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Enzalutamide
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Abiraterone after Docetaxel for mCSPC?
- I have seen that
enzalutamide
(AFFIRM study) and apalutamide (TITAN study) extend overall survival for high burden castrate sensitive prostate cancer, but not for men like me who have already had docetaxel, but the data was limited for those subgroups.
- I have seen that
enzalutamide
(AFFIRM study) and apalutamide (TITAN study) extend overall survival for high burden castrate sensitive prostate cancer, but not for men like me who have already had docetaxel, but the data was limited for those subgroups.
john205
in
Advanced Prostate Cancer
5 years ago
Veru-111 Advice
He has castration-resistant prostate cancer with progression despite abiraterone,
enzalutamide
, and docetaxel chemotherapy. About 4 months ago, he began treatment with radium-223, and has received 5 of 6 infusions thus far. His oncologist does not feel he needs to complete the 6th.
He has castration-resistant prostate cancer with progression despite abiraterone,
enzalutamide
, and docetaxel chemotherapy. About 4 months ago, he began treatment with radium-223, and has received 5 of 6 infusions thus far. His oncologist does not feel he needs to complete the 6th.
Amandaslp78
in
Advanced Prostate Cancer
5 years ago
One month on Xtandi with mCRPC
Thanks to all who responded to my post about the cost of Xtandi (
Enzalutamide
). I did get help from the Patient Assistance Network. I am very grateful.
Thanks to all who responded to my post about the cost of Xtandi (
Enzalutamide
). I did get help from the Patient Assistance Network. I am very grateful.
xpbdb
in
Advanced Prostate Cancer
5 years ago
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Use of Rx drugs and botanical compounds to prevent chemo drug-resistance with Docetaxel.
Enzalutamide
(xtandi) ADT (androgen deprivation therapy) First-line
enzalutamide
, docetaxel combination improves disease control in advanced prostate cancer February 15, 2019 https://www.healio.com/hematology-oncology/prostate-cancer/news/online/%7B6975a5a4-b882-4165-9963-f30e9d9dad8b%7D/first-line-
enzalutamide
-docetaxel-combination-improves-disease-control-in-advanced-prostate-cancer
Enzalutamide
(xtandi) ADT (androgen deprivation therapy) First-line
enzalutamide
, docetaxel combination improves disease control in advanced prostate cancer February 15, 2019 https://www.healio.com/hematology-oncology/prostate-cancer/news/online/%7B6975a5a4-b882-4165-9963-f30e9d9dad8b%7D/first-line-
enzalutamide
-docetaxel-combination-improves-disease-control-in-advanced-prostate-cancer
chillpill7
in
Advanced Prostate Cancer
5 years ago
Onvansertib Helps Overcome Resistance to Zytiga in mCRPC Patients, Interim Phase 2 Data Show
These patients are resistant to ARS inhibitors including Zytiga and Xtandi (
enzalutamide
, by Astellas and Pfizer) and their therapeutic options are not only limited, but often ineffective,” Erlander said. Onvansertib add-on therapy was generally safe and well-tolerated.
These patients are resistant to ARS inhibitors including Zytiga and Xtandi (
enzalutamide
, by Astellas and Pfizer) and their therapeutic options are not only limited, but often ineffective,” Erlander said. Onvansertib add-on therapy was generally safe and well-tolerated.
Philly13
in
Advanced Prostate Cancer
4 years ago
Is BAT repeatable?
It should be born in mind that the BAT treatment has so far been shown to be helpful in cases of resistance to abiraterone and
enzalutamide
. Mine is the first “experiment” I know of to use it to manage resistance to bicalutamide. I have not been exposed to abi or enza (or chemo for that matter).
It should be born in mind that the BAT treatment has so far been shown to be helpful in cases of resistance to abiraterone and
enzalutamide
. Mine is the first “experiment” I know of to use it to manage resistance to bicalutamide. I have not been exposed to abi or enza (or chemo for that matter).
kaptank
in
Advanced Prostate Cancer
5 years ago
Talapro 2 one week in
One week ago Sept 23 I started the Talapro 2 clinical trial (talazoprib/placebo with
enzalutamide
) and immediately jetted of to Hawaii. Notice a bit more fatigue than just the lupron. And maybe a bit looser bowl. But so far all side effects are very manageable.
One week ago Sept 23 I started the Talapro 2 clinical trial (talazoprib/placebo with
enzalutamide
) and immediately jetted of to Hawaii. Notice a bit more fatigue than just the lupron. And maybe a bit looser bowl. But so far all side effects are very manageable.
Maleko808
in
Advanced Prostate Cancer
5 years ago
Xtandi (enzalutamide) hacks
I'll see what the labs tell me, and then try a full dose of 4
enzalutamide
. I've been almost afraid to say anything to anyone for fear that this isn't real. If it's placebo - it's a good one!
I'll see what the labs tell me, and then try a full dose of 4
enzalutamide
. I've been almost afraid to say anything to anyone for fear that this isn't real. If it's placebo - it's a good one!
Escudilla
in
Advanced Prostate Cancer
5 years ago
Enzalutamide + Abiraterone Acetate in Bone CRPC
INTERVENTION:
Enzalutamide
160mg and abiraterone acetate 1000mg once daily; prednisone 5mg twice daily.
INTERVENTION:
Enzalutamide
160mg and abiraterone acetate 1000mg once daily; prednisone 5mg twice daily.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Olaparib Phase III trial
Lynparza Phase III PROfound trial in HRR vs.
enzalutamide
or abiraterone Maybe this positive result from a phase III trial could help some of you? https://otp.tools.investis.com/clients/uk/astrazeneca/rns/regulatory-story.aspx?
