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Advice needed please.
We are scheduled to see Dr Nick Plowman on Harley Street (He was strongly recommended by Dr Khoo at the Royal Marsden) My Father has never had radiation, chemo, xandti, enzalutamide,
denosumab
etc. What other treatments are viable at this stage?
We are scheduled to see Dr Nick Plowman on Harley Street (He was strongly recommended by Dr Khoo at the Royal Marsden) My Father has never had radiation, chemo, xandti, enzalutamide,
denosumab
etc. What other treatments are viable at this stage?
taylor123
in
Advanced Prostate Cancer
5 years ago
stopping denosumab (Prolia)
https://www.researchgate.net/publication/330483705_Stopping_Denosumab
https://www.researchgate.net/publication/330483705_Stopping_Denosumab
HeronNS
in
Osteoporosis Support
5 years ago
Osteoporosis treatment
Is the effects of Prolia (
denosumab
) leave the body quickly and generally disappear after one stops taking them? I was told that alendronate, Zolendronic acid stay in the bones after you stop taking them and will continue to work and offer protection even afer one stops taking them. Is it true?
Is the effects of Prolia (
denosumab
) leave the body quickly and generally disappear after one stops taking them? I was told that alendronate, Zolendronic acid stay in the bones after you stop taking them and will continue to work and offer protection even afer one stops taking them. Is it true?
smtamt
in
Osteoporosis Support
5 years ago
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1 day Fasting
I've been thinking about when would be the best time to do it in conjunction with my meds - Ibrance and Letrozole at the moment, about to start
Denosumab
soon (Xgeva I think it's called in America).
I've been thinking about when would be the best time to do it in conjunction with my meds - Ibrance and Letrozole at the moment, about to start
Denosumab
soon (Xgeva I think it's called in America).
Mindysooty
in
SHARE Metastatic Breast Cancer
5 years ago
which is the better treatment for osteoporosis for post menopausal woman of 78 years?
Which is the best treatment for post menopausal woman of 78 years : a) Prolia (
denosumab
injection) or b) Aclasta (zolendronic acid) ? smtkrgsl (son)
Which is the best treatment for post menopausal woman of 78 years : a) Prolia (
denosumab
injection) or b) Aclasta (zolendronic acid) ? smtkrgsl (son)
smtamt
in
Osteoporosis Support
5 years ago
Approved Treatments for Triple Negative MBC Patients
Patients with bone metastases should receive a bone-directed therapy such as Xgeva (
Denosumab
) or Zometa (Zoledronic acid) in addition to their other therapy.
Patients with bone metastases should receive a bone-directed therapy such as Xgeva (
Denosumab
) or Zometa (Zoledronic acid) in addition to their other therapy.
Bestbird
in
SHARE Metastatic Breast Cancer
5 years ago
FDA-Approved Treatments for HER2+, Hormone Receptor Negative Patients
Patients with bone metastases should receive a bone-directed therapy such as Xgeva (
Denosumab
) or Zometa (Zoledronic acid) in addition to their other therapy.
Patients with bone metastases should receive a bone-directed therapy such as Xgeva (
Denosumab
) or Zometa (Zoledronic acid) in addition to their other therapy.
Bestbird
in
SHARE Metastatic Breast Cancer
5 years ago
Approved Therapies for Triple Positive (HR+, HER2+) MBC Patients
Patients with bone metastases should receive a bone-directed therapy such as Xgeva (
Denosumab
) or Zometa (Zoledronic acid) in addition to their other therapy.
Patients with bone metastases should receive a bone-directed therapy such as Xgeva (
Denosumab
) or Zometa (Zoledronic acid) in addition to their other therapy.
Bestbird
in
SHARE Metastatic Breast Cancer
5 years ago
A Detailed History of my PMR Journey
My doctor also prescribed an injection of Prolia (
denosumab
) every six months to avoid osteoporosis. Along the way, I developed Achilles tendinitis from an injury while exercising. I was taking 10 mg prednisone at the time and I presume the prednisone weakened my tendon.
My doctor also prescribed an injection of Prolia (
denosumab
) every six months to avoid osteoporosis. Along the way, I developed Achilles tendinitis from an injury while exercising. I was taking 10 mg prednisone at the time and I presume the prednisone weakened my tendon.
Doclew44
in
PMRGCAuk
5 years ago
FDA-Approved Treatments for HR+, HER2- Premenopausal Patients
If you have bone metastases, you should receive a bone-directed therapy such as Xgeva (
Denosumab
) or Zometa (Zoledronic acid) in addition to your other therapy.
If you have bone metastases, you should receive a bone-directed therapy such as Xgeva (
Denosumab
) or Zometa (Zoledronic acid) in addition to your other therapy.
