So 1 week on from starting this drug for ibs d with severe stomach cramps mostly all first thing in the morning then calming down a little as the day goes on. Results after 1 week iv been able to sleep through the night til my normal getup time of 7am without any rude awakenings. However im still having to take 2 buscopan as soon as i wake and still having several diarrhoea episodes although not quite so explosive. So id say so far its helped calm things down very slightly. My bowel back and belly are still very tender but i dont feel as terrible and lethargic as i have for the past fortnight although still shattered by 8pm. Still having to take 2 codeine 30/500mg around 10am for back pain after a morning on the toilet. And still eating a minimal and plain diet to try and get through this flare up. Just thought i would update for anyone else thinking of trying amitryptaline.