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Jakafi
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Dosing Jakafi
After 2 years on Hydrea for CALR ET, 4 weeks ago I started
jakafi
10mg twice a day . Getting cbc every two weeks has shown platelets increasing each time. When I started they were 620ish, 2 weeks later 702, Then yesterday they were 820. Now doc wants me to go to 15mg twice daily.
After 2 years on Hydrea for CALR ET, 4 weeks ago I started
jakafi
10mg twice a day . Getting cbc every two weeks has shown platelets increasing each time. When I started they were 620ish, 2 weeks later 702, Then yesterday they were 820. Now doc wants me to go to 15mg twice daily.
George1976
in
MPN Voice
1 year ago
Jakafi and H/H PCV
Hi Everyone, Hi Everyone, I was on
Jakafi
for about 5 weeks. Labs were fine 2 weeks in and then 2 weeks later Hct/hemoglobin dropped to 36 and 12. I usually run 40-42 and 13-14. Was feeling exhausted and nauseous.
Hi Everyone, Hi Everyone, I was on
Jakafi
for about 5 weeks. Labs were fine 2 weeks in and then 2 weeks later Hct/hemoglobin dropped to 36 and 12. I usually run 40-42 and 13-14. Was feeling exhausted and nauseous.
JeanieRN
in
MPN Voice
1 year ago
Jakafi’s generics: Possible delay in the entry?
, which might be a contender if approved » https://www.delveinsight.com/blog/besremi-
jakafi
-rusfertide-for-polycythemia-vera-treatment
, which might be a contender if approved » https://www.delveinsight.com/blog/besremi-
jakafi
-rusfertide-for-polycythemia-vera-treatment
Manouche
in
MPN Voice
1 year ago
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Medication choices after hydroxyurea
I have read here about interferons Pegasys and Besremi and the studies on
Jakafi
and Rusfertide. I have time to figure this out but would appreciate any input or links to the most current research before I see my hematologist in a month. I've printed out a lot of info that has been posted here.
I have read here about interferons Pegasys and Besremi and the studies on
Jakafi
and Rusfertide. I have time to figure this out but would appreciate any input or links to the most current research before I see my hematologist in a month. I've printed out a lot of info that has been posted here.
saltmarsh
in
MPN Voice
1 year ago
Shocking Price of Jakafi
I have been having lots of side effects from Hydrea, so my Dr. suggested a possible change to
Jakafi
. When I called my mail order pharmacy to price it, I was told that for a 90 day supply it would be $20,857, of which I would have to pay 33% or $6,882! How many people can do that?
I have been having lots of side effects from Hydrea, so my Dr. suggested a possible change to
Jakafi
. When I called my mail order pharmacy to price it, I was told that for a 90 day supply it would be $20,857, of which I would have to pay 33% or $6,882! How many people can do that?
dogsandhorses
in
MPN Voice
1 year ago
New to Rux
Hi everyone. Thank you all for all the useful replies I got to my last question. Two more queries here: I'm newly diagnosed with post-ET Myelofibrosis and I've just collected my first prescription of Jakavi which I haven't taken yet.I noticed that the tablets are 20mg, and I have to take 2 a day. Someone
Hi everyone. Thank you all for all the useful replies I got to my last question. Two more queries here: I'm newly diagnosed with post-ET Myelofibrosis and I've just collected my first prescription of Jakavi which I haven't taken yet.I noticed that the tablets are 20mg, and I have to take 2 a day. Someone
Sivasi
in
MPN Voice
6 days ago
New member - Post ET MF (Australia)
I'm 42, married with six children, and I live in Australia. In 2013, I was diagnosed with CAL-R positive ET. I started taking aspirin and managed pretty well. After a spontaneous bleed in my right quadricep, it was discovered that I also had a genetic bleeding disorder, dysfibrinogenemia. After that
I'm 42, married with six children, and I live in Australia. In 2013, I was diagnosed with CAL-R positive ET. I started taking aspirin and managed pretty well. After a spontaneous bleed in my right quadricep, it was discovered that I also had a genetic bleeding disorder, dysfibrinogenemia. After that