Lynparza Phase III PROfound trial in HRR vs.
enzalutamide
or abiraterone Maybe this positive result from a phase III trial could help some of you? https://otp.tools.investis.com/clients/uk/astrazeneca/rns/regulatory-story.aspx?
Claud68
in
Advanced Prostate Cancer
5 years ago
Come to end of treatment line after R223. Nothing else available.
I have asked about Apalutamide and Daralutamide and been told these are variations on
enzalutamide
so won’t work. Also been told there’s no point doing chemo again. 😢 Any advice greatly appreciated.
I have asked about Apalutamide and Daralutamide and been told these are variations on
enzalutamide
so won’t work. Also been told there’s no point doing chemo again. 😢 Any advice greatly appreciated.
JP63
in
Advanced Prostate Cancer
5 years ago
Cost Effectiveness of Abiraterone vs Docetaxel in the Treatment of Hormone-Naïve Prostate Cancer
of seven prospectively randomized studies of patients with newly diagnosed, hormone-naïve metastatic prostate cancer, comparing various combinations of standard gonadal androgen-deprivation treatment (ADT) with either docetaxel or one of the novel androgen receptor (AR)–targeting drugs (abiraterone,
enzalutamide
of seven prospectively randomized studies of patients with newly diagnosed, hormone-naïve metastatic prostate cancer, comparing various combinations of standard gonadal androgen-deprivation treatment (ADT) with either docetaxel or one of the novel androgen receptor (AR)–targeting drugs (abiraterone,
enzalutamide
Balsam01
in
Advanced Prostate Cancer
5 years ago
Xtandi Availability at Reasonable Cost
Saw this article from 4/28/2016, "Biolyse Pharma offers to supply
enzalutamide
(Xtandi) for $3 per pill to Medicare and developing countries " - does anyone know if Xtandi can be had for $3 per pill or less in Canada or anywhere else?
Saw this article from 4/28/2016, "Biolyse Pharma offers to supply
enzalutamide
(Xtandi) for $3 per pill to Medicare and developing countries " - does anyone know if Xtandi can be had for $3 per pill or less in Canada or anywhere else?
MMK-XFuture
in
Advanced Prostate Cancer
5 years ago
Retreatment With Radium-223 in Patients With Castration-Resistant Prostate Cancer and Bone Metastases
Concomitant cytotoxic agents were not allowed during re-treatment but were allowed at the investigator's discretion during follow-up; other concomitant agents for prostate cancer (including abiraterone acetate or
enzalutamide
) were allowed at investigator's discretion.
Concomitant cytotoxic agents were not allowed during re-treatment but were allowed at the investigator's discretion during follow-up; other concomitant agents for prostate cancer (including abiraterone acetate or
enzalutamide
) were allowed at investigator's discretion.
Balsam01
in
Advanced Prostate Cancer
5 years ago
What I learned from today's conference call...
Already approved:
enzalutamide
and apalutamide. New this year: darolutamide, an androgen receptor signaling inhibitor. Very positive results are being seen, better tolerated side effects, and a good safety profile. So, how to decide what to do?
Already approved:
enzalutamide
and apalutamide. New this year: darolutamide, an androgen receptor signaling inhibitor. Very positive results are being seen, better tolerated side effects, and a good safety profile. So, how to decide what to do?
tallguy2
in
Advanced Prostate Cancer
5 years ago
Pembrolizumab in Patients With Heavily Treated Metastatic Castration-Resistant Prostate Cancer
Despite prior progression on
enzalutamide
, 48% (23/48) of men were treated with concurrent
enzalutamide
.
Despite prior progression on
enzalutamide
, 48% (23/48) of men were treated with concurrent
enzalutamide
.
Balsam01
in
Advanced Prostate Cancer
5 years ago
Denied for Vision Trial
While we were waiting for all the tests, his PSA went up to 530.62 so the doctor prescribed him Xtandi (
enzalutamide
) . It seems like he has more energy now. But I'm really scared how long it will last..... Will you please let me know what option will we have after Xtandi fail on him?
While we were waiting for all the tests, his PSA went up to 530.62 so the doctor prescribed him Xtandi (
enzalutamide
) . It seems like he has more energy now. But I'm really scared how long it will last..... Will you please let me know what option will we have after Xtandi fail on him?
Muzpapa
in
Advanced Prostate Cancer
5 years ago
Radium-223 in Clinical Practice. Video
The PEACE III trial [[i]A Randomized Multicenter Phase III Trial Comparing
Enzalutamide
vs. a Combination of Ra223 and
Enzalutamide
in Asymptomatic or Mildly Symptomatic Castration Resistant Prostate Cancer Patients Metastatic to Bone[/i]] is mentioned.
The PEACE III trial [[i]A Randomized Multicenter Phase III Trial Comparing
Enzalutamide
vs. a Combination of Ra223 and
Enzalutamide
in Asymptomatic or Mildly Symptomatic Castration Resistant Prostate Cancer Patients Metastatic to Bone[/i]] is mentioned.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Enzalutamide working for my dad
We basically came to the conclusion for him to go on
Enzalutamide
since he has HTN and severe white coat syndrome! 3 weeks on
Enzalutamide
PSA dropped like a stone to 1.8!
We basically came to the conclusion for him to go on
Enzalutamide
since he has HTN and severe white coat syndrome! 3 weeks on
Enzalutamide
PSA dropped like a stone to 1.8!
fmoser
in
Advanced Prostate Cancer
5 years ago
Enzalutamide and docetaxel together?
Just wondering if anyone out there has done these two treatments together? And if so, what were the side effects and did you have any favorable results? Thanks much!!
Just wondering if anyone out there has done these two treatments together? And if so, what were the side effects and did you have any favorable results? Thanks much!!
MeliaQuinn
in
Advanced Prostate Cancer
5 years ago
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