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Xtandi
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Bipolar androgen therapy in men with metastatic castration-resistant prostate cancer after progression on enzalutamide.
And 5 out of 7 men achieved a 50% drop after
Xtandi
was resumed. Currently, BAT is a one-size-fits-all therapy. Men continue on Lupron, say, but receive monthly T injections ("testosterone cipionate 400 mg every 28 days until progression"). The T response is variable.
And 5 out of 7 men achieved a 50% drop after
Xtandi
was resumed. Currently, BAT is a one-size-fits-all therapy. Men continue on Lupron, say, but receive monthly T injections ("testosterone cipionate 400 mg every 28 days until progression"). The T response is variable.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Xtandi/Enzalutamide & Curcumin/Turmeric
More recently, Daddysdaughter: "My father is on
Xtandi
and he was told to stop taking tumeric because it decreases the effectiveness for the
Xtandi
.. he also was told to stop green tea." Rexwaterbury responded: "I am on
Xtandi
. Dr Myers also told me to stop turmeric."
More recently, Daddysdaughter: "My father is on
Xtandi
and he was told to stop taking tumeric because it decreases the effectiveness for the
Xtandi
.. he also was told to stop green tea." Rexwaterbury responded: "I am on
Xtandi
. Dr Myers also told me to stop turmeric."
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Tumeric - Good or Bad for Prostate Cancer?
Someone mentioned that tumeric might be contraindicated for anyone taking
xtandi
. Dr. Myers used to promote tumeric. Does anyone know what the contraindications are for tumeric? Does anyone know what the current thinking is about tumeric and prostate cancer?
Someone mentioned that tumeric might be contraindicated for anyone taking
xtandi
. Dr. Myers used to promote tumeric. Does anyone know what the contraindications are for tumeric? Does anyone know what the current thinking is about tumeric and prostate cancer?
cesanon
in
Advanced Prostate Cancer
6 years ago
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ASCO Genitourinary Cancers Symposium (Olaparib and Durvalumab in metastatic castrate-resistant prostate cancer (mCRPC))
While most of us do not have hereditary BRCA mutations, men who ultimately fail Zytiga/
Xtandi
might nonetheless respond to Olaparib.
While most of us do not have hereditary BRCA mutations, men who ultimately fail Zytiga/
Xtandi
might nonetheless respond to Olaparib.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Experience with Xtandi
Anyone have experience with
Xtandi
and if so, results. What therapy after
Xtandi
has anyone tried. Many thanks to all and wish all the best in fighting the Beast--be positive! Lunbo
Anyone have experience with
Xtandi
and if so, results. What therapy after
Xtandi
has anyone tried. Many thanks to all and wish all the best in fighting the Beast--be positive! Lunbo
Lunbo
in
Advanced Prostate Cancer
6 years ago
FDA Grants Priority Review to Apalutamide ...
Apalutamide may be the successor to Enzalutamide [
Xtandi
].
Apalutamide may be the successor to Enzalutamide [
Xtandi
].
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Medicare B not covering Keytruda
Since then, I have failed salvage radiation, ADT, Casodex, radiation to the left humerus (incipient fracture), Zytiga+prednisone,
Xtandi
, and full replacement of the left shoulder.
Since then, I have failed salvage radiation, ADT, Casodex, radiation to the left humerus (incipient fracture), Zytiga+prednisone,
Xtandi
, and full replacement of the left shoulder.
gvweller
in
Advanced Prostate Cancer
6 years ago
Xtandi and Severe abdominal cramps.
Anyone experience severe abdominal cramps with
Xtandi
? If so what are you doing to control cramps/pain. There are many reports of pain and abdominal cramps but what is causing it and what will help with it. No narcotic/opioid for pain. He is currently on no pain medications. Only takes Advil.
Anyone experience severe abdominal cramps with
Xtandi
? If so what are you doing to control cramps/pain. There are many reports of pain and abdominal cramps but what is causing it and what will help with it. No narcotic/opioid for pain. He is currently on no pain medications. Only takes Advil.
Daddysdaughter
in
Advanced Prostate Cancer
6 years ago
Why Resistance To Xtandi and Zytiga Develops
Looks like combination therapy is the way to go to delay resistance Gus http://www.sciencedirect.com/science/article/pii/S2214388215000247
Looks like combination therapy is the way to go to delay resistance Gus http://www.sciencedirect.com/science/article/pii/S2214388215000247
gusgold
in
Advanced Prostate Cancer
6 years ago
The War on Cancer, & Stem-like Cancer Cells.
The big success stories of recent years - Zytiga &
Xtandi
- follow in the Huggins tradition by targeting the androgen receptor [AR], either directly (as with Casodex, & now
Xtandi
) or by starving AR of hormones (as with castration, DES, Lupron, & now Zytiga). Alas, PCa progenitor cells lack AR.
The big success stories of recent years - Zytiga &
Xtandi
- follow in the Huggins tradition by targeting the androgen receptor [AR], either directly (as with Casodex, & now
Xtandi
) or by starving AR of hormones (as with castration, DES, Lupron, & now Zytiga). Alas, PCa progenitor cells lack AR.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Xtandi (Enzalutamide) & Drug-Drug Interaction.
