I was at the connective tissue disease clinic on Thursday in Bristol. I have mixed connective tissue disease and my raynauds is really bad. I was under a consultant in Scotland until October 2011 and she'd tried me on every drug she could think of (which never made any difference) and given me illoprost around 9 times but it never really worked well as I could never tolerate a high dose and it generally made me ill. The consultant I've seen in Bristol has been pretty good, he's put me on losartan but I haven't felt that's made much difference and he suggested trying illoprost but rather than having it for 6 hours a day for 5 days and gradually building it up they would give it at the lowest dose but for 24 hours a day for 5 days so that you get much more but shouldn't get the side effects.... I said I'd try it so they will hopefully confirm in the new year. Has anyone else tried it?