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Experiences with
Luteinizing hormone releasing hormone (LHRH) agonist
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Free vs Total Testosterone? - Redux.
It was also able to show that breakthrough increases of testosterone levels during
LHRH
agonist
therapy exhibited a markedly negative effect on ‘androgen-independent’ progression.
It was also able to show that breakthrough increases of testosterone levels during
LHRH
agonist
therapy exhibited a markedly negative effect on ‘androgen-independent’ progression.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
MONOTHERAPY FOR NEWLY DIAGNOSED PROSTATE CANCER
Hormone Therapies (HT) to block T include a Luteinizing Hormone-Releasing Hormone (
LHRH
)
agonist
. As of Dec 18, 2019,
LHRH
agonists available in the US include: Leuprolide (Lupron, Eligard), Goserelin (Zoladex), Histrelin (Vantas) and Triptorelin (Trelstar).
Hormone Therapies (HT) to block T include a Luteinizing Hormone-Releasing Hormone (
LHRH
)
agonist
. As of Dec 18, 2019,
LHRH
agonists available in the US include: Leuprolide (Lupron, Eligard), Goserelin (Zoladex), Histrelin (Vantas) and Triptorelin (Trelstar).
RICH22
in
Advanced Prostate Cancer
4 years ago
Surgical Castration. Why is it uncommon?
So, in sum, for the specific population of advanced prostate cancer patients, voluntary surgical castration has NOT been shown to be more psychologically stressful that androgen suppression with depot injects of
LHRH
agonist
or the antagonist degarelix.
So, in sum, for the specific population of advanced prostate cancer patients, voluntary surgical castration has NOT been shown to be more psychologically stressful that androgen suppression with depot injects of
LHRH
agonist
or the antagonist degarelix.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
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Testosterone recovery (after 6 months of ADT).
New study from Japan, below [1]. "... 125 patients with prostate cancer received 6 months of neoadjuvant ADT (nADT) followed by low-dose rate (LDR) brachytherapy." "The cumulative incidence rates of TT {total testosterone} recovery to normal levels (TT ≥ 3.0 ng/mL) after 12 and 24 months cessation were
New study from Japan, below [1]. "... 125 patients with prostate cancer received 6 months of neoadjuvant ADT (nADT) followed by low-dose rate (LDR) brachytherapy." "The cumulative incidence rates of TT {total testosterone} recovery to normal levels (TT ≥ 3.0 ng/mL) after 12 and 24 months cessation were
pjoshea13
in
Advanced Prostate Cancer
4 years ago
FET with endometriosis- what was your protocol? How much estrogens?
Happy New year everyone! I was due to start my FET ivf treatment today ( we have one embryo from a first try ) but I've decided *not to go ahead* with my clinic protocol as I believe my estrogens levels will be too high for transfer day! I've read new research saying that estrogen should ideally be
Happy New year everyone! I was due to start my FET ivf treatment today ( we have one embryo from a first try ) but I've decided *not to go ahead* with my clinic protocol as I believe my estrogens levels will be too high for transfer day! I've read new research saying that estrogen should ideally be
Lapinblanc88
in
Fertility Network UK
4 years ago
FDA-Approved Treatments for HR+, HER2- Premenopausal Patients
•An Aromatase Inhibitor without a CDK4/6 inhibitor (but with an
LHRH
agonist
). •Faslodex (Fulvestrant) either with a CDK4/6 inhibitor or alone (but with an
LHRH
agonist
.
•An Aromatase Inhibitor without a CDK4/6 inhibitor (but with an
LHRH
agonist
). •Faslodex (Fulvestrant) either with a CDK4/6 inhibitor or alone (but with an
LHRH
agonist
.
Bestbird
in
SHARE Metastatic Breast Cancer
5 years ago
Can I really rule out PID?