Hatchie
in
MPN Voice
7 days ago
Myelofibrosis
I have been taking Jakavi for three years after diagnosis of post-PV myelofibrosis. I get very breathless and can't walk far, but seem to cope reasonably with other activities given my age (coming up 82). I had a fall last year when my balance went quite suddenly and I passed out briefly: no signs of
I have been taking Jakavi for three years after diagnosis of post-PV myelofibrosis. I get very breathless and can't walk far, but seem to cope reasonably with other activities given my age (coming up 82). I had a fall last year when my balance went quite suddenly and I passed out briefly: no signs of
lucieboo
in
MPN Voice
8 days ago
Jakavi advice please
Hi everybodyI learned today that my ET has progressed to MF. I had a bone marrow biopsy which seems to confirm it, although a spleen scan showed my spleen is completely normal. I'm on Pegasys 135ml at the moment but platelets are 729 (going up) and not well controlled. The consultant suggests moving
Hi everybodyI learned today that my ET has progressed to MF. I had a bone marrow biopsy which seems to confirm it, although a spleen scan showed my spleen is completely normal. I'm on Pegasys 135ml at the moment but platelets are 729 (going up) and not well controlled. The consultant suggests moving
Sivasi
in
MPN Voice
23 days ago
Low saturation with PV and Jakavi 20
I have had PV since two years. Rux started december '23. Good results with HB and HCT. HB is pretty low now 7.7 for a while. My weight has increased 10% wit the same diet. My saturation is, in rest 92, with effort I can raise it to 93/94. Long test last week revealed a very good lung condition (5,7
I have had PV since two years. Rux started december '23. Good results with HB and HCT. HB is pretty low now 7.7 for a while. My weight has increased 10% wit the same diet. My saturation is, in rest 92, with effort I can raise it to 93/94. Long test last week revealed a very good lung condition (5,7
Quitojohn
in
MPN Voice
2 months ago
FDA Issues Complete Response Letter for Ruxolitinib Extended-Release Tablets
Ruxolitinib, a Janus kinas (JAK)1/JAK2 inhibitor, is currently marketed under the brand name
Jakafi
for the treatment of myelofibrosis, polycythemia vera, and GVHD.
Jakafi
is supplied in 5mg, 10mg, 15mg, 20mg, and 25mg tablets.
Ruxolitinib, a Janus kinas (JAK)1/JAK2 inhibitor, is currently marketed under the brand name
Jakafi
for the treatment of myelofibrosis, polycythemia vera, and GVHD.
Jakafi
is supplied in 5mg, 10mg, 15mg, 20mg, and 25mg tablets.
PhysAssist
in
MPN Voice
1 year ago
jackafi and and exhaustion
I have been on
Jakafi
17 days and I am exhausted. I have my blood work tomorrow. I did not experience this with Besremi. Has anyone else experienced with Jackafi? Thanks in advance! Jeanie
I have been on
Jakafi
17 days and I am exhausted. I have my blood work tomorrow. I did not experience this with Besremi. Has anyone else experienced with Jackafi? Thanks in advance! Jeanie
JeanieRN
in
MPN Voice
1 year ago
Ruxolitinib (Jakafi) ; A generic ?
When will this drug be off patent or available as a generic? Any ideas?
When will this drug be off patent or available as a generic? Any ideas?
Innessant
in
MPN Voice
7 months ago
Imetelstat Users?
Hi All, I have Myelofibrosis and have been taking Jakavi for about 3 years, and it has been pretty successful in suppressing my symptoms. Unfortunately my symptoms are slowly returning, my spleen has enlarged to 215mm and a bone marrow biopsy has shown that the fibrosis is now pretty advanced. I
Hi All, I have Myelofibrosis and have been taking Jakavi for about 3 years, and it has been pretty successful in suppressing my symptoms. Unfortunately my symptoms are slowly returning, my spleen has enlarged to 215mm and a bone marrow biopsy has shown that the fibrosis is now pretty advanced. I
TimGS
in
MPN Voice
5 months ago
Weight gain on Jakafi ?
