Experiences with

Zytiga

My dad just stopped his Zytiga due to nausea, and other intolerable side effects. He just got his first two shots that they give for osteoporosis...due to a spontaneous fracture in his pelvis.

Trying a half dose of Zytiga? Is it time to start thinking about chemotherapy agents? Thanks all, I just want to make sure I'm doing everything I can for my father.

I was dx in Oct 2021 with Gleason 8, t3a, N1,M0 grade IV PC received 39 radiation treatments after3 mos of firmagon and Zytiga. PSA is undetectable. MO has agreed to 24 mos ADT since I had a clean bone scan originally, lymph nodes do not show disease now. Tumor was outside prostate on MRI.

He’s been on generic Zytiga and prednisone and Lupron and finished six weeks of IMRT. Three months after the IMRT his PSA dropped to .07 and now it’s .01. We all live from test to test and I just hope and pray the good news keeps coming. He’s only 50 years old and he’ll be 51 in August.

I am on Lupron and Zytiga. Anyone else have the same issue? No radiation yet.

Now that I am "back to normal" and the only longer term side effect so far is that my white blood cell count (WBC) is on the low side, but it's been low ever since I did the 18 months of Zytiga in 2019. I'm optimistic it will continue to rise over time.

From a therapeutic point of view, I painting the cliff face in sections to reflect my journey with PCa: (a) to the far right we have the time before diagnosis, (b) then between diagnosis and failed brachiotherapy to failed surgery; (c) then follows my increasingly chaotic journey from Zytiga to Xtandi

I’m worried about trying it while my husband is still responding to Zytiga and feeling so good. I can’t find any data on use when PSA is still low and responding to ADT, though Duke says this suggested treatment is not part of the new PSMAaddtion study.

They include: abiraterone (Zytiga) enzalutamide (Xtandi) apalutamide (Erleada) 25% of advanced prostate cancer deaths are due to NEPC.

Zytiga/Lupron was effective before my current ADT holiday. Is it possible that I could have become castrate resistant while on the vacation? I guess I'll know for sure once I get back on the ADT.

Anyone have an experience with hormone-sensitive first ADT treatment of Zytiga / Aberiterone rather than more typical Lupron? If so, can you share? If others haven't been treated this way but have relevant info, that would also be appreciated. Regards, Jeff

Zytiga isn’t good for either the liver or kidneys, but so far my numbers look ok after 18 months on this stuff. Any suggestions of which otc pain is better to take once per day. I am icing each day, which helps at night, but need a little boost.

Starting tomorrow Abiraterone (Zytiga) and predniSONE and on continuous LUpron.

Zytiga worked for nicely me for a few months, then not so well. I had no side effects with Zytiga. YinYin

Worked till 2022 when PSMA scan showed lymph nodes, started Zytiga in November 2022 , started with 44 Tomotherapy/IMRT in Feb 2023, My question is how long after all this radiation does he need to continue ADT he’s been on it for 4 1/2 years prior to radiation?

Xtandi is back on my formulary and zytiga- prednisone are gone now. Had me scared, trying to think of how I would have to try to manage prednisone , but all that is history now. Big relief from hefty anxiety that began back before Christmas .

To review, after 19 months on Lupron, Zytiga, prednisone, PSA increased on 1/23 to 0.253, then 0.309 on 2/21. Plarify scan showed only one active site in hip which was radiated. 4/4 PSA dropped to 0.24 which indicated the lesion was knocked out and I would be hormone sensitive and stay on Zytiga.

I need to make a decision between Erleada and zytiga for metastatic ( by psma to LN) HS prostate cancer. Which one should I choose based on efficacy. I am sure some of you are familiar with clinical trials. Thanks for your input.

Also is olparib safe with Zytiga? Any thoughts.

Should I go ahead with Docetaxel or Zytiga?