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Interferon
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Is anyone concerned on the side-effect of taking hydroxyurea for long time?
I heard
Interferon
is much better than HU and has chance to change JAK2 + to negative. Anyone any recommendation? I am JAK2+ with platelets ~600
I heard
Interferon
is much better than HU and has chance to change JAK2 + to negative. Anyone any recommendation? I am JAK2+ with platelets ~600
Sam2022
in
MPN Voice
3 years ago
Post 746 Powerlessness NOT YOU 10 Jul 2021
Back in the day, when I was on Beta 1b
interferon
, each needle I used to imagine. The medicine going into my bloodstream and flowing around my body. Building barriers, repairing damage that ms had caused. Not getting all the damage, but some.
Back in the day, when I was on Beta 1b
interferon
, each needle I used to imagine. The medicine going into my bloodstream and flowing around my body. Building barriers, repairing damage that ms had caused. Not getting all the damage, but some.
RoyceNewton
in
My MSAA Community
3 years ago
More variants TLR7 gene found in young healthy men with severe Covid-19.
Spanish-Dutch research has revealed two new mutations in the TLR7 gene in healthy young men who became seriously ill with severe Covid-19. It’s becoming increasingly plausible that such mutations undermine a sufficient immune response against SARS-CoV-2, the researchers write in Frontiers in Immunology
Spanish-Dutch research has revealed two new mutations in the TLR7 gene in healthy young men who became seriously ill with severe Covid-19. It’s becoming increasingly plausible that such mutations undermine a sufficient immune response against SARS-CoV-2, the researchers write in Frontiers in Immunology
2greys
in
Lung Conditions Community Forum
3 years ago
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Advice wanted
I was initially put on
Interferon
but could not tolerate the fevers especially with a 1 year old. Haven't been on any medication for MD since, platelets are 200. I have now got a rash lower part of my legs which burns and sometimes itches and feel I am getting it on my hands also.
I was initially put on
Interferon
but could not tolerate the fevers especially with a 1 year old. Haven't been on any medication for MD since, platelets are 200. I have now got a rash lower part of my legs which burns and sometimes itches and feel I am getting it on my hands also.
taytokavo
in
MPN Voice
3 years ago
Implications of butyrate and its derivatives for gut health and animal production 2018
The anti-inflammatory properties of butyrate have been shown to be mediated by several mechanisms including: the reduction of pro-inflammatory cytokine expression (
interferon
gamma [IFN-γ], tumor necrosis factor-α [TNF-α], interleukin-1B [IL-1B], IL-6, IL-8), the induction of IL-10 and transforming growth
The anti-inflammatory properties of butyrate have been shown to be mediated by several mechanisms including: the reduction of pro-inflammatory cytokine expression (
interferon
gamma [IFN-γ], tumor necrosis factor-α [TNF-α], interleukin-1B [IL-1B], IL-6, IL-8), the induction of IL-10 and transforming growth
Bolt_Upright
in
Cure Parkinson's
3 years ago
Greater Understanding of PV, ET Drives Potential New Treatment Options
For example, a phase 2 study of ruxolitinib in combination with pegylated
interferon
alfa 2a (PEG-IFN alfa-2a) found the regimen was well tolerated, decreased JAK2 V617F allelic burden and symptoms, and resulted in remission for 10 of the 32 patients with PV deemed “almost entirely” intolerant or refractory
For example, a phase 2 study of ruxolitinib in combination with pegylated
interferon
alfa 2a (PEG-IFN alfa-2a) found the regimen was well tolerated, decreased JAK2 V617F allelic burden and symptoms, and resulted in remission for 10 of the 32 patients with PV deemed “almost entirely” intolerant or refractory
Manouche
in
MPN Voice
3 years ago
Research identifies potential antiviral compound for COVID-19, flu, other viral infection
A trigger for the STING (stimulator of
interferon
genes) pathway, the compound, diamidobenzimidazole (diABZI-4), protected animal models and human cells in the lab from SARS-CoV-2 infection.
A trigger for the STING (stimulator of
interferon
genes) pathway, the compound, diamidobenzimidazole (diABZI-4), protected animal models and human cells in the lab from SARS-CoV-2 infection.
2greys
in
Lung Conditions Community Forum
3 years ago
Interferon side effects?
She is recommending I switch over to a once weekly shot of
interferon
to get my platelets down to 400k range. I tolerate the HU and aspirin well (no side effects) and I’m active and in good health.
She is recommending I switch over to a once weekly shot of
interferon
to get my platelets down to 400k range. I tolerate the HU and aspirin well (no side effects) and I’m active and in good health.
jevans59
in
MPN Voice
3 years ago
Covid jab and interferon injection
Iam due to have my
interferon
injection this evening. (45MG EVERY OTHER WEEK) wondering if it is OK to still have my injection same day as my covid jab Many thanks
Iam due to have my
interferon
injection this evening. (45MG EVERY OTHER WEEK) wondering if it is OK to still have my injection same day as my covid jab Many thanks
Elab
in
MPN Voice
3 years ago
Interferon Injections tummy feels bruised.
