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Currently in phase 1 but promising: Bispecific Antibody Programs and IL-12 Cytokine, XmAb662
early results are positive on solid tumors, including prostate https://www.pharmaceutical-technology.com/data-insights/xmab-662-xencor-metastatic-castration-resistant-prostate-cancer-mcrpc-likelihood-of-approval-2/ Thanks mhamle01 !!
early results are positive on solid tumors, including prostate https://www.pharmaceutical-technology.com/data-insights/xmab-662-xencor-metastatic-castration-resistant-prostate-cancer-mcrpc-likelihood-of-approval-2/ Thanks mhamle01 !!
Maxone73
in
Advanced Prostate Cancer
5 months ago
PSA Rising and MRI Negative
A recent PET Scan showed cancer cells in the
Prostate
bed, but the MRI didn't pick-up any
disease
. The Oncologist is checking labs, and will start my husband on HT.Question for the group. Why would PET scan pick-up cancer cells, and not the MRI? TY The Inquisitive One
A recent PET Scan showed cancer cells in the
Prostate
bed, but the MRI didn't pick-up any
disease
. The Oncologist is checking labs, and will start my husband on HT.Question for the group. Why would PET scan pick-up cancer cells, and not the MRI? TY The Inquisitive One
Inquisitive_one
in
Advanced Prostate Cancer
4 months ago
PSMA PET Looks Good But PSA Rising
PSMA tracer avid
prostate
gland
disease
, probably diminished in extent scintigraphically. 2. No PSMA tracer avid metastases evident elsewhere. Additional findings as above FINAL REPORT
PSMA tracer avid
prostate
gland
disease
, probably diminished in extent scintigraphically. 2. No PSMA tracer avid metastases evident elsewhere. Additional findings as above FINAL REPORT
FaithOverFear104
in
Advanced Prostate Cancer
3 months ago
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Dutasteride (5-ARI) extends time to disease progression in Low-Risk men on Active Surveillance, compared to Placebo
This study by Finelli et al. (2010) looks at the effect of Dutasteride (5-ARI) on the rate of
prostate
cancer
disease
progression in Low-Risk men on Active Surveillance.
This study by Finelli et al. (2010) looks at the effect of Dutasteride (5-ARI) on the rate of
prostate
cancer
disease
progression in Low-Risk men on Active Surveillance.
janebob99
in
Prostate Cancer Network
24 days ago
Can Nubeqa (Darolutamide) be used instead of normal ADT drugs for localized PCa?
Hi all. Australia has just given the green light to lower the cost of this so-called wonder drug from a staggering $40K (AUD) to a low $30. It seems that this drug has fewer side effects than the usual ADT drugs and from what I can gather does a pretty good job of preventing the growth and spread
Hi all. Australia has just given the green light to lower the cost of this so-called wonder drug from a staggering $40K (AUD) to a low $30. It seems that this drug has fewer side effects than the usual ADT drugs and from what I can gather does a pretty good job of preventing the growth and spread
Mike58
in
Advanced Prostate Cancer
6 months ago
Interesting paper/discovery - two types of PCa
Found by AI: https://medicalxpress.com/news/2024-02-ai-reveals-prostate-cancer-disease.html [i]Artificial Intelligence has helped scientists reveal a new form of aggressive
prostate
cancer that could revolutionize how the
disease
is diagnosed and treated in the future.
Found by AI: https://medicalxpress.com/news/2024-02-ai-reveals-prostate-cancer-disease.html [i]Artificial Intelligence has helped scientists reveal a new form of aggressive
prostate
cancer that could revolutionize how the
disease
is diagnosed and treated in the future.
Don_1213
in
Prostate Cancer Network
2 months ago
Great Medical Oncologist in Seattle?
