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Androgen receptor mutations for precision medicine in prostate cancer - Endocrine-Related Cancer, Review Article, Published: 17 Aug 2022
[/i] [i]Keywords:
abiraterone
; androgen receptor; antiandrogen; mutation; steroid[/i] . . .
[/i] [i]Keywords:
abiraterone
; androgen receptor; antiandrogen; mutation; steroid[/i] . . .
cujoe
in
Fight Prostate Cancer
2 years ago
Tough Questions
He has gone through docetaxal (almost killed him), Lupron, Xtandi,
Abiraterone
, Xgeva, immunotherapy, palliative radiation, and next was going to be cabazitaxal. His labs came back with his platelets at51, too low for treatment.
He has gone through docetaxal (almost killed him), Lupron, Xtandi,
Abiraterone
, Xgeva, immunotherapy, palliative radiation, and next was going to be cabazitaxal. His labs came back with his platelets at51, too low for treatment.
Sipj
in
Advanced Prostate Cancer
2 years ago
Breaking androgen receptor addiction of prostate cancer by targeting different functional domains in the treatment of advanced disease
This is technical at first but if you work your way through it there are excellent data on why
abiraterone
, apilutamide, Enzalutimide fail, and how pretty awesome darolutamide is, but its not invincible.
This is technical at first but if you work your way through it there are excellent data on why
abiraterone
, apilutamide, Enzalutimide fail, and how pretty awesome darolutamide is, but its not invincible.
KocoPr
in
Advanced Prostate Cancer
2 years ago
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Prolactin & Abiraterone
Keywords:
abiraterone
; castration resistant; prognosis; prolactin; prostate cancer. © 2022 Wiley Periodicals LLC.
Keywords:
abiraterone
; castration resistant; prognosis; prolactin; prostate cancer. © 2022 Wiley Periodicals LLC.
pjoshea13
in
Advanced Prostate Cancer
2 years ago
Am I missing any options / pipeline developments that could allow me to stop HT?
I am on monthly Degarelix and daily
Abiraterone
. Clearly I love my PSA having the less than sign and want it to stay that way but am starting to be miserable with how much the HT is changing me. it’s not just the no libido which on its own is a QOL disaster but the energy and drive loss.
I am on monthly Degarelix and daily
Abiraterone
. Clearly I love my PSA having the less than sign and want it to stay that way but am starting to be miserable with how much the HT is changing me. it’s not just the no libido which on its own is a QOL disaster but the energy and drive loss.
Brysonal
in
Advanced Prostate Cancer
2 years ago
Got my genomic analysis - sounds like there are possibilities?
I'm high volume metastatic cancer, currently on Lupron, had to stop
abiraterone
due to liver numbers off, & had 1st Docetaxel chemo a week ago. Sounds like Keytruda could be beneficial as immunotherapy. Possibly concurrent with docetaxel? What should I get out of these results?
I'm high volume metastatic cancer, currently on Lupron, had to stop
abiraterone
due to liver numbers off, & had 1st Docetaxel chemo a week ago. Sounds like Keytruda could be beneficial as immunotherapy. Possibly concurrent with docetaxel? What should I get out of these results?
rsgdmd
in
Advanced Prostate Cancer
2 years ago
Anti-PCa effects of statins, prednisone, aspirin and denosumab (Xgeva)
I will be getting it in late December, and already get prednisone in conjunction with
abiraterone
, and am on a statin I used to need but no longer for lipid purposes. Does anyone have info about low dose aspirin with regard to anti-PCa effects?
I will be getting it in late December, and already get prednisone in conjunction with
abiraterone
, and am on a statin I used to need but no longer for lipid purposes. Does anyone have info about low dose aspirin with regard to anti-PCa effects?
Derf4223
in
Advanced Prostate Cancer
1 year ago
Where should I purchase Abiraterone from
Where is the best place to purchase
Abiraterone
from? Need to take 1000 mgs a day on an empty stomach for 1.5 to 2 yrs. Yearly cost with my Medicare part D drug plan from Wellcare is very high. Good RX looks promising but will their price last over time?
Where is the best place to purchase
Abiraterone
from? Need to take 1000 mgs a day on an empty stomach for 1.5 to 2 yrs. Yearly cost with my Medicare part D drug plan from Wellcare is very high. Good RX looks promising but will their price last over time?
snugrose
in
Advanced Prostate Cancer
2 years ago
Pluvicto increases radiographic progression-free survival (rPFS) before chemo
https://clinicaltrials.gov/ct2/show/NCT04689828 It tested whether giving Pluvicto increases radiographic progression-free survival (rPFS) in men who: (1) have failed one of the second-line hormonals (
abiraterone
, enzalutamide, darolutamide, or apalutamide) (2) have not had taxane chemo (3) are metastatic
https://clinicaltrials.gov/ct2/show/NCT04689828 It tested whether giving Pluvicto increases radiographic progression-free survival (rPFS) in men who: (1) have failed one of the second-line hormonals (
abiraterone
, enzalutamide, darolutamide, or apalutamide) (2) have not had taxane chemo (3) are metastatic
Tall_Allen
in
Advanced Prostate Cancer
1 year ago
NEXT STEP IMRT
I'm also scheduled to talk with my Uro Oncologist on 8/3/2022 about starting either enzalutamide or
abiraterone
+ prednisone. Plan is to hit it hard up front to delay BCR as long as possible. 7/27/22 - PSA 0.01. T - 11.
