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BRCA, ATM, CHEK news: ASCO GU 2021: Talazoparib Demonstrates Durable Antitumor Activity in Metastatic Castration-Resistant Prostate Cancer
The patients had previously received one to two taxane-based chemotherapy regimens and at least one hormonal therapy with
enzalutamide
and/or abiraterone acetate given in the metastatic setting.
The patients had previously received one to two taxane-based chemotherapy regimens and at least one hormonal therapy with
enzalutamide
and/or abiraterone acetate given in the metastatic setting.
Balsam01
in
Advanced Prostate Cancer
3 years ago
Does anyone have any thoughts on an alternative to radiation to the spine (2nd time around)?
Currently I’m on Eligard and
Enzalutamide
. The thought is that the BAT treatment may have made the PC cells sensitive to these two drugs again. I do not and never believed PC would kill me, so I'm concerned with my longterm outlook. Thank you in advance for taking the time to read. :-)
Currently I’m on Eligard and
Enzalutamide
. The thought is that the BAT treatment may have made the PC cells sensitive to these two drugs again. I do not and never believed PC would kill me, so I'm concerned with my longterm outlook. Thank you in advance for taking the time to read. :-)
skateguy
in
Advanced Prostate Cancer
3 years ago
Prostate Cancer
I had a second option at UCLA Medical Center, and they suggested I do Apalutamide or
Enzalutamide
. I would like to hear from anyone who has had these other drugs and results... I am with Kaiser and wonder ??
I had a second option at UCLA Medical Center, and they suggested I do Apalutamide or
Enzalutamide
. I would like to hear from anyone who has had these other drugs and results... I am with Kaiser and wonder ??
pdaleuski
in
Advanced Prostate Cancer
3 years ago
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Enter trial of Opvido (Nivolumab) or Placebo in Combination With Docetaxel in men With Advanced Castration-resistant Prostate Cancer- Hurry
Abiraterone,
enzalutamide
, apalitamide, darolutamide, etc) in the metastatic setting (can have received up to 2 hormonal therapies in the non-metastatic setting) You must live in either the USA or Canada.
Abiraterone,
enzalutamide
, apalitamide, darolutamide, etc) in the metastatic setting (can have received up to 2 hormonal therapies in the non-metastatic setting) You must live in either the USA or Canada.
Darryl
Partner
in
Advanced Prostate Cancer
3 years ago
Casodex/Bicalutamide or MDV3100/Enzalutamide can lead to promotion rather than suppression of Prostate Cancer Metastasis
Just came across this study that seems like quite an important finding for those of us who might be taking or have taken Casodex/Bicalutamide or
enzalutamide
.
Just came across this study that seems like quite an important finding for those of us who might be taking or have taken Casodex/Bicalutamide or
enzalutamide
.
Mascouche
in
Advanced Prostate Cancer
3 years ago
Bipolar androgen therapy [BAT] sensitizes CRPC to subsequent ADT
"After progression on BAT, 17 of 18 patients ... achieved a PSA50 response and 15 of 18 patients ... achieved a PSA90 response on abiraterone or
enzalutamide
. "Twelve of 15 patients ... with metastatic CRPC remain on abiraterone or
enzalutamide
with a median duration of follow-up of 11.2 months."
"After progression on BAT, 17 of 18 patients ... achieved a PSA50 response and 15 of 18 patients ... achieved a PSA90 response on abiraterone or
enzalutamide
. "Twelve of 15 patients ... with metastatic CRPC remain on abiraterone or
enzalutamide
with a median duration of follow-up of 11.2 months."
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Claim your spot in Immunotherapy Trial testing Opvido for prostate cancer. Hurry, please
Abiraterone,
enzalutamide
, apalitamide, darolutamide, etc) in the metastatic setting (can have received up to 2 hormonal therapies in the non-metastatic setting) You must live in either the USA or Canada.
Abiraterone,
enzalutamide
, apalitamide, darolutamide, etc) in the metastatic setting (can have received up to 2 hormonal therapies in the non-metastatic setting) You must live in either the USA or Canada.