Hi girls, sorry for the double post today. My only symptoms are pelvic pain and bloating/pressure that goes up my ovaries and into my lower back. Firstly I was given antibiotics and told to treat it as PID, however all my STD swabs came back clear. My symptoms seemed to go away. A few months later
Hi girls, sorry for the double post today. My only symptoms are pelvic pain and bloating/pressure that goes up my ovaries and into my lower back. Firstly I was given antibiotics and told to treat it as PID, however all my STD swabs came back clear. My symptoms seemed to go away. A few months later
missusbroc
in
Endometriosis UK
5 years ago
Approved Therapies for Triple Positive (HR+, HER2+) MBC Patients
Hormonal therapy options for eligible triple positive patients in the US are listed immediately below with the understanding that premenopausal women - as well as men - should also take a Luteinizing Hormone-Releasing Hormone (
LHRH
)
agonist
such as Zoladex (Goserelin), Lupron (Leuprolide) or Trelstar
Hormonal therapy options for eligible triple positive patients in the US are listed immediately below with the understanding that premenopausal women - as well as men - should also take a Luteinizing Hormone-Releasing Hormone (
LHRH
)
agonist
such as Zoladex (Goserelin), Lupron (Leuprolide) or Trelstar
Bestbird
in
SHARE Metastatic Breast Cancer
5 years ago
Randomized trial about cardiovscular (CV) complications in patients with advanced PC & CV disease treated with GnRH agonist or antagonists.
Cardiovascular morbidity in a randomized trial comparing GnRH-agonist and GnRH-antagonist among patients with advanced prostate-cancer and pre-existing cardiovascular disease. https://www.auajournals.org/doi/10.1097/JU.0000000000000384 Less CV complications in patients treated with antagonists.
Cardiovascular morbidity in a randomized trial comparing GnRH-agonist and GnRH-antagonist among patients with advanced prostate-cancer and pre-existing cardiovascular disease. https://www.auajournals.org/doi/10.1097/JU.0000000000000384 Less CV complications in patients treated with antagonists.
tango65
in
Advanced Prostate Cancer
5 years ago
Trelstar?
I see now that Trelstar is an
LHRH
agonist
drug like Lupron and I know that Firmagon is a gonadotrophin-releasing hormone (GnRH) antagonist. All work to lower T levels.
I see now that Trelstar is an
LHRH
agonist
drug like Lupron and I know that Firmagon is a gonadotrophin-releasing hormone (GnRH) antagonist. All work to lower T levels.
shueswim
in
Advanced Prostate Cancer
5 years ago
Monotherapy or ADT3?
Hola Friends, I need advice concerning Lupron as a Monotherapy or switching to ADT(3) as suggested by Maack C (2019). Triple Hormonal Blockade (ADT3): A Patient’s Perspective. Oncogen Journal 2(1): 6. Maack says: “ Anyone moved to androgen deprivation therapy, and particularly anyone with already known
Hola Friends, I need advice concerning Lupron as a Monotherapy or switching to ADT(3) as suggested by Maack C (2019). Triple Hormonal Blockade (ADT3): A Patient’s Perspective. Oncogen Journal 2(1): 6. Maack says: “ Anyone moved to androgen deprivation therapy, and particularly anyone with already known
Frigataflyer
in
Advanced Prostate Cancer
5 years ago
Decapeptyl SR side effects
Its been a while since I posted an update, but after 40+ weeks of waiting I finally got to see gynecology. The endometriosis specialist says it sounds like I have severe endo (given the peeing blood while on my period, bleeding from behind and the extreme pain). I'm now on the complex endometriosis surgical
Its been a while since I posted an update, but after 40+ weeks of waiting I finally got to see gynecology. The endometriosis specialist says it sounds like I have severe endo (given the peeing blood while on my period, bleeding from behind and the extreme pain). I'm now on the complex endometriosis surgical
asoullessstatic
in
Endometriosis UK
5 years ago
Diethylstilbestrol [DES]
Over the years, I have known men who have used low-dose DES (Diethylstilbestrol) with some success. DES has been discussed here in a few threads. Wikipedia [1]: "DES {was a} standard initial treatment for symptomatic advanced prostate cancer for over 40 years, until the GnRH agonist leuprorelin {Lupron
Over the years, I have known men who have used low-dose DES (Diethylstilbestrol) with some success. DES has been discussed here in a few threads. Wikipedia [1]: "DES {was a} standard initial treatment for symptomatic advanced prostate cancer for over 40 years, until the GnRH agonist leuprorelin {Lupron
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Would non-curative cryo buy me time before ADT?