Worth asking if dosages will be diluted by
Xtandi
. The Pharma attitude to liver enzymes, rather than inhibiting them, is to use ten times as much drug, say, on the basis that the liver will destroy 90%. But in the case of
Xtandi
, there seems to be a case for inhibiting excess production of CYP3A4.
Worth asking if dosages will be diluted by
Xtandi
. The Pharma attitude to liver enzymes, rather than inhibiting them, is to use ten times as much drug, say, on the basis that the liver will destroy 90%. But in the case of
Xtandi
, there seems to be a case for inhibiting excess production of CYP3A4.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Xtandi Lower Dose Work?
I have a question for those of you that had been on
Xtandi
and had significant side effects. My father began
Xtandi
and after the 3rd week we saw significant mood change, depression and forgetfulness. The MO recommend we lower the dose to 3 pills a day. Since then my father is back!
I have a question for those of you that had been on
Xtandi
and had significant side effects. My father began
Xtandi
and after the 3rd week we saw significant mood change, depression and forgetfulness. The MO recommend we lower the dose to 3 pills a day. Since then my father is back!
Daddysdaughter
in
Advanced Prostate Cancer
6 years ago
Finally, Real Promise' for Prostate Cancers With No Therapy20+-Month Improvement in Metastasis-Free Survival
The PROSPER trial employed the earlier-generation enzalutamide (
Xtandi
, Astellas/Pfizer), which is already approved for men who have metastatic prostate cancer.
The PROSPER trial employed the earlier-generation enzalutamide (
Xtandi
, Astellas/Pfizer), which is already approved for men who have metastatic prostate cancer.
Hidden
in
Advanced Prostate Cancer
6 years ago
How to Find a good pain management and/or Quality of life specialist for an advanced metastic prostate cancer patient
I believe it is the result of the side effects from the pain medication (50mcg/hr fentanyl patches and 4mg Hydromorphone tablets every 4 hours as needed) and
Xtandi
(4 40mg capsules every 4 hours as needed) which I started August 15.
I believe it is the result of the side effects from the pain medication (50mcg/hr fentanyl patches and 4mg Hydromorphone tablets every 4 hours as needed) and
Xtandi
(4 40mg capsules every 4 hours as needed) which I started August 15.
chascri
in
Advanced Prostate Cancer
6 years ago
New Guy Info
I will start taking the
Xtandi
in a few days and thought I might be able to relate my experience with it here to possibly help others. I am 69 years old and in good health other than having a incurable disease.
I will start taking the
Xtandi
in a few days and thought I might be able to relate my experience with it here to possibly help others. I am 69 years old and in good health other than having a incurable disease.
steveebear
in
Advanced Prostate Cancer
6 years ago
Xtandi after Zytiga
Has anyone had any luck with
Xtandi
after Zytiga?
Has anyone had any luck with
Xtandi
after Zytiga?
wrando
in
Advanced Prostate Cancer
6 years ago
Xtandi dosage
Started on
xtandi
10 weeks ago and PSA has reduced from 30 to 5 . I have been taking the tablets one 4 times a day but now I realise from other posts here that I should have been taking the 160 mgs all at once.
Started on
xtandi
10 weeks ago and PSA has reduced from 30 to 5 . I have been taking the tablets one 4 times a day but now I realise from other posts here that I should have been taking the 160 mgs all at once.
Hidden
in
Advanced Prostate Cancer
7 years ago
CVS in talks to buy Aetna
Now, it makes sense why I was denied
Xtandi
. And now, JoelT's post from last year, about CVS, is coming to fruition. This is a sad state of affairs, in my opinion. Joe
Now, it makes sense why I was denied
Xtandi
. And now, JoelT's post from last year, about CVS, is coming to fruition. This is a sad state of affairs, in my opinion. Joe
Hidden
in
Advanced Prostate Cancer
7 years ago
Abi to Enzi no cross resistance yet
Changed to
xtandi
. and after four months went to 5.64 . Hope Provenge is doing it’s thing in the microenvironment. Alkaline phosphatase down 60. No pain in almost 8 years.
Changed to
xtandi
. and after four months went to 5.64 . Hope Provenge is doing it’s thing in the microenvironment. Alkaline phosphatase down 60. No pain in almost 8 years.
Drcrunch
in
Advanced Prostate Cancer
7 years ago
Dx 3/2017 PSA 363 with bone mets
The pain is back in his hips - side effects of
Xtandi
or mets?? Don't know. He will have a PET scan soon. Dr is getting that scheduled now. Also getting Procrit shots every week Xgeva every 4 weeks and Zoladex every 12 weeks.
The pain is back in his hips - side effects of
Xtandi
or mets?? Don't know. He will have a PET scan soon. Dr is getting that scheduled now. Also getting Procrit shots every week Xgeva every 4 weeks and Zoladex every 12 weeks.
CaregiverWife
in
Advanced Prostate Cancer
7 years ago
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