Brain Imaging Identifies Heightened Motor Excitability in Restless Legs Syndrome

[MrCrow]

Link: sleepwakeadvisor.com/news/r...

A few excerpts:

Mounting evidence has suggested that multiple cortical and subcortical regions may be involved in the pathophysiology of RLS.

Collectively, studies indicate a hyperfunctioning of excitatory mechanisms coupled with a hypo function of inhibitory controls, ultimately resulting in heightened motor excitability,” the investigators concluded. “Pathophysiologically, alterations in the somatosensory system may serve as the ‘primum movens,’ leading to widespread dysfunctional connectivity, where abnormal processing of afferent inputs triggers unnecessary motor behaviors.

The investigators noted that many of the included studies did not account for a history of dopaminergic medication or other drugs affecting outcomes.

[MrCrow]

Maybe it’s not always about Muh Dopamine and Muh brain iron but there several possible ways by which one can have these symptoms. There’s another research investigating the role of endorphins and natural opioids in CSF as well. Multiple causes should necessitate multiple different solutions.

[Madlegs1]

Sounds like the TV set up in the hospital I'm in!🤕