Bestbird
in
SHARE Metastatic Breast Cancer
5 years ago
Approved Treatment Options for HR+, HER2- Postmenopausal Women
Patients with bone metastases should receive a bone-directed therapy such as Xgeva (
Denosumab
) or Zometa (Zoledronic acid) in addition to their other therapy.
Patients with bone metastases should receive a bone-directed therapy such as Xgeva (
Denosumab
) or Zometa (Zoledronic acid) in addition to their other therapy.
Bestbird
in
SHARE Metastatic Breast Cancer
5 years ago
Prolia advert
And then in the end, how she was still living her life - and the words Prolia
denosumab
on the screen. Makes me sick, but the company must be getting worried if they are flogging it on tv now. This is how they get unwitting patients to ask their doctor for a prescription.
And then in the end, how she was still living her life - and the words Prolia
denosumab
on the screen. Makes me sick, but the company must be getting worried if they are flogging it on tv now. This is how they get unwitting patients to ask their doctor for a prescription.
HeronNS
in
Bone Health and Osteoporosis UK
5 years ago
Inhibition of NFκB Reduces Prostate Cancer Related Osteoclastogenesis In Vitro and Osteolysis Ex Vivo.
{Note that
Denosumab
[Xgeva] is also a RANKL inhibitor.}
{Note that
Denosumab
[Xgeva] is also a RANKL inhibitor.}
pjoshea13
in
Advanced Prostate Cancer
5 years ago
I'm new here - Denosumab?
The
Denosumab
in particular seems like a risk too far at the moment having read about people with serious long term bad effects, increased risk of fractures if you come off it, possible jaw problems etc etc...
The
Denosumab
in particular seems like a risk too far at the moment having read about people with serious long term bad effects, increased risk of fractures if you come off it, possible jaw problems etc etc...
LouisaMay
in
SHARE Metastatic Breast Cancer
5 years ago
Denosumab/Xgeva
I’m just about to have my first bone strengthening injection and have just read the side effects. Now I am terrified. Have to leave in 1hr. Has anyone had a bad reaction to it? Do I really need it?
I’m just about to have my first bone strengthening injection and have just read the side effects. Now I am terrified. Have to leave in 1hr. Has anyone had a bad reaction to it? Do I really need it?
Toomanyquestions
in
SHARE Metastatic Breast Cancer
5 years ago
Prednisone to Blame for ERA 223 Trial Failure?
“However, if deemed necessary by the clinicians, concomitant administration of bone resorption inhibitors (
denosumab
and bisphosphonates) are needed to counteract the increased risk of fragility skeletal fractures.”
“However, if deemed necessary by the clinicians, concomitant administration of bone resorption inhibitors (
denosumab
and bisphosphonates) are needed to counteract the increased risk of fragility skeletal fractures.”
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Question for men on Denosumab (Xgeva)
Has anyone here on
denosumab
experienced the rare side effect of atypical femoral fracture? I’ve had mets at the top of my right femur for some time, and there’s rarely been pain. This week’s bone scan shows the mets creeping downward about to the center of the femur.
Has anyone here on
denosumab
experienced the rare side effect of atypical femoral fracture? I’ve had mets at the top of my right femur for some time, and there’s rarely been pain. This week’s bone scan shows the mets creeping downward about to the center of the femur.
YostConner
in
Advanced Prostate Cancer
5 years ago
No meds can help - ANY FURTHER OPTIONS - please?
As far as I know there are only bisphosphonates,
denosumab
and parathyroid. It infuriates me that patients aren't WARNED about the "drug prison" you end up in when you take Prolia. You can never go off it, once you take it. I am very angry.
As far as I know there are only bisphosphonates,
denosumab
and parathyroid. It infuriates me that patients aren't WARNED about the "drug prison" you end up in when you take Prolia. You can never go off it, once you take it. I am very angry.
DianeBM
in
Bone Health and Osteoporosis UK
5 years ago
Bisphosphonates & Prolia -- DANGEROUS
The new line of drugs are called
Denosumab
(of which Prolia is very popular). Arguebly, the new drugs are worse because they go upstream and suppress precursor proteins such as something called RANKL or RANK ligand -- which has many functions other than just activating osteoclasts.
The new line of drugs are called
Denosumab
(of which Prolia is very popular). Arguebly, the new drugs are worse because they go upstream and suppress precursor proteins such as something called RANKL or RANK ligand -- which has many functions other than just activating osteoclasts.
SandyABC
in
Bone Health and Osteoporosis UK
5 years ago
Xgeva / calcium & vitamin D.
Severe hypocalcaemia is a rare and dangerous side effect of
denosumab
. We present a case of a patient with metastatic prostate cancer who developed severe hypocalcaemia after receiving a single dose of
denosumab
.
Severe hypocalcaemia is a rare and dangerous side effect of
denosumab
. We present a case of a patient with metastatic prostate cancer who developed severe hypocalcaemia after receiving a single dose of
denosumab
.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
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