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Nivolumab
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When to move on to next treatment?
Has had two infusions of ipilumumab and
nivolumab
as part of the re-formulated checkmate 650 trial- but PSA seems really high and it feels weird just watching it go up and up! Corresponding scan progression in bones. How long does one wait before it is urgent to move on?
Has had two infusions of ipilumumab and
nivolumab
as part of the re-formulated checkmate 650 trial- but PSA seems really high and it feels weird just watching it go up and up! Corresponding scan progression in bones. How long does one wait before it is urgent to move on?
joekaty
in
Advanced Prostate Cancer
5 years ago
Antitumor Activity Seen With Keytruda in mCRPC
Other studies involving PD-1 inhibitor-based combination regimens have shown activity in mCRPC, including the CheckMate 650 trial of
nivolumab
(Opdivo) plus the CTLA-4 checkpoint inhibitor ipilimumab (Yervoy) and KEYNOTE-365, which showed promising antitumor activity and well-tolerated TRAEs when pembrolizumab
Other studies involving PD-1 inhibitor-based combination regimens have shown activity in mCRPC, including the CheckMate 650 trial of
nivolumab
(Opdivo) plus the CTLA-4 checkpoint inhibitor ipilimumab (Yervoy) and KEYNOTE-365, which showed promising antitumor activity and well-tolerated TRAEs when pembrolizumab
snoraste
in
Advanced Prostate Cancer
5 years ago
Transformation Confirmed - Likely Richter’s
Options so far appear to be RChop or some version, or
Nivolumab
with Ibrutinib to prep for an allogenic transplant, or possibly a Cart T transplant (still in trails) at MDA. Are there other options to consider?
Options so far appear to be RChop or some version, or
Nivolumab
with Ibrutinib to prep for an allogenic transplant, or possibly a Cart T transplant (still in trails) at MDA. Are there other options to consider?
SarasotaPaul
in
CLL Support
5 years ago
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Screw Checkmate 650 - the “trials” of trials!
He’s getting both drugs- Ipilimumab and
Nivolumab
. The schedule is 4 treatments three weeks apart, and then Ipilimumab every 4 weeks for up to two years. One treatment in and two days later was in the hospital for colitis. Discharged after a day.
He’s getting both drugs- Ipilimumab and
Nivolumab
. The schedule is 4 treatments three weeks apart, and then Ipilimumab every 4 weeks for up to two years. One treatment in and two days later was in the hospital for colitis. Discharged after a day.
joekaty
in
Advanced Prostate Cancer
5 years ago
Update and thank you!
BUT, with an emergency steroid pack to counteract the effects of his trial meds (Ipilimumab and
nivolumab
) he made a truly remarkable recovery- has gained back almost all of the weight lost, pain manageable, and out of bed most days. At the same time, PSA continues to shoot up.
BUT, with an emergency steroid pack to counteract the effects of his trial meds (Ipilimumab and
nivolumab
) he made a truly remarkable recovery- has gained back almost all of the weight lost, pain manageable, and out of bed most days. At the same time, PSA continues to shoot up.
joekaty
in
Advanced Prostate Cancer
5 years ago
mesothelioma - anyone tried Opdivo or Yervoy?
I read about Opdivo/ Yervoy immune therapy (I believe
nivolumab
and ipilimumab are the exact drug names), could anyone share his experience? Do you think giving him intravenous injections of glucose, vitamins, protein solutions could improve his general condition?
I read about Opdivo/ Yervoy immune therapy (I believe
nivolumab
and ipilimumab are the exact drug names), could anyone share his experience? Do you think giving him intravenous injections of glucose, vitamins, protein solutions could improve his general condition?
zazi717
in
Lung Conditions Community Forum
5 years ago
Cannabis and impact on immunotherapy study published
RESULTS: In a multivariate model, cannabis was the only significant factor that reduced RR to immunotherapy (37.5% RR in
nivolumab
alone compared with 15.9% in the
nivolumab
-cannabis group (p = .016, odds ratio = 3.13, 95% confidence interval 1.24-8.1).
