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Ropeginterferon alfa-2b
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Recently diagnosed with Primary Myelofibrosis
I was immediately asked if I wanted to join a new research study to evaluate the tolerability, safety and activity of fedratinib combined with
ropeginterferon
alfa
-
2b
. I signed up immediately thinking at least I should get monitored very closely.
I was immediately asked if I wanted to join a new research study to evaluate the tolerability, safety and activity of fedratinib combined with
ropeginterferon
alfa
-
2b
. I signed up immediately thinking at least I should get monitored very closely.
Flyingsteamer
in
MPN Voice
2 years ago
Ropeg 6 Year Allele Data (apparently) Revealed
"At six years, 20.7% of patients in the
ropeginterferon
alfa
-
2b
group (n=19) achieved a JAK2V617F allele burden of less than 1%" But it does read nicely hence its easily found result.
"At six years, 20.7% of patients in the
ropeginterferon
alfa
-
2b
group (n=19) achieved a JAK2V617F allele burden of less than 1%" But it does read nicely hence its easily found result.
EPguy
in
MPN Voice
2 years ago
What and Why is IFN Pegylation?
https://www.onclive.com/view/
ropeginterferon
-
alfa
-
2b
-proves-to-be-efficacious-safe-in-japanese-patients-with-polycythemia-vera
https://www.onclive.com/view/
ropeginterferon
-
alfa
-
2b
-proves-to-be-efficacious-safe-in-japanese-patients-with-polycythemia-vera
EPguy
in
MPN Voice
2 years ago
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Keeping Interferon refrigerated
Hi, I've recently started taking Peginterferon alfa-2a, and I keep it in my fridge because that's what the instructions say. I'm going to visit my girlfriend in Scotland a week tomorrow. My journey is going to take two days, so I'll leave home on Saturday morning, stay in a hotel halfway on Saturday
Hi, I've recently started taking Peginterferon alfa-2a, and I keep it in my fridge because that's what the instructions say. I'm going to visit my girlfriend in Scotland a week tomorrow. My journey is going to take two days, so I'll leave home on Saturday morning, stay in a hotel halfway on Saturday
little_oblivion
in
MPN Voice
2 years ago
Christmas Chuckle
Holiday time is for feasting; We look forward to each treat. The tables are full of our favorite foods; We’ve got lots of good things to eat. We scarf marshmallowed sweet potatoes; There’s cider and eggnog to slurp. There’s so much going down at once, Who can help an occasional burp? Here’
Holiday time is for feasting; We look forward to each treat. The tables are full of our favorite foods; We’ve got lots of good things to eat. We scarf marshmallowed sweet potatoes; There’s cider and eggnog to slurp. There’s so much going down at once, Who can help an occasional burp? Here’
Paul_and_Sue_Wood
in
Multiple System Atrophy Trust
2 years ago
A bit of drama on Besremi
Discontinuation of
ropeginterferon
alfa
-
2b
should be considered in patients who develop new or worsening eye disorders>>
Discontinuation of
ropeginterferon
alfa
-
2b
should be considered in patients who develop new or worsening eye disorders>>
EPguy
in
MPN Voice
2 years ago
Defining INF effectiveness
The study even went to 700. https://mpn-hub.com/medical-information/5-year-results-from-the-proud-pv-and-continuation-pv-studies <<The median dose of
ropeginterferon
alfa
-
2b
per treatment cycle (4 weeks) in the fifth year was 499 μg, compared with > 700 μg in Years 1 and 2.>> These are huge numbers for
The study even went to 700. https://mpn-hub.com/medical-information/5-year-results-from-the-proud-pv-and-continuation-pv-studies <<The median dose of
ropeginterferon
alfa
-
2b
per treatment cycle (4 weeks) in the fifth year was 499 μg, compared with > 700 μg in Years 1 and 2.>> These are huge numbers for
EPguy
in
MPN Voice
2 years ago
