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Xtandi
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Any treatments left?
He has been on abiraterone,
Xtandi
twice, zytiga, Docetaxel, radium-223, BAT and now he is about to get his 8th treatment of Jevtana. He is 77 years old and is tolerating the Jevtana pretty well. His recent bloodwork shows his PSA is a little over 1000 and his phosphates are just over 300.
He has been on abiraterone,
Xtandi
twice, zytiga, Docetaxel, radium-223, BAT and now he is about to get his 8th treatment of Jevtana. He is 77 years old and is tolerating the Jevtana pretty well. His recent bloodwork shows his PSA is a little over 1000 and his phosphates are just over 300.
Amandaslp78
in
Advanced Prostate Cancer
4 years ago
Clinical Trial Niraparib or XOFIGO
Started on Firmagon/
Xtandi
ADT in 08/2019 with the Firmagon being changed to Lupron shortly after. He was treated with a course of external beam radiation therapy 79.2 Gy in 44 fractions to the prostate, seminal vesicles, and pelvic lymph nodes, completed on 03/30/2020.
Started on Firmagon/
Xtandi
ADT in 08/2019 with the Firmagon being changed to Lupron shortly after. He was treated with a course of external beam radiation therapy 79.2 Gy in 44 fractions to the prostate, seminal vesicles, and pelvic lymph nodes, completed on 03/30/2020.
Doradart
in
Advanced Prostate Cancer
3 years ago
Is Erleada as effective as Xtandi in slowing the growth of Cancer Cells? If so, how can you lesson the terrible side effects?
The fatigue is terrible followed very closely with depression. Anyone know how to reduce these side effects
The fatigue is terrible followed very closely with depression. Anyone know how to reduce these side effects
jpmeljps
in
Advanced Prostate Cancer
4 years ago
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Resetting the Bar of Castration Resistance - Understanding Androgen Dynamics in Therapy Resistance and Treatment Choice in PCa
XTANDI
® (enzalutamide) [prescribing information]: Astellas Pharma Inc.; 2012. 107. Ning YM, Brave M, Maher VE, et al. U.S. Food and Drug Administration Approval Summary: Enzalutamide for the Treatment of Patients With Chemotherapy-Naïve Metastatic Castration-Resistant Prostate Cancer.
XTANDI
® (enzalutamide) [prescribing information]: Astellas Pharma Inc.; 2012. 107. Ning YM, Brave M, Maher VE, et al. U.S. Food and Drug Administration Approval Summary: Enzalutamide for the Treatment of Patients With Chemotherapy-Naïve Metastatic Castration-Resistant Prostate Cancer.
pjoshea13
in
Advanced Prostate Cancer
3 years ago
clinical trial UK
PSA now rising after 10 months on
Xtandi
. Oncologist has suggested he is a good candidate for a clinical trial where his original samples are sent to USA for profiling. Unfortunately I was not able to be at this appointment and he did not ask questions...
PSA now rising after 10 months on
Xtandi
. Oncologist has suggested he is a good candidate for a clinical trial where his original samples are sent to USA for profiling. Unfortunately I was not able to be at this appointment and he did not ask questions...
Jojoberries
in
Advanced Prostate Cancer
4 years ago
Lu-177 continue or not ?
Radiographic scans been made: PET-PSMA CT two weeks before first Lu-177 Spect the day after each infusion PET-PSMA CT two weeks after third Lu-177 I am on
Xtandi
, started just two weeks before first infusion, and since then.
Radiographic scans been made: PET-PSMA CT two weeks before first Lu-177 Spect the day after each infusion PET-PSMA CT two weeks after third Lu-177 I am on
Xtandi
, started just two weeks before first infusion, and since then.
bjornbar
in
Advanced Prostate Cancer
4 years ago
Lynparza & BRCA1, BRCA2 or ATM-mutated cancer Survival.
"Men with BRCA1, BRCA2 or ATM-mutated cancers lived 19.1 months versus 14.7 months for those on Zytiga or
Xtandi
—and that was despite two-thirds of patients in the control arm crossing over to receive Lynparza after their disease worsened.
"Men with BRCA1, BRCA2 or ATM-mutated cancers lived 19.1 months versus 14.7 months for those on Zytiga or
Xtandi
—and that was despite two-thirds of patients in the control arm crossing over to receive Lynparza after their disease worsened.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
I met my new Doc here in America
Interestingly I'm taking generic
Xtandi
. My PSA started to slowly go back up and my Thailand doctor said to double up on my prednisone to see if it helps.
Interestingly I'm taking generic
Xtandi
. My PSA started to slowly go back up and my Thailand doctor said to double up on my prednisone to see if it helps.
FinalBossMatt
in
Advanced Prostate Cancer
4 years ago
Advice and Opinions would be great.
* Enzalutamide (
Xtandi
) * Ketoconazole * High dose Testosterone to shock the PCa cells.
* Enzalutamide (
Xtandi
) * Ketoconazole * High dose Testosterone to shock the PCa cells.
taylor123
in
Advanced Prostate Cancer
3 years ago
Next steps with high PSA during Jevtana
My doc and I agreed to take
Xtandi
again for 2 months or so to see if it can attack the PSA again, then to consider Xofigo radiation to attack the bones. Do you folks have any suggestions?
