Analysis of results from RCTs show some drug combinations less toxic to the heart

[Graham49]

The study included the data from thirteen RCTs (16 292 patients).

For mHSPC, ADT + docetaxel + darolutamide demonstrates less cardiotoxicity than ADT + decetaxel + abiraterone acetate + prednisone due to a lower risk of hypertension and arrhythmias from decreased mineralocorticoid excess. In addition, olaparib offers decreased hypertension when superimposed on ADT + abiraterone acetate + prednisone for mCRPC treatment after prior androgen deprivation from mHSPC therapy.

Prostate Cancer Therapy Cardiotoxicity Map (PROXMAP) for Advanced Disease States: A Systematic Review and Network Meta-analysis with Bayesian Modeling of Treatment Histories

doi.org/10.1016/j.eururo.20...