Need help with duloxetine diarrhea

[colourfulsevens]

Hi everyone. Not sure where else to turn.

Conditions I have:

Coeliac disease

IBS

Depression, anxiety

On the afternoon of December 10th, I took a single 30mg duloxetine tablet. I was immediately drowsy and tired, and then extremely nauseous for hours. I never vomited but I stopped taking the tablet immediately. The nausea then gave way to explosive and extreme diarrhea, which took six days to calm down. I'm no longer having explosive diarrhea but my stools are still very soft and there are bits of undigested food in there. I've also been incredibly irritable, I've burping frequently and intensely throughout the day (in a way I never have done before), and on the morning of December 15th I was briefly suicidal.

As I've said - my diarrhea has calmed down now and I'm not as irritable nor am I suicidal, but my stools are still very soft. It's worth mentioning that I've been taking Loperamide on a daily basis for six years to aid my IBS symptoms, and according to this site (drugbank.ca/drugs/DB00476) it delays the process by which the body metabolises duloxetine. Is there a chance I could still be suffering from side effects, or even withdrawals, from an extreme reaction to duloxetine? Or is this something else?

[Kilgh]

It's not a side effect the drug is known for. Unless there was gluten in the tablet you took? Otherwise I wouldn't be sure anything other than the drowsiness would be related to it myself. But you should be consulting your doctor on this. I also didn't see any issue with taking loperamide at the same time. Delaying the drug entering your bloodstream shouldn't cause any worse side effects. It just takes longer to get to your brain. Could you have had a co-incidental infection?

[jackdoor in reply to Kilgh]

Been taking 60mg Duloxetine for 2 months it gave me constipation not the trots and my chest has swollen up a bit they look a bit like man boobs nipples are sensitive too, going the doctors in 2 weeks anyway see what she says