My doc and I agreed to take
Xtandi
again for 2 months or so to see if it can attack the PSA again, then to consider Xofigo radiation to attack the bones. Do you folks have any suggestions?
tomtom9148
in
Advanced Prostate Cancer
4 years ago
Prostar trial over
Done zytiga and now
Xtandi
in the Prostar trial. The trial will not be going to phase 3. At least It helped me for almost half a year
Done zytiga and now
Xtandi
in the Prostar trial. The trial will not be going to phase 3. At least It helped me for almost half a year
Peterd110
in
Advanced Prostate Cancer
4 years ago
Xtandi to Zytiga
I just finished 3 years of treatment with
Xtandi
(enzalutamide) with my psa going from 6.80 (07/19/17) and dropping to a low of 0.23 (03/15/18) . My psa then began a steady climb to 3.19 (08/02/19) and continued to 9.32 (07/16/20.
I just finished 3 years of treatment with
Xtandi
(enzalutamide) with my psa going from 6.80 (07/19/17) and dropping to a low of 0.23 (03/15/18) . My psa then began a steady climb to 3.19 (08/02/19) and continued to 9.32 (07/16/20.
docbulldog
in
Advanced Prostate Cancer
4 years ago
ADT not working?
At what point do I switch to additional therapy (Casodex, Zytiga,
Xtandi
, etc.)? And which would be the most appropriate next step of the options?
At what point do I switch to additional therapy (Casodex, Zytiga,
Xtandi
, etc.)? And which would be the most appropriate next step of the options?
CharlieBC
in
Advanced Prostate Cancer
4 years ago
RADIUM... My dad is extremely exhausted and weak since started RADIUM 223 a week ago . Xtandi started 3 weeks ago. Please Respond.
Lupron ( has been on long)
Xtandi
Exgeeva Radium -223 (xofigo) Ty guys for always making me laugh, for teaching me, for being brave, honest, and loving. I am grateful. A loving and worried daughter, Erica
Lupron ( has been on long)
Xtandi
Exgeeva Radium -223 (xofigo) Ty guys for always making me laugh, for teaching me, for being brave, honest, and loving. I am grateful. A loving and worried daughter, Erica
Daddyishealing
in
Advanced Prostate Cancer
4 years ago
Is ADT necessary when you take Zytiga?
It did not evaluate stopping ADT with any other second-generation hormone manipulations like
Xtandi
or Darolutamide. "CAUTION "Under no circumstances should you stop your primary ADT treatment without a careful conversation and your medical oncologist's agreement.
It did not evaluate stopping ADT with any other second-generation hormone manipulations like
Xtandi
or Darolutamide. "CAUTION "Under no circumstances should you stop your primary ADT treatment without a careful conversation and your medical oncologist's agreement.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Our Saga so far...and an observation about quality of care
Five months of Abiraterone and
Xtandi
have left him almost completely drained of energy. On the old ADT he kept very active, working outside every day, hiking, etc. but now he can't do much of anything.
Five months of Abiraterone and
Xtandi
have left him almost completely drained of energy. On the old ADT he kept very active, working outside every day, hiking, etc. but now he can't do much of anything.
WildRose6
in
Advanced Prostate Cancer
4 years ago
First post
Now I have been accepted into a international clinical trial of
Xtandi
tablets 140mg every day and 3 weekly infusion of either Keytrunda or placebo so far 2 cycles with some usual side effects My PSA has now reduced to 3 which my oncologist is happy with I'm being highly monitored with blood tests and
Now I have been accepted into a international clinical trial of
Xtandi
tablets 140mg every day and 3 weekly infusion of either Keytrunda or placebo so far 2 cycles with some usual side effects My PSA has now reduced to 3 which my oncologist is happy with I'm being highly monitored with blood tests and
Sebara
in
Advanced Prostate Cancer
4 years ago
Intolerable side effects from Xtandi
He was put on
Xtandi
4x40mg tBlets per day. For 6 weeks all was fine, but the side effects have become ever more difficult.
He was put on
Xtandi
4x40mg tBlets per day. For 6 weeks all was fine, but the side effects have become ever more difficult.
Grasscutters
in
Advanced Prostate Cancer
4 years ago
Castrate resistant
How long with being castrate resistant with Mets has Zytiga or
Xtandi
kept your cancer at bay? Our Oncologist said two yrs the most. Have any of you gone longer than that
How long with being castrate resistant with Mets has Zytiga or
Xtandi
kept your cancer at bay? Our Oncologist said two yrs the most. Have any of you gone longer than that
Fight11
in
Advanced Prostate Cancer
4 years ago
Success with SBRT
Have been on
Xtandi
but did not work now on zytiga even though told chances it will work are slim. Radiologists feels this will help with pain and kill some of the cancer cells. Next step is possibly radium once they see if the zytiga works or not. Appreciate any input.
Have been on
Xtandi
but did not work now on zytiga even though told chances it will work are slim. Radiologists feels this will help with pain and kill some of the cancer cells. Next step is possibly radium once they see if the zytiga works or not. Appreciate any input.
Scootman
in
Advanced Prostate Cancer
4 years ago
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