I’m on Ibrance and experienced a reaction. My onc said I can wait it out or switch to Kisquali which I heard had a longer time before it starts to fail but worse side effects?
Does anyone have any experience with both or either? Curious about kisquali!
I was on Kisqali for 22 months before progression. It was the easiest of the three medicines I have been on. I did have to reduce the dosage from the maximum because of fatigue but then it was fine. The doctor put me on Kisqali instead of Ibrance because she said there was a lessor chance for blood clots and I had a history of those. Wishing you the best. Audrey
Hi
I have a little experience with both…but I’m the reverse of you. I started on Kisqali as a first line treatment but I only managed 3 months. My liver reacted to it so after taking a month and a half off all meds to stabilise my liver enzymes I was switched to Ibrance.
My oncologist decided not to attempt a reduced dose route before switching as she thought I was obviously sensitive to Kisqali and that would waste time.
I’m into the 4th cycle of Ibrance now and all blood work is good. My WBC seems better with Ibrance and I have more energy without a slump at the end of week three.
Everyone has a slightly different reaction, so in the same way….but opposite, Kisqali might work for you.
Apart from the enzyme issue I felt ok on it. No nausea or diarrhoea….a little fogginess, but that might of been tied into my liver playing up….oh I had some rashes too all over my arms and legs…Like heat rash but it didn’t go away until I came off the meds.
Hope you find a treatment that works well for you
Love Zoe xx
Everyone is different! Kisqali is a brand new drug isn’t it?
I’m on Ibrance now and wonder if Kisqali would be a second line treatment. I’m ER+PR+HER2-
I had a reaction to Ibrance when I first began treatment 125mg. Rash all over upper chest that went away gradually over several weeks. I have been on Ibrance almost 4 years now with no sign of progression. I also had a bout with diarrhea that lasted a day or so.
What was your reaction?
Thank you ladies for your knowledge and support!
I am ER/PR+ Her- Lobular. I had full body itchy rash big patches of red, dry eyes, muscle aches. I want to hang on. My onc said that switching down the road to another med like Kisquali was not an option I would need second line therapy? I don’t think I agree with that.. I’ve heard otherwise from so many. That when one drug stops go to the next. He said no.. it would be second line.
I have lobular as well and have been doing a lot of research on the cdk inhibitors (ibrance, kisqali and verzenio). I’ve read that kisqali and verzenio are more potent cdk inhibitors than ibrance. There is currently a study comparing ibrance to verzenio head to head and the results should be out soon. Look into “treatment holidays” as well. They are finding after a certain amount of time off of a cdk inhibitor you’re body may re-respond once back on. I feel most oncologists don’t do the type of research needed for special subtypes of cancer..lobular can respond differently to different types of treatment. There are studies/trials out there just for invasive lobular. I like to bring my research to the oncologist. Take care 
Mandy
Mandy, I agree with you. I have been researching also. I know there is a Natalee study on Ribo now. I was thinking to ride out Ibrance if it’s working. Are you on Ribo/ Kisquali?
I’ve been on ibrance for almost two years and it looks like my markers may be creeping up a bit so I’m doing my research now. Came across a lot of research that may indicate ibrance is the weaker of the 3.
I’ve been on Ibrance for a year now. At the beginning I did lose a lot of hair, but that has tapered off. I do seem to get little rashes now and then, but not sure I can blame them on the Ibrance. My wbc has come back to a good level. I’m hopeful! Good luck!
Your response to Ibrance sounds like my response to 600 mg Kisqali. I started with 400 mg. Kisqali because I was concerned about side effects. I didn't react much to the 400 mg but it also didn't do as well in controlling my mets. I've only had one cycle of 600 mg Kisqali but the red, itching skin rash was pretty dramatic until the week off when it cleared up. Since my blood work looks improved, I'm about to start the second cycle tomorrow so will be interested to see whether the side effects are as extreme.
I haven’t been on ibrance but I started 600mg kisqali in January and had to take a break after two weeks because my WBC RBC and Platelets all dropped.
After 2 weeks off and a new round of bloodwork, I started up again. After two weeks on my blood counts were good enough to continue the third week.
I had a small rash or hives on parts of my hands but that cleared up with about 4 Benadryl (not all at one haha).
And I have also had some tongue issues but I didn’t write down what my oncologist called it. It’s not sore but it had some surface spots that were outlined in white and my tongue had a white coating. She prescribed a ‘magic mouthwash’ concoction that seemed to work in the first few days of taking it but now doesn’t seem as effective. 🤷♀️ I’ll learn more when I see her next week.
I won’t know how it’s working on the inside until I have my next CT scan in April but I’m happy with the way it’s going so far and I’m hopeful for the scan results 🙏🤞🏻🙂
All the best with your decision
Kim
What is your experience with Verzenio as I was.just changed from Ibrance?
any experiences to share?
best treatment after Xeloda?
Ibrance and your hair
Side effects of iBrance vs Kisqali
