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Zytiga
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Article: FDA grants 177Lu-PSMA-617 breakthrough designation for mCRPC
The open-label phase 3 VISION trial (NCT03511664) included 831 patients (1179 initially screened) with progressive PSMA-positive mCRPC who received at least 1 novel androgen axis drug (eg, enzalutamide [Xtandi] or abiraterone acetate [
Zytiga
]) and were previously treated with 1 to 2 taxane regimens.
The open-label phase 3 VISION trial (NCT03511664) included 831 patients (1179 initially screened) with progressive PSMA-positive mCRPC who received at least 1 novel androgen axis drug (eg, enzalutamide [Xtandi] or abiraterone acetate [
Zytiga
]) and were previously treated with 1 to 2 taxane regimens.
GregHouston
in
Advanced Prostate Cancer
3 years ago
$150 Online Research Opportunity
https://www.research.net/r/Malecare Pillar Patient Advocates is seeking 10 patients who are on their 2nd line or more of 2nd generation treatments such as Xtandi,
Zytiga
, Erleada, and Nubeqa.
https://www.research.net/r/Malecare Pillar Patient Advocates is seeking 10 patients who are on their 2nd line or more of 2nd generation treatments such as Xtandi,
Zytiga
, Erleada, and Nubeqa.
Darryl
Partner
in
Advanced Prostate Cancer
3 years ago
SOC standard info on starting Xgeva without bone issues.
In Jan. 2020, after I had been on Lupron since 11/2018, my MO started me on Xgeva even though 1. I had never had a bone density scan and 2. Had no diagnosis of osteoporosis or other indicators of bone issues. In Sept. 2020 I had my first ever bone density scan and it was normal. Since then, I have read
In Jan. 2020, after I had been on Lupron since 11/2018, my MO started me on Xgeva even though 1. I had never had a bone density scan and 2. Had no diagnosis of osteoporosis or other indicators of bone issues. In Sept. 2020 I had my first ever bone density scan and it was normal. Since then, I have read
dhccpa
in
Advanced Prostate Cancer
3 years ago
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worse each treatment.....lost all my body hair and a great white beard which was my pride and joy at 53.....bone pain and chest pain.....and my taste buds go wonky for about a week....my fingernails look like a Klingon's forehead......could be worse.....PSA is lowering... chemo began after being on
Zytiga
worse each treatment.....lost all my body hair and a great white beard which was my pride and joy at 53.....bone pain and chest pain.....and my taste buds go wonky for about a week....my fingernails look like a Klingon's forehead......could be worse.....PSA is lowering... chemo began after being on
Zytiga
Mollygrace666
in
Advanced Prostate Cancer
3 years ago
Three clinical trial options after Zytiga fails
He’s 71, dx’ed nearly 3 years ago, and has already utilized Zoladex, docetaxel, and
Zytiga
and some targeted radiation. He’s had widespread mets since dx but largely feels pretty well (aside from Covid knocking him on his rear in October).
He’s 71, dx’ed nearly 3 years ago, and has already utilized Zoladex, docetaxel, and
Zytiga
and some targeted radiation. He’s had widespread mets since dx but largely feels pretty well (aside from Covid knocking him on his rear in October).
Nettie8200
in
Advanced Prostate Cancer
3 years ago
Dad 67 years old diagnosed with stage 4 Prostate Cancer, with many bone mets.
currently he is on hormones therapy and its given
Zytiga
Abiraterone. The last check up show his psa dropped to 0.16 in Mid Jan. However he experience some backpain he describe its not intense pain however like heating and ticklish pain. Also sometimes he couldn't hold his urine in time.
currently he is on hormones therapy and its given
Zytiga
Abiraterone. The last check up show his psa dropped to 0.16 in Mid Jan. However he experience some backpain he describe its not intense pain however like heating and ticklish pain. Also sometimes he couldn't hold his urine in time.
worrywaffle
in
Advanced Prostate Cancer
3 years ago
Can Abiraterone/Zytiga cause low blood sugar?
I’m diabetic and use an insulin pump. I’m on Abiraterone for about 5 months now, with hydrocortisone 10 mg per day to control Abiraterone side effects during PC treatment. Also took about 9 months Firmagon shots, but just switched to Lupron to preserve belly area for pump insulin insertion ports or continuous
I’m diabetic and use an insulin pump. I’m on Abiraterone for about 5 months now, with hydrocortisone 10 mg per day to control Abiraterone side effects during PC treatment. Also took about 9 months Firmagon shots, but just switched to Lupron to preserve belly area for pump insulin insertion ports or continuous
happycamperguy
in
Advanced Prostate Cancer
3 years ago
Dad/Heart Risk with ADT. Almost 3 years in PSA good.
Not sure if a vacation or reducing the
Zytiga
by 1 is worth it...? He looks unhealthy and both his parents died under 80 of heart and stroke. PC seems to be under control at this time. No Mets. Thoughts? Would appreciate it greatly.
Not sure if a vacation or reducing the
Zytiga
by 1 is worth it...? He looks unhealthy and both his parents died under 80 of heart and stroke. PC seems to be under control at this time. No Mets. Thoughts? Would appreciate it greatly.
DaughterOnAMission
in
Advanced Prostate Cancer
3 years ago
clinical trial olaparib and radium 223
Chemo/ADT/
zytiga
now this new trial. We are waiting for scans next month but psa jumped to 60!!!! I asked doctor about this, he said that is only one small part, scans important part and how he feels. He feels good, has had no pain at all.
Chemo/ADT/
zytiga
now this new trial. We are waiting for scans next month but psa jumped to 60!!!! I asked doctor about this, he said that is only one small part, scans important part and how he feels. He feels good, has had no pain at all.