. -- Slightly lower dose of Lupron (or other
LHRH
agonist
), so maybe 5-10% of testosterone is still produced? Slower reduction of tumor, but maybe fewer ADT side effects. You guys know a lot! Help is much appreciated.
. -- Slightly lower dose of Lupron (or other
LHRH
agonist
), so maybe 5-10% of testosterone is still produced? Slower reduction of tumor, but maybe fewer ADT side effects. You guys know a lot! Help is much appreciated.
yeatz
in
Advanced Prostate Cancer
5 years ago
Firmagon vs Lupron
Tom Keane: I think there is, and if there isn't, there certainly should be because I do believe not all
LHRH
agonists are the same, and certainly an antagonist and an
agonist
are completely different agents. They have been used as the same agent, but I do not believe they're the same at all.
Tom Keane: I think there is, and if there isn't, there certainly should be because I do believe not all
LHRH
agonists are the same, and certainly an antagonist and an
agonist
are completely different agents. They have been used as the same agent, but I do not believe they're the same at all.
SuppWife
in
Advanced Prostate Cancer
5 years ago
Phase 3 ARCHES trial - Enzalutamide + ADT
Patients in the ARCHES trial were randomized to receive XTANDI 160 mg daily or placebo and continued on a luteinizing hormone-releasing hormone (
LHRH
)
agonist
or antagonist or had a history of bilateral orchiectomy.
Patients in the ARCHES trial were randomized to receive XTANDI 160 mg daily or placebo and continued on a luteinizing hormone-releasing hormone (
LHRH
)
agonist
or antagonist or had a history of bilateral orchiectomy.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
HOT FLASHES – Why? What to do?
This would indicate that it is the effect from the
LHRH
agonist
on the hypothalamus that brings about this “alteration.” Another cause can be attributed to
LHRH
agonist
effect on lowering male estrogen levels, since low estrogen levels also bring about hot flashes.
This would indicate that it is the effect from the
LHRH
agonist
on the hypothalamus that brings about this “alteration.” Another cause can be attributed to
LHRH
agonist
effect on lowering male estrogen levels, since low estrogen levels also bring about hot flashes.
maack1
in
Advanced Prostate Cancer
6 years ago
Really useful info from endo specialist *worth reading *
Hi ladies I have been doing lots of research recently and found this post by Dr Jeff Arrington, an endo specialist in America. I found it really helpful, so I thought I would share as I'm sure like me, there are many women here trying to figure out what to do... THE STANDARD OF CARE IS NOT SUFFICIENT
Hi ladies I have been doing lots of research recently and found this post by Dr Jeff Arrington, an endo specialist in America. I found it really helpful, so I thought I would share as I'm sure like me, there are many women here trying to figure out what to do... THE STANDARD OF CARE IS NOT SUFFICIENT
weekari
in
Endometriosis UK
6 years ago
The Importance Of Regular Scans
Biochemical failure with bone metastasis First line hormone therapy by
LHRH
Agonist
alone Continuous administration December 2008. Biochemical failure Second line hormone therapy (combined androgen blockage) July 2013.
Biochemical failure with bone metastasis First line hormone therapy by
LHRH
Agonist
alone Continuous administration December 2008. Biochemical failure Second line hormone therapy (combined androgen blockage) July 2013.
MelaniePaul
in
Advanced Prostate Cancer
6 years ago
Androgen Annihilation.
For those interested in the concept, a 2014 paper by James Mohler (Roswell Park) [1] explains it well: "Androgens may be “annihilated” using simultaneously a luteinizing hormone releasing hormone (
LHRH
) antagonist or
agonist
to inhibit testicular production of testosterone, a cytochrome P45017A1 (CYP17A1
For those interested in the concept, a 2014 paper by James Mohler (Roswell Park) [1] explains it well: "Androgens may be “annihilated” using simultaneously a luteinizing hormone releasing hormone (
LHRH
) antagonist or
agonist
to inhibit testicular production of testosterone, a cytochrome P45017A1 (CYP17A1
pjoshea13
in
Advanced Prostate Cancer
6 years ago
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