Hope: prebiotic by Novensis out end of April (hopefully)

[LFHell]

I took part in a research study recently for a prebiotic sugar found in breast milk that increases bifido bacteria. I just wanted to update you that altho it was a double blind trial, i could tell i was taking the real thing the first month (100% sure) because my gut felt soooo happy! Also the placebo was maltodextrin which she said was innocous but i felt shit on it and missed some near the end - i googled it and its an artificial sugar and one study linked it to IBD - as most emuslfiers/sweeteners are - they all damage the gut biome.

[We have poisoned by supermarket and then they wonder why we have IBS?? That is my opinion!!]

"The links to the prebiotic studies are below.

onlinelibrary.wiley.com/doi...

Human milk oligosaccharide supplementation in irritable bowel syndrome patients: A parallel, randomized, double‐blind, placebo‐controlled study - Iribarren - 2020 - Wiley Online Library

Supplementation with a mix of 2’-O-fucosyllactose and Lacto-N-neotetraose (2’FL/LNnT) in IBS patients was well tolerated and increased bifidobacteria abundance. Supplementation with 2’FL/LNnT can res...

onlinelibrary.wiley.com

pubmed.ncbi.nlm.nih.gov/335...

The prebiotics are called human milk oligosaccharides and are currently only being sold for infants, but a new product should be on the shelves in the next few months from a company called Novonesis. Nestle and DSM will also likely follow with similar products."

Researcher

[Aegis52]

Hello there. That looks very interesting. I have tried Alflorex which improved symptoms of constipation initially. Is this new product more effective that increasing the Inulin content of one’s diet, and are there side-effects? My view of probiotics was changed by a scholarly study done in rats which suggested that long term use of probiotics hade adverse effects on the colon and anti inflammatory markers in the blood. Notwithstanding, I’ ll look out for this product. Best wishes

[LFHell in reply to Aegis52]

oh seriously? Thats scary, do you have the link to the study?

This is a prebiotic (which is not the same as probiotic as its a dietary component), its a long chain sugar, synthesised in a lab but identical to a sugar found in breast milk. Its increases bifido bacteria reliably in studies which is one of the best bacterias which we have a lot of at birth but decreases with age. From what i've read having good bacteria present in the gut, can prevent the bad bacteria taking hold. I loved it, and definately noticed more of a difference than with probiotics.

But i do recommend Vivomixx infant drops (i only take 5 a day) and do notice a little improvement in symptoms on them but they make me bloated also i think. tho hard to tel anymore as i'm always bloated. maybe they arnet good for you but those are the ones i liked best. As i know streptococcus thermophilus is the only one to stay in my gut after taking probiotics, from biome testing... Tho it was quite a high amount - 1%.. but i did have better diversity then too! And now i dont. (from doing an allergy diet and no probiotics then)

[Aegis52]

This is the study to which I alluded in my posting.

sciencedirect.com/science/a...

A bit disturbing!

[xjrs in reply to Aegis52]

I read that study but they also say:

It is becoming increasingly clear that the effect of a probiotic strain is species- and strain-specific and it cannot be extrapolated to all probiotics..

there is an increasing tendency to work with multi-strain probiotics, which health effects are derived from single strain characteristics...

our probiotic mix contained lactobacilli strains with different immunomodulatory properties..

inflammatory cytokines, increased IL-10 tissue level possibly as a result of the body attempting to decrease an excessive inflammatory response accompanied by increased abundance of various groups of bacterial families associated with the promotion of gastrointestinal inflammation and/or other diseases including diabetes or stroke.

the choice of an appropriate probiotic mixture should not be based on the number of strains in the product but rather on evidence gained from well-designed research experiments of probiotic efficacy during specified treatment period

Alflorex is a single strain probiotic which is based on Bifdobacterium and not Lactobacilli. When I looked into long term use of Bifdobacterium it suggested it reduced inflammation rather than being pro-inflammatory. As the study says it is down to the specific characteristics of the bacteria in the probiotic.