RESULTS: In a multivariate model, cannabis was the only significant factor that reduced RR to immunotherapy (37.5% RR in
nivolumab
alone compared with 15.9% in the
nivolumab
-cannabis group (p = .016, odds ratio = 3.13, 95% confidence interval 1.24-8.1).
missyrand
Ambassador
in
Melanoma Caregivers
5 years ago
Immunotherapy group
You can read the NICE guidelines on their website where they themselves state " it is unknown the optimum treatment duration for pembrolizumab/
nivolumab
".
You can read the NICE guidelines on their website where they themselves state " it is unknown the optimum treatment duration for pembrolizumab/
nivolumab
".
Dl1977
in
The Roy Castle Lung Cancer Foundation
5 years ago
Failing Clinical Trail
Hello My husband was in a immunotherapy clinical trial at Mount Sinai,
Nivolumab
and NKTR-214. He had first treatment September 8 and had reactions that included fever, rash, low blood pressure. Nothing we could not handle. Treatment is every three weeks 2nd tx was September 30.
Hello My husband was in a immunotherapy clinical trial at Mount Sinai,
Nivolumab
and NKTR-214. He had first treatment September 8 and had reactions that included fever, rash, low blood pressure. Nothing we could not handle. Treatment is every three weeks 2nd tx was September 30.
Hidden
in
Advanced Prostate Cancer
5 years ago
Immunotherapy 2 year limit
I went private to get a second opinion and found a great consultant who enrolled her on a early access to medicine scheme for immunotherapy (
nivolumab
) . She had 2 years on this scheme and responded amazingly with a considerable reduction in her primary lung tumour and brain metastasis.
I went private to get a second opinion and found a great consultant who enrolled her on a early access to medicine scheme for immunotherapy (
nivolumab
) . She had 2 years on this scheme and responded amazingly with a considerable reduction in her primary lung tumour and brain metastasis.
Dl1977
in
The Roy Castle Lung Cancer Foundation
5 years ago
New treatment getting fast track designation for metastatic melanoma in treatment niave patients
https://shar.es/aXgmdR Bempegaldesleukin Plus
nivolumab
The combination of bempegaldesleukin (NKTR-214) and
nivolumab
(Opdivo) was granted a breakthrough therapy designation by the FDA for the treatment of patients with previously untreated unresectable or metastatic melanoma.
https://shar.es/aXgmdR Bempegaldesleukin Plus
nivolumab
The combination of bempegaldesleukin (NKTR-214) and
nivolumab
(Opdivo) was granted a breakthrough therapy designation by the FDA for the treatment of patients with previously untreated unresectable or metastatic melanoma.
missyrand
Ambassador
in
Melanoma Caregivers
5 years ago
Initial Results from Checkmate 650, a Phase II Study of Nivolumab Plus Ipilimumab for the Treatment of Metastatic CRPC.
ASCO GU 2019: Initial Results from Checkmate 650, a Phase II Study of
Nivolumab
Plus Ipilimumab for the Treatment of Metastatic Castration-Resistant Prostate Cancer. Low response rates (10% to 25%) and significant side effects (grade 3-5 adverse events in around 50% of the patients).
ASCO GU 2019: Initial Results from Checkmate 650, a Phase II Study of
Nivolumab
Plus Ipilimumab for the Treatment of Metastatic Castration-Resistant Prostate Cancer. Low response rates (10% to 25%) and significant side effects (grade 3-5 adverse events in around 50% of the patients).
tango65
in
Advanced Prostate Cancer
5 years ago
cart t therapy or lu177
looking into the vision trial at Northwestern and a cart T trial at City of Hope. there is also a trial at U of Chicago with
Nivolumab
and Rucaparib. this is a phase 1 but i know it is being tested elsewhere but cant get any results.
looking into the vision trial at Northwestern and a cart T trial at City of Hope. there is also a trial at U of Chicago with
Nivolumab
and Rucaparib. this is a phase 1 but i know it is being tested elsewhere but cant get any results.
