidobacterium longum alleviates colorectal colitis in rats by regulating inflammatory cytokines and Treg cells

[Aegis52 in reply to xjrs]

Thank you very much, I appreciate your response. Best wishes

[xjrs]

Thanks for this information and for taking part in the study. Good that it helped you.

It will be interesting to see how others get on with it since it is a prebiotic and sometimes people with dybiosis / gut bacterial imbalance don't do well on prebiotics, as they end up feeding their dominating bad bacteria. Considering that oligosaccharides are a FODMAP, it may also depend on how someone gets on with oligosaccharides.

[BabsyWabsy]

This is fascinating stuff. I'm a serial breast feeder and former support group leader and teacher, I am curious as to where the supply of suitable breastmilk is coming from. As you probably know, it can be very variable, dependant on the age/stage of the child and its needs. Could this result in synthesis of the relevant ingredient(s)?