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Idelalisib
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ASH 2015: Dr. John M Pagel on the Problems with Idelalisib as Frontline Therapy in CLL
It has been a while since I posted an interview on my blog first instead of the CLL Society website, but I thought the contrast of the broad approval of ibrutinib frontline versus the unexpected findings of significant auto-immune toxicities especially in the liver with
idelalisib
frontline needed to
It has been a while since I posted an interview on my blog first instead of the CLL Society website, but I thought the contrast of the broad approval of ibrutinib frontline versus the unexpected findings of significant auto-immune toxicities especially in the liver with
idelalisib
frontline needed to
bkoffman
CLL CURE Hero
in
CLL Support
8 years ago
World Cancer Day
myelogenous leukemia) are the poster children for the development of biological (think monoclonal antibodies such as rituximab) and targeted non-chemo therapies such as imatinib or Gleevec for CML (the first truly targeted therapy and a true miracle drug) and the game changing oral medications, ibrutinib and
idelalisib
myelogenous leukemia) are the poster children for the development of biological (think monoclonal antibodies such as rituximab) and targeted non-chemo therapies such as imatinib or Gleevec for CML (the first truly targeted therapy and a true miracle drug) and the game changing oral medications, ibrutinib and
idelalisib
bkoffman
CLL CURE Hero
in
CLL Support
8 years ago
Ibrutinb or Idelalisib not working? Patients swapping had mostly favourable outcomes according to a study of 178 CLL patients.
[u]Responses were most durable for patients who discontinued ibrutinib or
idelalisib
because they experienced side effects that made it difficult for them to continue taking the drug[/u]."
[u]Responses were most durable for patients who discontinued ibrutinib or
idelalisib
because they experienced side effects that made it difficult for them to continue taking the drug[/u]."
AussieNeil
Partner
in
CLL Support
8 years ago
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Offer of enrolling on CALiBRe trial
I saw Prof Andrew Pettitt at Liverpool Royal yesterday and he has offered me access to the CALiBRe trial taking only
Idelalisib
. I can only find info on people who have had previous treatments and receive the drug in combination with Rituximab and who also have the 17p deletion.
I saw Prof Andrew Pettitt at Liverpool Royal yesterday and he has offered me access to the CALiBRe trial taking only
Idelalisib
. I can only find info on people who have had previous treatments and receive the drug in combination with Rituximab and who also have the 17p deletion.
kendo1
in
CLL Support
8 years ago
Adventures with Idelalisib - a ruptured spleen - (Part One)
I felt GOOD… :-) https://healthunlocked.com/cllsupport/posts/132279121/one-week-after-starting-
idelalisib
-%E2%80%93-or-%E2%80%9Cany-advance-on-a-wbc-of-480%E2%80%9D However, after a couple of months I developed a nasty rash, so was advised to stop the Idela (doctor’s shorthand for
Idelalisib
), for
I felt GOOD… :-) https://healthunlocked.com/cllsupport/posts/132279121/one-week-after-starting-
idelalisib
-%E2%80%93-or-%E2%80%9Cany-advance-on-a-wbc-of-480%E2%80%9D However, after a couple of months I developed a nasty rash, so was advised to stop the Idela (doctor’s shorthand for
Idelalisib
), for
PaulaS
Volunteer
in
CLL Support
8 years ago
NICE publish final guidance for idelalisib to treat CLL, moving England and Wales NHS access closer
NICE published Final Guidance today on
Idelalisib
for treating chronic lymphocytic leukaemia NICE technology appraisal guidance [TA359] http://www.nice.org.uk/guidance/TA359 This publishing of final guidance moves the treatment of
idelalisib
plus rituximab one step closer to NHS availability for England
NICE published Final Guidance today on
Idelalisib
for treating chronic lymphocytic leukaemia NICE technology appraisal guidance [TA359] http://www.nice.org.uk/guidance/TA359 This publishing of final guidance moves the treatment of
idelalisib
plus rituximab one step closer to NHS availability for England
HAIRBEAR_UK
Administrator
in
CLL Support
9 years ago
Integrating Emerging Evidence Into the Management of CLL Patients; what leading CLL experts recommend in 4 case studies
Watch and Wait Patients taking
Idelalisib
will be most interested in the information on the typical onset times of self-limiting and severe diarrhoea/colitis and how it may be controlled with Budesonide (slides 70 - 72) and transanimase elevations - liver function ALT or AST elevations (slides 73 -
Watch and Wait Patients taking
Idelalisib
will be most interested in the information on the typical onset times of self-limiting and severe diarrhoea/colitis and how it may be controlled with Budesonide (slides 70 - 72) and transanimase elevations - liver function ALT or AST elevations (slides 73 -
AussieNeil
Partner
in
CLL Support
9 years ago
PaulaS - news for friends
- A week ago
Idelalisib
was withdrawn because of worsening rash. - 2 days later she was admitted to hospital with fever (presumed to be chest infection) - Once off
Idelalisib
, her spleen enlarged very quickly.