Darryl
Partner
in
Advanced Prostate Cancer
3 years ago
Sequencing Opportunity?
https://www.urotoday.com/conference-highlights/asco-2020/asco-2020-prostate-cancer/121890-asco-2020-transformer-bipolar-androgen-therapy-vs-
enzalutamide
-for-castration-resistant-metastatic-prostate-cancer.html
https://www.urotoday.com/conference-highlights/asco-2020/asco-2020-prostate-cancer/121890-asco-2020-transformer-bipolar-androgen-therapy-vs-
enzalutamide
-for-castration-resistant-metastatic-prostate-cancer.html
taylor123
in
Advanced Prostate Cancer
3 years ago
Radiotherapy on Prostate. Recommendations?
on my dad who was diagnosed in Feb last year; T3b, N1 (left external iliac, bilateral common iliac, para aortic and bilateral hilar lymph nodes) M1b L5 metastases, Gleason 4+4 adenocarcinoma of prostate Presenting PSA: 97 He was initially placed on zoladex injections and was also placed on
Enzalutamide
on my dad who was diagnosed in Feb last year; T3b, N1 (left external iliac, bilateral common iliac, para aortic and bilateral hilar lymph nodes) M1b L5 metastases, Gleason 4+4 adenocarcinoma of prostate Presenting PSA: 97 He was initially placed on zoladex injections and was also placed on
Enzalutamide
Hillwalker87
in
Advanced Prostate Cancer
3 years ago
What if your loved one could get access to free immunotherapy treatment using Nivolumab, also known as OPDIVO?
Abiraterone,
enzalutamide
, apalitamide, darolutamide, etc) in the metastatic setting (can have received up to 2 hormonal therapies in the non-metastatic setting) You must live in either the USA or Canada Start your inquiry even if you are not sure that you qualify: malecare.org/clinical-trial
Abiraterone,
enzalutamide
, apalitamide, darolutamide, etc) in the metastatic setting (can have received up to 2 hormonal therapies in the non-metastatic setting) You must live in either the USA or Canada Start your inquiry even if you are not sure that you qualify: malecare.org/clinical-trial
Darryl
Partner
in
Prostate Cancer Caregivers
3 years ago
What if you could get access to free immunotherapy treatment using Nivolumab, also known as OPDIVO?
Abiraterone,
enzalutamide
, apalitamide, darolutamide, etc) in the metastatic setting (can have received up to 2 hormonal therapies in the non-metastatic setting) You must live in either the USA or Canada Start your inquiry even if you are not sure that you qualify: malecare.org/clinical-trial
Abiraterone,
enzalutamide
, apalitamide, darolutamide, etc) in the metastatic setting (can have received up to 2 hormonal therapies in the non-metastatic setting) You must live in either the USA or Canada Start your inquiry even if you are not sure that you qualify: malecare.org/clinical-trial
Darryl
Partner
in
Prostate Cancer And Gay Men
3 years ago
Exclusive Fasttrak - Apply to clinical trial testing a new immunotherapy for prostate cancer!
Abiraterone,
enzalutamide
, apalitamide, darolutamide, etc) in the metastatic setting (can have received up to 2 hormonal therapies in the non-metastatic setting) You must live in either the USA or Canada Start your inquiry even if you are not sure that you qualify: https://malecare.org/clinical-trial
Abiraterone,
enzalutamide
, apalitamide, darolutamide, etc) in the metastatic setting (can have received up to 2 hormonal therapies in the non-metastatic setting) You must live in either the USA or Canada Start your inquiry even if you are not sure that you qualify: https://malecare.org/clinical-trial
Darryl
Partner
in
Advanced Prostate Cancer
3 years ago
General Advice from You Brain boxes 😉
background info on my dad who was diagnosed in Feb last year; T3b, N1 (left external iliac, bilateral common iliac, para aortic and bilateral hilar lymph nodes) M1b L5 metastases, Gleason 4+4 adenocarcinoma of prostate Presenting PSA: 97 He was initially placed on zoladex injections and was also placed on
Enzalutamide
background info on my dad who was diagnosed in Feb last year; T3b, N1 (left external iliac, bilateral common iliac, para aortic and bilateral hilar lymph nodes) M1b L5 metastases, Gleason 4+4 adenocarcinoma of prostate Presenting PSA: 97 He was initially placed on zoladex injections and was also placed on
Enzalutamide
Hillwalker87
in
Advanced Prostate Cancer
3 years ago
Target PSA value?