Hi everyone - After a removed lymph node was found to have cancer in it after my prostatectomy, I’ve migrated myself over to this Advanced Prostate Cancer group. I keep joining these new clubs. I must be popular. Does anyone know of a great Medical Oncologist specializing in prostate cancer in the
Hi everyone - After a removed lymph node was found to have cancer in it after my prostatectomy, I’ve migrated myself over to this Advanced Prostate Cancer group. I keep joining these new clubs. I must be popular. Does anyone know of a great Medical Oncologist specializing in prostate cancer in the
MakeItRainbows
in
Advanced Prostate Cancer
6 months ago
QoL Please, always
Friends, please remember to include the letters "QoL" in front of your title whenever you post about quality of life things that are not directly related to prostate cancer
Friends, please remember to include the letters "QoL" in front of your title whenever you post about quality of life things that are not directly related to prostate cancer
Darryl
Partner
in
Advanced Prostate Cancer
7 months ago
Two-fer
PD is bad and
prostate
disease
is bad. But both together is a two-fer. Peeing earlier today I aimed at the pot but shortly felt something on my ankle and realized I was peeing two streams. One in the pot and one off to the side, outside the pot and onto my ankle.
PD is bad and
prostate
disease
is bad. But both together is a two-fer. Peeing earlier today I aimed at the pot but shortly felt something on my ankle and realized I was peeing two streams. One in the pot and one off to the side, outside the pot and onto my ankle.
kaypeeoh
in
Cure Parkinson's
10 months ago
secondary cancer
Has anyone been diagnosed with bone marrow cancer as well as prostate cancer? My husband is getting ready to have a bone marrow biopsy to see if that is what is going on. I have read that chemo and radiation can lead to bone cancers😖
Has anyone been diagnosed with bone marrow cancer as well as prostate cancer? My husband is getting ready to have a bone marrow biopsy to see if that is what is going on. I have read that chemo and radiation can lead to bone cancers😖
Peloton
in
Advanced Prostate Cancer
7 months ago
Immunotherapy could surprise us: Columbia study about mCRPC patients
"Immunotherapy has been disappointing as a prostate cancer treatment, but a new Columbia study suggests that the powerful treatments have potential when the
disease
starts to spread." https://www.cuimc.columbia.edu/news/metastatic-
prostate
-cancer-immunotherapy-may-have-unexpected-potential
"Immunotherapy has been disappointing as a prostate cancer treatment, but a new Columbia study suggests that the powerful treatments have potential when the
disease
starts to spread." https://www.cuimc.columbia.edu/news/metastatic-
prostate
-cancer-immunotherapy-may-have-unexpected-potential
Maxone73
in
Advanced Prostate Cancer
5 months ago
How can I support my brother?
My brother has advanced prostate cancer and has had surgery. New tests show it has metastasised in his hip. I want to be able to support him but also don't want to say the wrong thing or add to the stress he is already feeling. I would appreciate ANY advice ~ thank you so much.
My brother has advanced prostate cancer and has had surgery. New tests show it has metastasised in his hip. I want to be able to support him but also don't want to say the wrong thing or add to the stress he is already feeling. I would appreciate ANY advice ~ thank you so much.
wavedancers
in
Advanced Prostate Cancer
7 months ago
Coincidentally ...
Although the authors recognize that CVD risk is higher in men with PCa ("[i]Cardiovascular
disease
(CVD) incidence is higher in men with
prostate
cancer (PC) than without.[/i]"), they do not hypothesise as to what the common thread might be. { - e.g. insulin resistance.
Although the authors recognize that CVD risk is higher in men with PCa ("[i]Cardiovascular
disease
(CVD) incidence is higher in men with
prostate
cancer (PC) than without.[/i]"), they do not hypothesise as to what the common thread might be. { - e.g. insulin resistance.
pca2004
in
Fight Prostate Cancer
8 months ago
Gasoline?