I'm also scheduled to talk with my Uro Oncologist on 8/3/2022 about starting either enzalutamide or
abiraterone
+ prednisone. Plan is to hit it hard up front to delay BCR as long as possible. 7/27/22 - PSA 0.01. T - 11.
GMan-62
in
Advanced Prostate Cancer
2 years ago
Pluvicto plus Xtandi
I’ve run the gambit of Bicalutamide, Docetaxel,
Abiraterone
, Cabazitaxel, still taking Lupron and Zometa. At the beginning of June I started Enzalutamide (Xtandi) 4x40 mg. After about a month I started having issues with fatigue, loss of appetite, nausea and dizziness.
I’ve run the gambit of Bicalutamide, Docetaxel,
Abiraterone
, Cabazitaxel, still taking Lupron and Zometa. At the beginning of June I started Enzalutamide (Xtandi) 4x40 mg. After about a month I started having issues with fatigue, loss of appetite, nausea and dizziness.
Rondief
in
Advanced Prostate Cancer
2 years ago
Now on ADT, what to add?
My medical oncologist is now suggesting adding either 6 cycles of chemotherapy (Doxetaxel) or
Abiraterone
. I have also been looking at adding either Enzalutamide (Xtandi), Darolutamide or even Apalutamide.
My medical oncologist is now suggesting adding either 6 cycles of chemotherapy (Doxetaxel) or
Abiraterone
. I have also been looking at adding either Enzalutamide (Xtandi), Darolutamide or even Apalutamide.
x-rays1
in
Advanced Prostate Cancer
2 years ago
A case to push for darolutamide.
And even shows resistant variants to
abiraterone
, corticosteroids, estrodiol, all the lutamides. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230763/#!
And even shows resistant variants to
abiraterone
, corticosteroids, estrodiol, all the lutamides. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8230763/#!
KocoPr
in
Advanced Prostate Cancer
2 years ago
Docetaxel didn't work, what's next?
He was commenced on
ABIRATERONE
and PREDNISONE May 25, 2021. CT CAP on December 23,2021, progression of hepatic metastatic disease and new metastatic left obturator lymph node. There are additional prominent inguinal, iliac and retroperitoneal lymph nodes.
He was commenced on
ABIRATERONE
and PREDNISONE May 25, 2021. CT CAP on December 23,2021, progression of hepatic metastatic disease and new metastatic left obturator lymph node. There are additional prominent inguinal, iliac and retroperitoneal lymph nodes.
anscombethomson
in
Advanced Prostate Cancer
2 years ago
ADT Holiday
PSA dropped from 54.5 to 2.1 after first ADT treatment 8/21 then <.064, <0.64 <.064 for the next 3 month intervals of Lupron,
Abiraterone
, prednisone. I keep reading about ADT holidays. Under what conditions is that advisable?
PSA dropped from 54.5 to 2.1 after first ADT treatment 8/21 then <.064, <0.64 <.064 for the next 3 month intervals of Lupron,
Abiraterone
, prednisone. I keep reading about ADT holidays. Under what conditions is that advisable?
alperk
in
Advanced Prostate Cancer
2 years ago
Strength Training Problem; Advice?
My only therapy for mPC DX 4 years ago has been ADT (Lupron &
abiraterone
). So far so good in that my PSA remains < 0.1 and occasional imaging indicates that my upper spine met isn’t growing. I’ve learned to live with all the usual SEs. Immediately after DX, I stepped up my exercising at the gym.
My only therapy for mPC DX 4 years ago has been ADT (Lupron &
abiraterone
). So far so good in that my PSA remains < 0.1 and occasional imaging indicates that my upper spine met isn’t growing. I’ve learned to live with all the usual SEs. Immediately after DX, I stepped up my exercising at the gym.
Gearhead
in
Advanced Prostate Cancer
1 year ago
Rising blood pressure
So - long version: I'm 8 months in on
Abiraterone
+Prednisone, 1000mg and 5mg daily. I also consume 50 mg daily of Losartan (25 mg twice a day) to help control my blood pressure. Losartan is an ARB. I finished radiation just before Thanksgiving.
So - long version: I'm 8 months in on
Abiraterone
+Prednisone, 1000mg and 5mg daily. I also consume 50 mg daily of Losartan (25 mg twice a day) to help control my blood pressure. Losartan is an ARB. I finished radiation just before Thanksgiving.
chickgreen
in
Advanced Prostate Cancer
1 year ago
Itchy Hands
Has anyone else experienced itchy hands, fingers etc while on Lupron,
Abiraterone
and prednisone? I’m an extremely clean person, it this came out of nowhere. Thanks.
Has anyone else experienced itchy hands, fingers etc while on Lupron,
Abiraterone
and prednisone? I’m an extremely clean person, it this came out of nowhere. Thanks.
JamesHughs
in
Advanced Prostate Cancer
2 years ago
My Mother’s BC
I’m on Lupron,
Abiraterone
, and prednisone to stop the spread. I received scan throughout my diagnosis stage. I just found it odd there is a rush to remove her tumor without determining if it had spread. All comments are appreciated. Thank you!
I’m on Lupron,
Abiraterone
, and prednisone to stop the spread. I received scan throughout my diagnosis stage. I just found it odd there is a rush to remove her tumor without determining if it had spread. All comments are appreciated. Thank you!
OFPF16
in
My Breast Cancer Community
2 years ago
Is there any data on abiraterone and blood pressure
I am on
Abiraterone
and have both high and variable BP
I am on
Abiraterone
and have both high and variable BP
Dlanghorne
in
Advanced Prostate Cancer
2 years ago
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