Judymin
in
Advanced Prostate Cancer
3 years ago
Saw my Oncologist today, not good news.
The Radium 223 saw my PSA rise quickly half way through, he tried
Zytiga
+ Predisolone my PSA initially dropped to 88 in early Nov but by Dec it was up to 110 and today it's 360.
The Radium 223 saw my PSA rise quickly half way through, he tried
Zytiga
+ Predisolone my PSA initially dropped to 88 in early Nov but by Dec it was up to 110 and today it's 360.
Zetabow
in
Advanced Prostate Cancer
3 years ago
!!!3 years!!!
I was put on
Zytiga
, Eligard, Xgeva from the very start and PSA has been 0.1 ever since. I've also had Provenge treatments last June. While my fight continues the treatments have put a burden on my body and mind. The medicine has taken its toll on me.
I was put on
Zytiga
, Eligard, Xgeva from the very start and PSA has been 0.1 ever since. I've also had Provenge treatments last June. While my fight continues the treatments have put a burden on my body and mind. The medicine has taken its toll on me.
leo2634
in
Advanced Prostate Cancer
3 years ago
Can Erleada/Apalutamide and Xtandi/Enzalutimide be used subsequently or is Xtandi ineffective after Erleada stops working?
Zytiga
is probably not appropriate for me due to Coronary Artery diseases plaque buildup (30-40% with stable angina, BP is normal, blood glucose around 96). I did not do chemo after initial treatment , so 4.5 years later I am in no mans land and probably wouldn't be offered chemo by doctors.
Zytiga
is probably not appropriate for me due to Coronary Artery diseases plaque buildup (30-40% with stable angina, BP is normal, blood glucose around 96). I did not do chemo after initial treatment , so 4.5 years later I am in no mans land and probably wouldn't be offered chemo by doctors.
GeorgeGlass
in
Advanced Prostate Cancer
3 years ago
PSA raised rapidly after 2 months finishing chemo
If his doctor still has no advice on next treatment (i.e. wait for imagines of status progress), should he take
Zytiga
without a doctor’s prescription? Looking forward to receiving your advice and experience sharing. Thank you in advance, Dawn
If his doctor still has no advice on next treatment (i.e. wait for imagines of status progress), should he take
Zytiga
without a doctor’s prescription? Looking forward to receiving your advice and experience sharing. Thank you in advance, Dawn
Hidden
in
Advanced Prostate Cancer
3 years ago
PSA Surge on Zytiga
Has anyone experienced a surge in PSA after starting
Zytiga
before it started to work???? So appreciate your comments
Has anyone experienced a surge in PSA after starting
Zytiga
before it started to work???? So appreciate your comments
Hidden
in
Advanced Prostate Cancer
3 years ago
Zytiga
Sorry meant
zytiga
Sorry meant
zytiga
Tmetz
in
Advanced Prostate Cancer
3 years ago
Zytiga
My husband been on
Zytiga
about 5 months his psa was coming down very slow last psa was 13.7 it’s now 14.5 does this means the med stopped working already? Is this something I should be concerned about? Can you have small fluctuations In a psa
My husband been on
Zytiga
about 5 months his psa was coming down very slow last psa was 13.7 it’s now 14.5 does this means the med stopped working already? Is this something I should be concerned about? Can you have small fluctuations In a psa
Fight11
in
Advanced Prostate Cancer
3 years ago
Neuropathy
Now taking lupron and
zytiga
. Have developed neuropathy in feet. Anyone have this problem?
Zytiga
a cause? Thanks.
Now taking lupron and
zytiga
. Have developed neuropathy in feet. Anyone have this problem?
Zytiga
a cause? Thanks.
Altamontt
in
Prostate Cancer Network
3 years ago
Stop all meds
If you think you only have 8 months left why not stop adt and
Zytiga
? Won’t having the drugs out of your body and your testosterone back at least give you a feeling that you are more yourself? Quality of life should enter into the equation? Or am I way off on this?
If you think you only have 8 months left why not stop adt and
Zytiga
? Won’t having the drugs out of your body and your testosterone back at least give you a feeling that you are more yourself? Quality of life should enter into the equation? Or am I way off on this?
Cynthgob
in
Advanced Prostate Cancer
3 years ago
Ra223 Xofigo and Cabazataxel compared
Since diagnosis 2009 at 62yo, with inoperable Gleason 9, but with low Psa only 6, I had failed RP attempt in 2010, but has EBRT + 2 years ADT, then pause showing Pca progress so I am still on ADT, and had salvation IMRT to PG, Cosadex,
Zytiga
, 5 doses Docetaxel, all not stopping Pca progress hence move
Since diagnosis 2009 at 62yo, with inoperable Gleason 9, but with low Psa only 6, I had failed RP attempt in 2010, but has EBRT + 2 years ADT, then pause showing Pca progress so I am still on ADT, and had salvation IMRT to PG, Cosadex,
Zytiga
, 5 doses Docetaxel, all not stopping Pca progress hence move
Patrick-Turner
in
Advanced Prostate Cancer
3 years ago
Abiraterone-Firmagon ADT not working fast enough to lower PSA
I thought my decreasing PSA the past several months on Abiraterone (
Zytiga
) and Firmagon was moderately encouraging. But MO says I’m not responding well to ADT because 90% of patients like me would have PSA go down much quicker on Abiraterone and Firmagon.
I thought my decreasing PSA the past several months on Abiraterone (
Zytiga
) and Firmagon was moderately encouraging. But MO says I’m not responding well to ADT because 90% of patients like me would have PSA go down much quicker on Abiraterone and Firmagon.
happycamperguy
in
Advanced Prostate Cancer
3 years ago
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