A question for anyone who has found an answer... From 2018, when diagnosed, I have been told by doctors, urologists and oncologists that; "Testosterone, in prostate cancer, is like gasoline on a fire!" When I first heard this it seemed dubious since what I "knew" about PCa was that young men with
A question for anyone who has found an answer... From 2018, when diagnosed, I have been told by doctors, urologists and oncologists that; "Testosterone, in prostate cancer, is like gasoline on a fire!" When I first heard this it seemed dubious since what I "knew" about PCa was that young men with
VoxHope
in
Advanced Prostate Cancer
16 hours ago
XTANDI(Enzalutamide) Granted European Commission Approval for Use in Additional Recurrent Early Prostate Cancer Treatment Setting
...well...the title speaks for itself XTANDI is now the first and only novel hormone therapy available for the treatment of high-risk biochemical recurrent non-metastatic hormone-sensitive prostate cancer in the European Union (EU) XTANDI can be given alone or in combination with androgen deprivation
...well...the title speaks for itself XTANDI is now the first and only novel hormone therapy available for the treatment of high-risk biochemical recurrent non-metastatic hormone-sensitive prostate cancer in the European Union (EU) XTANDI can be given alone or in combination with androgen deprivation
Maxone73
in
Advanced Prostate Cancer
7 days ago
Ketogenic diet alters the epigenetic and immune landscape of prostate cancer to overcome resistance to immune checkpoint blockade therapy.
Overall, this strikes me as too hypothetical for us to apply, but what do I know? "Overall, these findings illuminate a potential clinical path of using HDACi and optimized KD regimens to enhance ICB therapy for PCa." HDACi = histone deacetylase inhibitor [To date, four HDAC inhibitors, Vorinostat
Overall, this strikes me as too hypothetical for us to apply, but what do I know? "Overall, these findings illuminate a potential clinical path of using HDACi and optimized KD regimens to enhance ICB therapy for PCa." HDACi = histone deacetylase inhibitor [To date, four HDAC inhibitors, Vorinostat
cigafred
in
Fight Prostate Cancer
9 days ago
Gamma Delta CAR T for Bone Metastatic Prostate Cancer: first trial at Moffit
Another trial of something that targets bone metastasis, and works even better if you are under zolendronate . "Most importantly, gamma delta T cells are unique in that they are most efficient when combined with a drug (zoledronate) that is commonly used to protect the bone in patients with bone metastatic
Another trial of something that targets bone metastasis, and works even better if you are under zolendronate . "Most importantly, gamma delta T cells are unique in that they are most efficient when combined with a drug (zoledronate) that is commonly used to protect the bone in patients with bone metastatic
Maxone73
in
Advanced Prostate Cancer
14 days ago
LaRue44
My husband has metastatic prostate cancer. We went through all the treatments including 5 pluvicto treatments. Even though his scan shows improvement in some areas it continues to spread. Maybe this is due to no meds such as Xtandi to stop the spread. I'm trying to get more information by reading people's
My husband has metastatic prostate cancer. We went through all the treatments including 5 pluvicto treatments. Even though his scan shows improvement in some areas it continues to spread. Maybe this is due to no meds such as Xtandi to stop the spread. I'm trying to get more information by reading people's
LaRue44
in
Advanced Prostate Cancer
22 days ago
How about eating a healthy snack that might help fight PCa. Lotus seeds (Nelumbo nucifera) also known as makhana contain Neferine, see below
Neferine inhibits proliferation and migration of human prostate cancer stem cells through p38 MAPK/JNK activation Suat Erdogan, Kader Turkekul First published: 11 May 2020 https://doi.org/10.1111/jfbc.13253 Abstract Cancer stem cells (CSCs) are one of the significant causes of cancer treatment failure
Neferine inhibits proliferation and migration of human prostate cancer stem cells through p38 MAPK/JNK activation Suat Erdogan, Kader Turkekul First published: 11 May 2020 https://doi.org/10.1111/jfbc.13253 Abstract Cancer stem cells (CSCs) are one of the significant causes of cancer treatment failure
Graham49
in
Advanced Prostate Cancer
24 days ago
Addition of an ARSI to standard ADT significantly increases the risk of fractures and falls in men with prostate cancer
Jones C, Gray S, Brown M, et al. Risk of fractures and falls in men with advanced or metastatic prostate cancer receiving androgen deprivation therapy and treated with novel androgen receptor signalling inhibitors: a systematic review and meta-analysis of randomised controlled trials. Eur Urol Oncol.
Jones C, Gray S, Brown M, et al. Risk of fractures and falls in men with advanced or metastatic prostate cancer receiving androgen deprivation therapy and treated with novel androgen receptor signalling inhibitors: a systematic review and meta-analysis of randomised controlled trials. Eur Urol Oncol.
Graham49
in
Advanced Prostate Cancer
28 days ago
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