Eabradley
in
Advanced Prostate Cancer
5 years ago
advice on clinical trial
Doc recommends trial at U of Chicago , phase 1/1b so all patients get Rucaparib (PARP inhibitor) and
Nivolumab
. please advise as we meet on tues to sign up .. any other advise or trial info would be helpful.
Doc recommends trial at U of Chicago , phase 1/1b so all patients get Rucaparib (PARP inhibitor) and
Nivolumab
. please advise as we meet on tues to sign up .. any other advise or trial info would be helpful.
Eabradley
in
Advanced Prostate Cancer
5 years ago
Ending Nivolumab
I have almost completed my two year allocation of
Nivolumab
treatment. Is there anyone who is now being treated with
Nivolumab
for a third year? I am to see my consultant in six weeks to ask if their is a chance of an extension.
I have almost completed my two year allocation of
Nivolumab
treatment. Is there anyone who is now being treated with
Nivolumab
for a third year? I am to see my consultant in six weeks to ask if their is a chance of an extension.
foodbankcupar
in
The Roy Castle Lung Cancer Foundation
5 years ago
Treatments after Immunotherapy
After the surgery my doctors gave me
Nivolumab
. After 7 months, I had resistance again. Now I am without treatment and my doctors propose Axitinib or participate in a trial of Votrient, which is not yet approved for the use of patients who have done immunotherapy.
After the surgery my doctors gave me
Nivolumab
. After 7 months, I had resistance again. Now I am without treatment and my doctors propose Axitinib or participate in a trial of Votrient, which is not yet approved for the use of patients who have done immunotherapy.
Mafaldaaa
in
Kidney Cancer Support
5 years ago
Infusion
His enzymes were not down to perfect levels, so instead of the scheduled ipi Nivo combo, he just got a single dose of the
nivolumab
. He will get another in 3 weeks, and after that he will continue to get Nivo as maintenance every 4 weeks. That dose is higher than what he is getting currently.
His enzymes were not down to perfect levels, so instead of the scheduled ipi Nivo combo, he just got a single dose of the
nivolumab
. He will get another in 3 weeks, and after that he will continue to get Nivo as maintenance every 4 weeks. That dose is higher than what he is getting currently.
kellyOd
in
Melanoma Caregivers
5 years ago
Scan results
Once he is down to that, his oncologist is going to try and challenge his system again with BOTH the ipilimumab and the
nivolumab
. He has 2 more cycles of that, and if he can get through that would be amazing.
Once he is down to that, his oncologist is going to try and challenge his system again with BOTH the ipilimumab and the
nivolumab
. He has 2 more cycles of that, and if he can get through that would be amazing.
kellyOd
in
Melanoma Caregivers
5 years ago
CURE Magazine seeks HCC patients on immunotherapy
She would like to interview HCC patients taking Pembrolizumab (Keytruda) or
Nivolumab
(Opdivo). The deadline for the interview is Friday, April 12. If you are interested in participating, please contact Sonya directly via email at: sonya.collins@gmail.com.
She would like to interview HCC patients taking Pembrolizumab (Keytruda) or
Nivolumab
(Opdivo). The deadline for the interview is Friday, April 12. If you are interested in participating, please contact Sonya directly via email at: sonya.collins@gmail.com.
AndreaWilson_Founder
Caregiver
in
Blue Faery Liver Cancer
5 years ago
Integrating Novel Targets and Precision Medicine Into Prostate Cancer Care—Part 1: The Non-Androgen–Targetable Pathways in Castration-Resist
The combination of ipilimumab and
nivolumab
is currently being investigated in the phase II CheckMate 650 trial (ClinicalTrials.gov identifier: NCT02985957).
The combination of ipilimumab and
nivolumab
is currently being investigated in the phase II CheckMate 650 trial (ClinicalTrials.gov identifier: NCT02985957).
JLS1
in
Advanced Prostate Cancer
5 years ago
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