Peg injections - two in one day
Hi all, I’m on peginterferon Alfa-2a for ET and a few weeks ago my dose was increased to 180mg. The hospital pharmacy deliver my medication and I can only assume they’ve ran out of 180mg syringes as I’ve been sent about 8 boxes of 90mg pre filled syringes meaning I’m expected to do 2 injections after
Hi all, I’m on peginterferon Alfa-2a for ET and a few weeks ago my dose was increased to 180mg. The hospital pharmacy deliver my medication and I can only assume they’ve ran out of 180mg syringes as I’ve been sent about 8 boxes of 90mg pre filled syringes meaning I’m expected to do 2 injections after
FashionLover
in
MPN Voice
2 years ago
FDA Approves Ropeginterferon Alfa-2b-njft for Polycythemia Vera
https://www.onclive.com/view/fda-approves-
ropeginterferon
-
alfa
-
2b
-njft-for-polycythemia-vera
https://www.onclive.com/view/fda-approves-
ropeginterferon
-
alfa
-
2b
-njft-for-polycythemia-vera
JT_Marlin
in
MPN Voice
3 years ago
Effective INF Dose Part 2, more considerations, research, and Dr vs patient wishes
. --- 5 year follow Up ContiPV (Besremi trial) https://www.nature.com/articles/s41375-022-01528-x#MOESM1 and Supplement: https://static-content.springer.com/esm/art%3A10.1038%2Fs41375-022-01528-x/MediaObjects/41375_2022_1528_MOESM1_ESM.docx << in patients treated with
ropeginterferon
alfa
-
2b
for
. --- 5 year follow Up ContiPV (Besremi trial) https://www.nature.com/articles/s41375-022-01528-x#MOESM1 and Supplement: https://static-content.springer.com/esm/art%3A10.1038%2Fs41375-022-01528-x/MediaObjects/41375_2022_1528_MOESM1_ESM.docx << in patients treated with
ropeginterferon
alfa
-
2b
for
EPguy
in
MPN Voice
2 years ago
Besremi Progress in US
<<BESREMi® (
ropeginterferon
alfa
-
2b
-njft) Injection Is Available From Onco360!>> https://www.onco360.com/oncology-medications/limited-distribution-medications/besremiropeginterferon-alfa-2b-njft-injection/
<<BESREMi® (
ropeginterferon
alfa
-
2b
-njft) Injection Is Available From Onco360!>> https://www.onco360.com/oncology-medications/limited-distribution-medications/besremiropeginterferon-alfa-2b-njft-injection/
EPguy
in
MPN Voice
3 years ago
US Ropeg approval!
-FDA-Approves-BESREMi%C2%AE-
ropeginterferon
-
alfa
-
2b
-njft-as-the-Only-Interferon-for-Adults-With-Polycythemia-Vera It has FDA black box warning for serious possible side effects.
-FDA-Approves-BESREMi%C2%AE-
ropeginterferon
-
alfa
-
2b
-njft-as-the-Only-Interferon-for-Adults-With-Polycythemia-Vera It has FDA black box warning for serious possible side effects.
EPguy
in
MPN Voice
3 years ago
Cost of Interferon Alfa 2a
Does Interferon Alfa 2a (Pegasus) cost $1000 for 180mcg/ml ?? Without insurance?
Does Interferon Alfa 2a (Pegasus) cost $1000 for 180mcg/ml ?? Without insurance?
MrThara
in
MPN Voice
2 years ago
Clinical Experience with Ropeginterferon Alfa-2b in the Off-Label Use for the Treatment of COVID-19 Patients in Taiwan(Besremi)
In addition to the indications for PV and ET, Besremi expects the phase 3 clinical success of the new coronavirus. Judging from the current coronavirus pandemic in about a few years, This is good news for MPN patients. Usually, patients will have the problem of decreased immunity during treatment, and
In addition to the indications for PV and ET, Besremi expects the phase 3 clinical success of the new coronavirus. Judging from the current coronavirus pandemic in about a few years, This is good news for MPN patients. Usually, patients will have the problem of decreased immunity during treatment, and
andrew_huang
in
MPN Voice
3 years ago
Besremi versus Pegasys
.>> https://www.cancer.gov/publications/dictionaries/cancer-drug/def/
ropeginterferon
-
alfa
-
2b
Pegasys has multiple possible pegylation sites. The maker of Besremi states that the single site is a reason Besremi acts longer, more evenly over time, with a more mild profile vs earlier PEGs.