- A week ago
Idelalisib
was withdrawn because of worsening rash. - 2 days later she was admitted to hospital with fever (presumed to be chest infection) - Once off
Idelalisib
, her spleen enlarged very quickly.
PeterMasih
in
CLL Support
9 years ago
International Working Group CLL 2015 (IW CLL 2015) Highlights
•Ibrutinib; Atrial Fibrillation / bleeding & bruising / diarrhea & colitis •
Idelalisib
; colitis / rash / & some abnormal liver function lab values •John Gribben spoke brilliantly about the role of "T cell exhaustion" & failure of T cell mediated immune-surveillance in the pathogenesis of CLL.
•Ibrutinib; Atrial Fibrillation / bleeding & bruising / diarrhea & colitis •
Idelalisib
; colitis / rash / & some abnormal liver function lab values •John Gribben spoke brilliantly about the role of "T cell exhaustion" & failure of T cell mediated immune-surveillance in the pathogenesis of CLL.
daisyruby1
in
CLL Support
9 years ago
Dr. Shpall on Therapeutic Agents for the Treatment of CLL
Shpall, MD, professor, deputy department chair, Department of Stem Cell Transplantation, Division of Cancer Medicine, medical director, Cell Therapy Laboratory, director, Cord Blood Bank, the University of Texas MD Anderson Cancer Center, discusses
idelalisib
and ibrutinib for the treatment of patients
Shpall, MD, professor, deputy department chair, Department of Stem Cell Transplantation, Division of Cancer Medicine, medical director, Cell Therapy Laboratory, director, Cord Blood Bank, the University of Texas MD Anderson Cancer Center, discusses
idelalisib
and ibrutinib for the treatment of patients
Justasheet1
in
CLL Support
9 years ago
Idelalisib Plus Rituximab Highly Active in Treatment-Naïve Older Patients With CLL
This is a 'good news' story for CLL patients: http://www.cancertherapyadvisor.com/chronic-lymphocytic-leukemia/chronic-leukemia-cll-idelasib-rituximab-highly-active-treatment-older/article/447548/?DCMP=EMC-CTA_weekly&cpn=&hmSubId=yb1KkwzD43Y1&hmEmail=X-CuWXoBB--vMqNompZbUN9Sz-y1cfMN0&NID=&spMailingID
This is a 'good news' story for CLL patients: http://www.cancertherapyadvisor.com/chronic-lymphocytic-leukemia/chronic-leukemia-cll-idelasib-rituximab-highly-active-treatment-older/article/447548/?DCMP=EMC-CTA_weekly&cpn=&hmSubId=yb1KkwzD43Y1&hmEmail=X-CuWXoBB--vMqNompZbUN9Sz-y1cfMN0&NID=&spMailingID
wmay13241
in
CLL Support
9 years ago
Another new one
I had bendamustine, Rituxan, and
Idelalisib
as part of a clinical trial but failed the
Idelalisib
part. Remission should last a few years and then I'll be back at it again. I'm especially interested in the research for obvious reasons. Looking forward to learning all I can!
I had bendamustine, Rituxan, and
Idelalisib
as part of a clinical trial but failed the
Idelalisib
part. Remission should last a few years and then I'll be back at it again. I'm especially interested in the research for obvious reasons. Looking forward to learning all I can!