Just wondering if you can inject
Interferon
in the arm or buttock region. Thankyou
Just wondering if you can inject
Interferon
in the arm or buttock region. Thankyou
vegas22
in
MPN Voice
3 years ago
Interferon Cough
I'm convinced I have the 'cough' , consultant not convinced.. Anyone else have the same and what are your symptoms? Is it a productive cough Treatment?
I'm convinced I have the 'cough' , consultant not convinced.. Anyone else have the same and what are your symptoms? Is it a productive cough Treatment?
shiftzz
in
MPN Voice
3 years ago
Unnumbered post Look for alternatives 12 May 2021
Back when I started Australia had two choices, Beta
Interferon
or nothing. My dear departed Grandmother and dear Mother saw that I had no choice, it was
Interferon
Beta with needles or it was Beta
interferon
.
Back when I started Australia had two choices, Beta
Interferon
or nothing. My dear departed Grandmother and dear Mother saw that I had no choice, it was
Interferon
Beta with needles or it was Beta
interferon
.
RoyceNewton
in
My MSAA Community
3 years ago
ASCO presentations on melanoma research this week
ASC0 released adjuvant clinical trial from 2015-17 cohort comparing Keytruda vs Yervoy vs high dose
interferon
for Stage 3A-4 melanoma patients. Adjuvant Anti-PD-1 Misses on Overall Survival (OS) in High-Risk Melanoma, but pembrolizumab topped active controls for relapse-free survival.
ASC0 released adjuvant clinical trial from 2015-17 cohort comparing Keytruda vs Yervoy vs high dose
interferon
for Stage 3A-4 melanoma patients. Adjuvant Anti-PD-1 Misses on Overall Survival (OS) in High-Risk Melanoma, but pembrolizumab topped active controls for relapse-free survival.
missyrand
Ambassador
in
Melanoma Caregivers
3 years ago
PEG-Interferon and bowel side-effects
Thus the decision was made to switch me to PEG-
Interferon
, at least for a while, to see if that would help the ulcer to heal.
Thus the decision was made to switch me to PEG-
Interferon
, at least for a while, to see if that would help the ulcer to heal.
JaK2ET
in
MPN Voice
3 years ago
Testosterone & Covid-19
"With respect to inflammatory markers, testosterone concentrations were inversely and significantly associated with interleukin 6, C-reactive protein, interleukin 1 receptor antagonist, hepatocyte growth factor, and
interferon
γ–inducible protein 10 in men.
"With respect to inflammatory markers, testosterone concentrations were inversely and significantly associated with interleukin 6, C-reactive protein, interleukin 1 receptor antagonist, hepatocyte growth factor, and
interferon
γ–inducible protein 10 in men.
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Post 743 Ocrevus my reasoning 23 Jun 2021
Let us also mention my dislike of needles, I did
Interferon
-beta 1b years ago and that is enough needles for this lifetime. “YOU” on the other hand may well want to consider it strongly. It is only two infusions a year I believe.
Let us also mention my dislike of needles, I did
Interferon
-beta 1b years ago and that is enough needles for this lifetime. “YOU” on the other hand may well want to consider it strongly. It is only two infusions a year I believe.
RoyceNewton
in
My MSAA Community
3 years ago
“Interferon” with MPN hematopoietic stem cells
forms of
interferon
(IFN) has provided renewed interest for use of this agent in the clinical setting.
forms of
interferon
(IFN) has provided renewed interest for use of this agent in the clinical setting.
Manouche
in
MPN Voice
3 years ago
Cytoreductive surgery for Oligometastatic PCa.
Radical nephrectomy plus
interferon
-alfa-based immunotherapy compared with
interferon
alfa alone in metastatic renal-cell carcinoma: a randomised trial. Lancet (London, England). 2001;358(9286):966–70. - DOI Bristow RE, Tomacruz RS, Armstrong DK, Trimble EL, Montz FJ.
Radical nephrectomy plus
interferon
-alfa-based immunotherapy compared with
interferon
alfa alone in metastatic renal-cell carcinoma: a randomised trial. Lancet (London, England). 2001;358(9286):966–70. - DOI Bristow RE, Tomacruz RS, Armstrong DK, Trimble EL, Montz FJ.
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Hydroxicarbamide to interferon
I may have to change from HU after 12 years ( suits me fine but is now possibly causing bcc’s ) to
interferon
. Has anyone else migrated from hydroxicarbamide to
interferon
and had any reactions?
I may have to change from HU after 12 years ( suits me fine but is now possibly causing bcc’s ) to
interferon
. Has anyone else migrated from hydroxicarbamide to
interferon
and had any reactions?
Loubprv
Volunteer
in
MPN Voice
3 years ago
Covid antibodies
I was at my hospital for usual bloods pre starting
interferon
next month. They also tested me for covid antibodies as I had my second jab the week before. Does anyone know what a good value is for the antibodies and is a week to soon for them to have developed fully?
I was at my hospital for usual bloods pre starting
interferon
next month. They also tested me for covid antibodies as I had my second jab the week before. Does anyone know what a good value is for the antibodies and is a week to soon for them to have developed fully?
Jonnymitts
in
MPN Voice
3 years ago
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