After having my symptoms under control on a combination of mebeverine & amitryptiline for about 5 months I was feeling great! Then a couple of weeks ago I went on my Honeymoon to Mexico. I was really cautious with the food and only drank bottled water. I had a bit of heat exhaustion and bam persistent diarrhoea. So I spent most of my honeymoon in close proximity to a loo in constant fear of eating anything! Since bring home I've swung from being constipated and having dirrahoea. I really thought I had things under control & now I feel like I'm back to square 1! I seem to be fine one minute and then pain, massive gargle and mass evacuation. Not even sure where to go from here! The spasms also make my hands go numb! Anyone get that?