.>> https://www.cancer.gov/publications/dictionaries/cancer-drug/def/
ropeginterferon
-
alfa
-
2b
Pegasys has multiple possible pegylation sites. The maker of Besremi states that the single site is a reason Besremi acts longer, more evenly over time, with a more mild profile vs earlier PEGs.
EPguy
in
MPN Voice
3 years ago
TOWARDS A POTENTIAL OPERATIONAL CURE IN PATIENTS WITH POLYCYTHAEMIA VERA?
Conclusion A sizable proportion of patients with PV achieved operational cure after 5 years’
ropeginterferon
alfa
-
2b
treatment.
Conclusion A sizable proportion of patients with PV achieved operational cure after 5 years’
ropeginterferon
alfa
-
2b
treatment.
Manouche
in
MPN Voice
3 years ago
U.S. FDA Accepts PharmaEssentia’s BLA Resubmission for Besremi
-FDA-Accepts-PharmaEssentia%E2%80%99s-BLA-Resubmission-for-
ropeginterferon
-
alfa
-
2b
-njft-for-the-Treatment-of-Polycythemia-Vera-PV
-FDA-Accepts-PharmaEssentia%E2%80%99s-BLA-Resubmission-for-
ropeginterferon
-
alfa
-
2b
-njft-for-the-Treatment-of-Polycythemia-Vera-PV
Manouche
in
MPN Voice
3 years ago
PharmaEssentia Resubmits Application to the U.S. FDA For Ropeginterferon alfa-2b-njft to Treat Polycythemia Vera (PV)
Also noted were COVID-related restrictions that delayed the required pre-approval inspection of the company’s manufacturing facility in Taiwan. » https://stocksnewsfeed.com/businesswire/pharmaessentia-resubmits-application-to-the-u-s-fda-for-
ropeginterferon
-
alfa
-
2b
-njft-to-treat-polycythemia-vera-pv
Also noted were COVID-related restrictions that delayed the required pre-approval inspection of the company’s manufacturing facility in Taiwan. » https://stocksnewsfeed.com/businesswire/pharmaessentia-resubmits-application-to-the-u-s-fda-for-
ropeginterferon
-
alfa
-
2b
-njft-to-treat-polycythemia-vera-pv
Manouche
in
MPN Voice
3 years ago
FDA Issues Complete Response Letter for Ropeginterferon Alfa-2b for Polycythemia Vera
« The FDA has issued a complete response letter regarding the biologics license application for
ropeginterferon
alfa
-
2b
-njft for the treatment of patients with polycythemia vera » https://www.onclive.com/view/fda-issues-complete-response-letter-for-
ropeginterferon
-
alfa
-
2b
-for-polycythemia-vera
« The FDA has issued a complete response letter regarding the biologics license application for
ropeginterferon
alfa
-
2b
-njft for the treatment of patients with polycythemia vera » https://www.onclive.com/view/fda-issues-complete-response-letter-for-
ropeginterferon
-
alfa
-
2b
-for-polycythemia-vera
Manouche
in
MPN Voice
3 years ago
FDA Issues Complete Response Letter for Ropeginterferon Alfa-2b for Polycythemia Vera
“We remain fully committed to introducing
ropeginterferon
alfa
-
2b
-njft to the US polycythemia vera community.”
“We remain fully committed to introducing
ropeginterferon
alfa
-
2b
-njft to the US polycythemia vera community.”
JT_Marlin
in
MPN Voice
3 years ago
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