[Aegis52 in reply to xjrs]

Thanks for the comments. Could you possibly furnish me with the links to the studies relating to long term use of bifidium, please? Best wishes

[xjrs in reply to Aegis52]

I didn't record the studies, but I've just done the search again.

frontiersin.org/journals/mi...

It has been reported that intervention with Bifidobacterium infantis conditioned medium in mice significantly reduced their colon permeability, while the long-term use alleviated the inflammatory response in IL-10 deficient mice, restored colon permeability to a normal level, and reduced the secretion of interferon in the colon

pmc.ncbi.nlm.nih.gov/articl...

pmc.ncbi.nlm.nih.gov/articl...

e-century.us/files/ijcem/10...

Long-term use of Bifidobacterium longum alleviates colorectal colitis in rats by regulating inflammatory cytokines and Treg cells

[Aegis52 in reply to xjrs]

Thank you very much, I appreciate your response. Best wishes

[xjrs]

Thanks for this information and for taking part in the study. Good that it helped you.

It will be interesting to see how others get on with it since it is a prebiotic and sometimes people with dybiosis / gut bacterial imbalance don't do well on prebiotics, as they end up feeding their dominating bad bacteria. Considering that oligosaccharides are a FODMAP, it may also depend on how someone gets on with oligosaccharides.

[LFHell in reply to xjrs]

This is a prebiotic found in breast milk tho, so i think it's one our body copes with better.. Apparently most people on the study could identify the prebiotic correctly as opposed to the placebo (we did both and was double blind). I dont do well with any fodmaps usually and i didnt cope well with the maltodextrin they used as the placebo.. and suffered for about a month after. I confess i've been eating out a lot at weekends since the study finished and haven't had too bad symptoms, i seem to be able to cope with small amount of fodmaps now, may not be related to the study tho, maybe just because i was forcing myself to eat them as i have no time to cook right now. And maybe getting bit more exercise too going into town at wknds.

Are lactobaccillus bactera pro-inflammatory? I've never found any of them work! But i do like vivomixx and think it helps a bit with cheese allergy as i notice it gets worse when i stop them.

[xjrs in reply to LFHell]

The study seemed to suggest some lactobaccillus may be pro-inflammatory in the long term but I don't think it said specifically which. I wouldn't dare try Vivomixx due to the very high CFU and not getting on with high CFU probiotics in the past. I think I'll stick with the Alflorex which is a lower CFU and 1 strain.

[BabsyWabsy]

This is fascinating stuff. I'm a serial breast feeder and former support group leader and teacher, I am curious as to where the supply of suitable breastmilk is coming from. As you probably know, it can be very variable, dependant on the age/stage of the child and its needs. Could this result in synthesis of the relevant ingredient(s)?

[LFHell in reply to BabsyWabsy]

The prebiotic (sugar) is synthesised in a lab, so its not coming from human milk but is identical to the sugar found in breast milk. I took something similar in the past helio something but didnt notice that working much! And it was expensive. This should be a reasonable price... as they've waived the patent.

[BabsyWabsy in reply to LFHell]

Interesting. Was it oligosaccharides rather than simple lactose? If so, did it give you wind?

[LFHell in reply to BabsyWabsy]

Yes its a human oligosaccharide though rather than a plant one. It gave me slight gas at start but not like trapped gas, it escapes! It just made my stomach feel better and i am eating much more than i used to with less effects now, tho still on low fodmap diet strictly during the week but i do have takeaway most weekends now and used to get a lot of pain if did that but symptoms milder now. (not planning to do that forever, just been busy and its been easier not cooking at weekends).

[LFHell in reply to BabsyWabsy]

The researcher has sent me some more prebiotic for free (it should be out next monht i hope) but i only started taking it this week. Not noticing the stomach having a smiling-emoticon so much but i do feel better as was getting more pain and discomfort in January from eating out and thats stopped now.

[BabsyWabsy in reply to LFHell]

I am so pleased that you have found some relief. A very interesting development. Do keep us posted about how it progresses.