Hi, I was diagnosed Jak2 gene last year April (PV) and didn’t tolerate hydrea nor was it having any effect… Now progressed to 20mg
Jakafi
and a side effect (I was told) can be weight gain… At first no gain but I did notice getting a more pronounced sweet tooth after a month on 20mg ☺️.
Hi, I was diagnosed Jak2 gene last year April (PV) and didn’t tolerate hydrea nor was it having any effect… Now progressed to 20mg
Jakafi
and a side effect (I was told) can be weight gain… At first no gain but I did notice getting a more pronounced sweet tooth after a month on 20mg ☺️.
Anouchka
in
MPN Voice
1 year ago
Treating leukocytosis in PV
I've been on
Jakafi
for about six months, and my current dosage of 10 mg/day seems to be doing a good job of controlling my HCT, HGB, and PLT numbers. However, my WBC numbers are consistently high, running at 19-20 K/uL.
I've been on
Jakafi
for about six months, and my current dosage of 10 mg/day seems to be doing a good job of controlling my HCT, HGB, and PLT numbers. However, my WBC numbers are consistently high, running at 19-20 K/uL.
sbs_patient
in
MPN Voice
1 year ago
On Pegasys 180 for 2 months.
Had been on Hydroxyurea combined with pegasysThen 3 months ago after 33 to 90 to 135 I was upped to 180 1x per week. Hu was discontinued. Now latest platlet count are climbing back up, lowest they got 575, 2weeks later 755. LT, AST, ALT numbers spiked as well. Injection Have caused pain in my side
Had been on Hydroxyurea combined with pegasysThen 3 months ago after 33 to 90 to 135 I was upped to 180 1x per week. Hu was discontinued. Now latest platlet count are climbing back up, lowest they got 575, 2weeks later 755. LT, AST, ALT numbers spiked as well. Injection Have caused pain in my side
ETMF
in
MPN Voice
6 months ago
sjogens?
I have post PV Myelofibrosis. When I was dx with PV I took Pegasys from April 22 @ 45mg then 60mg then 90mg fortnightly. (On Jakavi since August 23) So took Pegasys for about 16 months After a couple of months on Pegasys I started to experience close vision problems which could not be corrected with
I have post PV Myelofibrosis. When I was dx with PV I took Pegasys from April 22 @ 45mg then 60mg then 90mg fortnightly. (On Jakavi since August 23) So took Pegasys for about 16 months After a couple of months on Pegasys I started to experience close vision problems which could not be corrected with
Yanico
in
MPN Voice
6 months ago
Palbociclib for MF reducing fibrosis and more
reduced leukocytosis and splenomegaly and inhibited bone marrow fibrosis in Jak2V617F and MPLW515L mouse models of myelofibrosis https://pubmed.ncbi.nlm.nih.gov/34145036/ -- and another author's wording "“We demonstrate that CDK4/6 inhibitor palbociclib (Ibrance) in combination with ruxolitinib (
Jakafi
reduced leukocytosis and splenomegaly and inhibited bone marrow fibrosis in Jak2V617F and MPLW515L mouse models of myelofibrosis https://pubmed.ncbi.nlm.nih.gov/34145036/ -- and another author's wording "“We demonstrate that CDK4/6 inhibitor palbociclib (Ibrance) in combination with ruxolitinib (
Jakafi
EPguy
in
MPN Voice
28 days ago
Hair Loss on Hydrea
I too loss lots of hair while taking Hydrea, then Anagrelide, and finally
Jakafi
. After starting to an MPN Specialist almost 2 yrs ago & switching to Pegasys, my hair is coming back in. My hair dresser is amazed at how much regrowth I’ve had.
I too loss lots of hair while taking Hydrea, then Anagrelide, and finally
Jakafi
. After starting to an MPN Specialist almost 2 yrs ago & switching to Pegasys, my hair is coming back in. My hair dresser is amazed at how much regrowth I’ve had.
Golfersmom
in
MPN Voice
1 year ago
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