Eagle5327
in
CLL Support
9 years ago
Initial Safety Report Finds Acceptable Safety With Ibrutinib for Asymptomatic, High-Risk CLL
However, the CLL subtype responds to treatment with ibrutinib as well as
idelalisib
, another novel oral kinase inhibitor.
However, the CLL subtype responds to treatment with ibrutinib as well as
idelalisib
, another novel oral kinase inhibitor.
AussieNeil
Partner
in
CLL Support
9 years ago
Your opportunity to support affordable access to Ibrutinib and Idelalisib for Aussies - Submissions close next Wed 7th October
Australia's November Pharmaceutical Benefits Advisory Committe (PBAC) meeting will consider listing
Idelalisib
and Ibrutinib for CLL patients.
Australia's November Pharmaceutical Benefits Advisory Committe (PBAC) meeting will consider listing
Idelalisib
and Ibrutinib for CLL patients.
AussieNeil
Partner
in
CLL Support
9 years ago
Statistical analysis of REACH trial patients identifies Progression Free Survival prognostic factor for FCR patients
Why is this news about FCR - an 'old' immunochemotherapy treatment, so important now that we have non-chemotherapy treatments like Ibrutinib and
Idelalisib
? Many CLL specialists recognise that for some CLL patients, FCR may be a better choice.
Why is this news about FCR - an 'old' immunochemotherapy treatment, so important now that we have non-chemotherapy treatments like Ibrutinib and
Idelalisib
? Many CLL specialists recognise that for some CLL patients, FCR may be a better choice.
AussieNeil
Partner
in
CLL Support
9 years ago
The inaugural CLL Tribune
Brown on
idelalisib
, and a lot more. Please let us know what you think of it as a whole or any particular articles. I would like feedback on the work I did in the BASICS section on what is CLL with text and linked videos. Want the next one to be even better.
Brown on
idelalisib
, and a lot more. Please let us know what you think of it as a whole or any particular articles. I would like feedback on the work I did in the BASICS section on what is CLL with text and linked videos. Want the next one to be even better.
bkoffman
CLL CURE Hero
in
CLL Support
9 years ago
Dr. Byrd on trial design and getting drugs to market
Jennifer Brown gives practical advice on
idelalisib
; I cover the basics of just what is CLL/SLL and more in a monolog and transcription; plus several patients including WWW have written diverse and helpful articles.
Jennifer Brown gives practical advice on
idelalisib
; I cover the basics of just what is CLL/SLL and more in a monolog and transcription; plus several patients including WWW have written diverse and helpful articles.
bkoffman
CLL CURE Hero
in
CLL Support
9 years ago
Bright future? Only if we keep pushing!
Jennifer Brown on
idelalisib
. Stay strong. We are all in this together. Brian http://cllsociety.org http://bkoffman.blogspot.com
Jennifer Brown on
idelalisib
. Stay strong. We are all in this together. Brian http://cllsociety.org http://bkoffman.blogspot.com
bkoffman
CLL CURE Hero
in
CLL Support
9 years ago
InPractice CLL reference update - Idelalisib+Ofatumumab for relapsed/refractory patients. (Another CLL reference worth bookmarking)
The comprehensive InPractice reference for diagnosing, monitoring and treating CLL is regularly updated, with the latest update incorporating the addition of ofatumumab to
idelalisib
in patients with relapsed/refractory CLL plus the initial results from HELIOS trial of ibrutinib added to BR.
The comprehensive InPractice reference for diagnosing, monitoring and treating CLL is regularly updated, with the latest update incorporating the addition of ofatumumab to
idelalisib
in patients with relapsed/refractory CLL plus the initial results from HELIOS trial of ibrutinib added to BR.
AussieNeil
Partner
in
CLL Support
9 years ago
Update
He has been receiving
Idelalisib
+Rituximab for 2 weeks now and all is well at the moment. His blood counts were good today and as he is feeling so much better on this treatment Dr Bloor does not want to see him again for 3 months.
He has been receiving
Idelalisib
+Rituximab for 2 weeks now and all is well at the moment. His blood counts were good today and as he is feeling so much better on this treatment Dr Bloor does not want to see him again for 3 months.
june65
in
CLL Support
9 years ago
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