I got spinal compressive surgery Aug. 1 and was started on lupron +
enzalutamide
(Xtandi). Since then my PSA and been falling and this week is down to 0.3 ng/mL. I am also doing a lot of alternative medicine as a companion and want to go off hormone blockers and cycle if needed once i hit nadir.
I got spinal compressive surgery Aug. 1 and was started on lupron +
enzalutamide
(Xtandi). Since then my PSA and been falling and this week is down to 0.3 ng/mL. I am also doing a lot of alternative medicine as a companion and want to go off hormone blockers and cycle if needed once i hit nadir.
Biteson62
in
Advanced Prostate Cancer
3 years ago
Planned Chemo tomorrow need suggestion and information
As PSA(200) started increasing doctor asked to go on
Enzalutamide
, initially for 1 month it worked, and thereafter PSA started increasing. for the past 3 months, we were on
Enzalutamide
. Now PSA is 517. Doctor asked to go for Chemo I have attached his prescription.
As PSA(200) started increasing doctor asked to go on
Enzalutamide
, initially for 1 month it worked, and thereafter PSA started increasing. for the past 3 months, we were on
Enzalutamide
. Now PSA is 517. Doctor asked to go for Chemo I have attached his prescription.
Vasanta
in
Advanced Prostate Cancer
3 years ago
EMBARK trial results already available?
EMBARK is a randomized Phase 3 study of
enzalutamide
plus leuprolide,
enzalutamide
monotherapy, and leuprolide alone in men with high-risk non-metastatic HSPC.
EMBARK is a randomized Phase 3 study of
enzalutamide
plus leuprolide,
enzalutamide
monotherapy, and leuprolide alone in men with high-risk non-metastatic HSPC.
GP24
in
Advanced Prostate Cancer
3 years ago
BAT: transformer trial
(Testosterone Revival Abolishes Negative Symptoms, Fosters Objective Response and Modulates
Enzalutamide
Resistance (Transformer) – what violence we do to language in science!) In this one they took about 200 asymptomatic patients who had progressed on abiraterone and had not taken
enzalutamide
.
(Testosterone Revival Abolishes Negative Symptoms, Fosters Objective Response and Modulates
Enzalutamide
Resistance (Transformer) – what violence we do to language in science!) In this one they took about 200 asymptomatic patients who had progressed on abiraterone and had not taken
enzalutamide
.
kaptank
in
Advanced Prostate Cancer
3 years ago
Neuroendocrine cells.
GnRH agonists and antagonists), inhibiting intratumoral androgen synthesis (i.e. abiraterone acetate) or competitive inhibition of AR itself (i.e.
enzalutamide
). This treatment, although initially effective, eventually fails after the tumor cells develop various mechanisms of resistance.
GnRH agonists and antagonists), inhibiting intratumoral androgen synthesis (i.e. abiraterone acetate) or competitive inhibition of AR itself (i.e.
enzalutamide
). This treatment, although initially effective, eventually fails after the tumor cells develop various mechanisms of resistance.
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Advice and Opinions would be great.
*
Enzalutamide
(Xtandi) * Ketoconazole * High dose Testosterone to shock the PCa cells.
*
Enzalutamide
(Xtandi) * Ketoconazole * High dose Testosterone to shock the PCa cells.
taylor123
in
Advanced Prostate Cancer
3 years ago
Update to Can't treat what we can't see
Following is from the After Visit Summary: We discussed a recommendation for
enzalutamide
at this point - while it may have a lower response rate compared to docetaxel, especially after progression on abiraterone therapy, the toxicity of docetaxel is significantly greater, especially in the context
Following is from the After Visit Summary: We discussed a recommendation for
enzalutamide
at this point - while it may have a lower response rate compared to docetaxel, especially after progression on abiraterone therapy, the toxicity of docetaxel is significantly greater, especially in the context
SF22
in
Advanced Prostate Cancer
3 years ago
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